Interações de Rasagilina

Rasagilina (Azilect), inibidor da MAO, tem 224 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 117; moderadas: 98; leves: 9; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (117)

  • Amitriptilinaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Amoxapinaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Anfepramona (dietilpropiona)estimulante do SNCGrave

    During or within 14 days following the administration of monoamine oxidase inhibitors, hypertensive crises may result. (bula de Anfepramona (dietilpropiona), Contraindicações)

  • Anfetaminaestimulante do SNCGrave

    Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [ see Warnings and Precautions (5.7) , Drug Interactions (7.1) ]. (bula de Anfetamina, Contraindicações)

  • Anfetamina + dextroanfetaminaestimulante do SNCGrave

    Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [see Adverse Reactions ( 6.2 )] . taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive… (bula de Anfetamina + dextroanfetamina, Contraindicações)

  • Apraclonidinaagonista alfa-adrenérgicoGrave

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (bula de Apraclonidina, Contraindicações)

  • Atomoxetinainibidor da recaptação de noradrenalinaGrave

    Taking, or within 14 days of stopping, a monoamine oxidase inhibitor (MAOI) [see Drug Interactions (7) ] . (bula de Atomoxetina, Contraindicações)

  • Azul de metilenoinibidor da MAOGrave

    John’s wort, cyclobenzaprine, or another (selective or non-selective) MAO inhibitor ( 4 ) (bula de Rasagilina, Contraindicações)

  • Beladona + ópioopioideGrave

    …Precautions (5.2) ] • Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [ see Warnings and Precautions (5.5) ] • Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [ see Warnings and Precautions (5.7), Drug Interactions (7) ] • Known or suspected gastrointestinal obstruction,… (bula de Beladona + ópio, Contraindicações)

  • Benzfetaminaestimulante do SNCGrave

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (bula de Benzfetamina, Contraindicações)

  • Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior. (bula de Rasagilina, Contraindicações)

  • BuprenorfinaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions (5.2) ]. (bula de Buprenorfina, Interações medicamentosas)

  • Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma). (bula de Buprenorfina + naloxona, Interações medicamentosas)

  • BupropionaantidepressivoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Buspironamedicamento serotoninérgicoGrave

    The use of monoamine oxidase inhibitors (MAOIs) intended to treat depression with buspirone or within 14 days of stopping treatment with buspirone is contraindicated because of an increased risk of serotonin syndrome and/or elevated blood pressure. (bula de Buspirona, Contraindicações)

  • …respiratory depression [see Warnings and Precautions ( 5.9 ) ] Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment[see Warnings and Precautions ( 5.9 ) ] Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions ( 5.10 ) / Drug Interactions ( 7 ) ]. (bula de Butalbital + ácido acetilsalicílico + cafeína + codeína, Contraindicações)

  • …Precautions ( 5.2 )] • Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see Warnings and Precautions ( 5.10 )] • Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions ( 5.11 ), Drug Interactions ( 7 )] • Known or suspected gastrointestinal obstruction,… (bula de Butalbital + paracetamol + cafeína + codeína, Contraindicações)

  • ButorfanolopioideGrave

    …medical attention if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see WARNINGS ; ADVERSE REACTIONS ].‎ Serotonin Syndrome Inform patients that butorphanol tartrate could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Butorfanol, Precauções)

  • CarbamazepinaanticonvulsivanteGrave

    Concomitant use of monoamine oxidase inhibitors (MAOIs). (bula de Carbamazepina, Contraindicações)

  • Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with levodopa or carbidopa-levodopa combination products with or without carbidopa. (bula de Carbidopa, Contraindicações)

  • Carbidopa + levodopamedicamento dopaminérgicoGrave

    DUOPA is contraindicated in patients who are currently taking a nonselective monoamine oxidase (MAO) inhibitor (e.g., phenelzine and tranylcypromine) or have recently (within 2 weeks) taken a nonselective MAO inhibitor. (bula de Carbidopa + levodopa, Contraindicações)

  • Carbidopa + levodopa + entacaponamedicamento dopaminérgicoGrave

    Carbidopa, levodopa and entacapone tablets is contraindicated in patients: Taking nonselective monoamine oxidase (MAO) inhibitors (e.g., phenelzine and tranylcypromine). (bula de Carbidopa + levodopa + entacapona, Contraindicações)

