Interações de Isotretinoína

Isotretinoína (Accutane, Absorica, Claravis), retinoide, tem 44 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 8; moderadas: 7; leves: 29; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (8)

  • AcitretinaretinoideGrave

    Acitretin is contraindicated in cases of hypersensitivity (e.g., angioedema, urticaria) to the preparation (acitretin or excipients) or to other retinoids . (bula de Acitretina, Contraindicações)

  • Demeclociclinaantibiótico da classe das tetraciclinasGrave

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • Doxiciclinaantibiótico da classe das tetraciclinasGrave

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • Minociclinaantibiótico da classe das tetraciclinasGrave

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • Tetraciclinaantibiótico da classe das tetraciclinasGrave

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • Tigeciclinaantibiótico da classe das tetraciclinasGrave

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (bula de Isotretinoína, Advertências e precauções)

  • TretinoínaretinoideGrave

    Tretinoin capsules are contraindicated in patients with a known hypersensitivity to tretinoin capsules, any of its components, or other retinoids. (bula de Tretinoína, Contraindicações)

Interações moderadas (7)

  • ÁlcoolÁlcoolModerada

    Some patients have been able to reverse triglyceride elevation by reduction in weight and restriction of dietary fat and alcohol while continuing isotretinoin or through dosage reduction. (bula de Isotretinoína, Advertências e precauções)

  • Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (bula de Cloreto de cálcio, Interações medicamentosas)

  • Patients with elevated vitamin A levels may be at increased risk. (bula de Elexacaftor + tezacaftor + ivacaftor, Advertências e precauções)

  • Ivacaftorinibidor da CYP3A4Moderada

    Patients with elevated vitamin A levels may be at increased risk. (bula de Ivacaftor, Advertências e precauções)

  • LomitapidaModerada

    Caution should be exercised when JUXTAPID is used with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen. (bula de Lomitapida, Advertências e precauções)

  • MetotrexatoimunossupressorModerada

    Monitor patients receiving XATMEP with other potential hepatotoxins (e.g., azathioprine, retinoids, and sulfasalazine) for possible signs of hepatotoxicity. (bula de Metotrexato, Interações medicamentosas)

  • OrlistateModerada

    The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (bula de Orlistate, Interações medicamentosas)

Menções leves (29)

  • Although the overall incidence of tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. (bula de Isotretinoína, Advertências e precauções)

  • Ácido acetilsalicílico + dipiridamolantiagregante plaquetárioLeve

    Although the overall incidence of tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. (bula de Isotretinoína, Advertências e precauções)

  • Although the overall incidence of tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. (bula de Isotretinoína, Advertências e precauções)

  • Although the overall incidence of tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. (bula de Isotretinoína, Advertências e precauções)

  • Desogestrel + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Drospirenona + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • EstradiolestrogênioLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Estradiol + dienogesteanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Fluconazolantifúngico azólicoLeve

    Vitamin A Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of fluconazole treatment. (bula de Fluconazol, Interações medicamentosas)

  • FulvestrantoestrogênioLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (bula de Gliconato de cálcio, Interações medicamentosas)

  • LevonorgestrelprogestinaLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Levonorgestrel + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • MedroxiprogesteronaprogestinaLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • MegestrolprogestinaLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Mifepristonainibidor da CYP3A4Leve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • NoretisteronaprogestinaLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Noretisterona + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Norgestimato + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Norgestrel + etinilestradiolanticoncepcional oralLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

  • Although the overall incidence of tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. (bula de Isotretinoína, Advertências e precauções)

  • ProgesteronaprogestinaLeve

    Oral Contraceptives Isotretinoin Capsules did not result in clinically significant changes in the pharmacokinetics of norethindrone and ethinyl estradiol when used concomitantly with a norethindrone and ethinyl estradiol oral contraceptive [see Clinical Pharmacology ( 12.3 )]. (bula de Isotretinoína, Interações medicamentosas)

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.