  • Carbinoxaminaanti-histamínicoGrave

    …because deaths have been reported in this age group [see Warnings and Precautions (5.1)]. patients who are hypersensitive to carbinoxamine maleate or any of the inactive ingredients in Carbinoxamine Maleate Extended-Release Oral Suspension [see Warnings and Precautions (5.4)]. patients who are taking monoamine oxidase inhibitors (MAOI) [see Drug Interactions (7)]. (bula de Carbinoxamina, Contraindicações)

  • Ciclobenzaprinarelaxante muscularGrave

    John’s wort and with cyclobenzaprine. (bula de Rasagilina, Contraindicações)

  • Ciproeptadinaanti-histamínicoGrave

    Monoamine oxidase inhibitor therapy (See DRUG INTERACTIONS ). (bula de Ciproeptadina, Contraindicações)

  • CitalopramISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Clomipraminaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • CodeínaopioideGrave

    • Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions ( 5.10 ), Drug Interactions ( 7 )]. (bula de Codeína, Contraindicações)

  • Desipraminaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Deutetrabenazinainibidor do VMAT2Grave

    Taking monoamine oxidase inhibitors (MAOIs). (bula de Deutetrabenazina, Contraindicações)

  • Dexclorfeniraminaanti-histamínicoGrave

    Antihistamines are also contraindicated in the following conditions: Hypersensitivity to dexchlorpheniramine maleate or other antihistamines of similar chemical structure Monoamine oxidase inhibitor therapy (See Drug Interaction section) (bula de Dexclorfeniramina, Contraindicações)

  • Dexmetilfenidatoestimulante do SNCGrave

    • Concomitant treatment with monoamine oxidase inhibitors (MAOIs) or within 14 days following discontinuation of treatment with an MAOI, because of the risk of hypertensive crises [see Drug Interactions ( 7.1 )] . (bula de Dexmetilfenidato, Contraindicações)

  • Dextroanfetaminaestimulante do SNCGrave

    Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Warnings and Drug Interactions ]. (bula de Dextroanfetamina, Contraindicações)

  • Dextrometorfanomedicamento serotoninérgicoGrave

    Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior. (bula de Rasagilina, Contraindicações)

  • Dextrometorfano + quinidinamedicamento serotoninérgicoGrave

    Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior. (bula de Rasagilina, Contraindicações)

  • Avoid use of diphenoxylate hydrochloride and atropine sulfate in patients who take MAOIs and monitor for signs and symptoms of hypertensive crisis (headache, hyperthermia, hypertension). (bula de Difenoxilato + atropina, Interações medicamentosas)

  • Doxepinaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Doxilamina + piridoxinaanti-histamínicoGrave

    …Known hypersensitivity to doxylamine succinate, other ethanolamine derivative antihistamines, pyridoxine hydrochloride or any inactive ingredient in the formulation Monoamine oxidase (MAO) inhibitors intensify and prolong the adverse central nervous system effects of doxylamine succinate and pyridoxine hydrochloride delayed-release tablets [ see Drug Interactions… (bula de Doxilamina + piridoxina, Contraindicações)

  • DroxidopasimpaticomiméticoGrave

    However, based on mechanism of action, the use of non-selective MAO inhibitors and linezolid should be avoided as there is a potential for increased blood pressure when taken with NORTHERA. (bula de Droxidopa, Interações medicamentosas)

  • DuloxetinaIRSNGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • EletriptanatriptanoGrave

    Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during co-administration of triptans and SSRIs, SNRIs, TCAs and MAO inhibitors [see Warnings and Precautions (5.7) ]. (bula de Eletriptana, Interações medicamentosas)

  • Erva-de-são-joão (hipérico)Fitoterápicos e suplementosGrave

    Combinar a erva-de-são-joão (hipérico) com antidepressivos e outros medicamentos serotoninérgicos aumenta o risco de síndrome serotoninérgica. (NCCIH, St. John's Wort)

  • EscitalopramISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Fendimetrazinaestimulante do SNCGrave

    …coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension, pulmonary hypertension) • During or within 14 days following the administration of monoamine oxidase inhibitors • Hyperthyroidism • Glaucoma • Agitated states • History of drug abuse • Pregnancy (see PRECAUTIONS, Pregnancy ) • Nursing • Use in combination with other… (bula de Fendimetrazina, Contraindicações)

  • Fenelzinainibidor da MAOGrave

    John’s wort, cyclobenzaprine, or another (selective or non-selective) MAO inhibitor ( 4 ) (bula de Rasagilina, Contraindicações)

  • FentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Fentanila, Advertências e precauções)

  • Fenterminaestimulante do SNCGrave

    …cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension) • During or within 14 days following the administration of monoamine oxidase inhibitors • Hyperthyroidism • Glaucoma • Agitated states • History of drug abuse • Pregnancy [ see Use in Specific Populations () ] • Nursing [ see Use in Specific… (bula de Fentermina, Contraindicações)

  • Fentermina + topiramatoestimulante do SNCGrave

    …Warnings and Precautions (5.1) and Use in Specific Populations (8.1) ] With glaucoma [see Warnings and Precautions (5.3) ] With hyperthyroidism Taking or within 14 days of stopping a monoamine oxidase inhibitors [see Drug Interactions (7) ] With known hypersensitivity to phentermine, topiramate or any of the excipients in phentermine and topiramate extended-release… (bula de Fentermina + topiramato, Contraindicações)

  • FluoxetinaISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • FluvoxaminaISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • FrovatriptanatriptanoGrave

    Selective Serotonin Reuptake Inhibitors / Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during combined use of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [ see Warnings and Precautions (5.7) ]. (bula de Frovatriptana, Interações medicamentosas)

  • Granisetronamedicamento que prolonga o intervalo QTGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of granisetron and other serotonergic drugs. (bula de Granisetrona, Advertências e precauções)

  • HidrocodonaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions (5.3) ] . (bula de Hidrocodona, Interações medicamentosas)

  • Serotonergic drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + clorfeniramina, Interações medicamentosas)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + homatropina, Interações medicamentosas)

  • Monoamine Oxidase Inhibitors (MAOIs) MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma). (bula de Hidrocodona + ibuprofeno, Interações medicamentosas)

  • The use of hydrocodone bitartrate and acetaminophen tablets is not recommended for patients taking MAOIs or within 14 days of stopping such treatment. (bula de Hidrocodona + paracetamol, Interações medicamentosas)

  • HidromorfonaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions ( 5.3 )]. (bula de Hidromorfona, Interações medicamentosas)

  • Imipraminaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • IsoniazidaantibióticoGrave

    John’s wort, cyclobenzaprine, or another (selective or non-selective) MAO inhibitor ( 4 ) (bula de Rasagilina, Contraindicações)

  • Levodopamedicamento dopaminérgicoGrave

    INBRIJA is contraindicated in patients currently taking a nonselective monoamine oxidase (MAO) inhibitor (e.g., phenelzine and tranylcypromine) or who have recently (within 2 weeks) taken a nonselective MAO inhibitor. (bula de Levodopa, Contraindicações)

  • May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • LevorfanolopioideGrave

    Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Levorfanol, Precauções)

  • LinezolidaantibióticoGrave

    John’s wort, cyclobenzaprine, or another (selective or non-selective) MAO inhibitor ( 4 ) (bula de Rasagilina, Contraindicações)

  • Lisdexanfetaminaestimulante do SNCGrave

    Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Warnings and Precautions (5.7) and Drug Interactions (7.1) ] . (bula de Lisdexanfetamina, Contraindicações)

  • Lítiomedicamento serotoninérgicoGrave

    If concomitant use of lithium with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms. (bula de Lítio, Advertências e precauções)

  • MetadonaopioideGrave

    Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome [see Warnings and Precautions ( 5.2 )] . (bula de Rasagilina, Contraindicações)

  • Metanfetaminaestimulante do SNCGrave

    Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [see Adverse Reactions ( 6 )]. taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because… (bula de Metanfetamina, Contraindicações)

  • Metaxalonarelaxante muscularGrave

    Serotonin syndrome has resulted from concomitant use of metaxalone (within the recommended dosage range) and other serotonergic drugs [see Warnings and Precautions (5.1) ]. (bula de Metaxalona, Interações medicamentosas)

  • Metildopaanti-hipertensivoGrave

    CONTRAINDICATIONS Methyldopa is contraindicated in patients: – with active hepatic disease, such as acute hepatitis and active cirrhosis. – with liver disorders previously associated with methyldopa therapy (see WARNINGS ). – with hypersensitivity to any component of this product. – on therapy with monoamine oxidase (MAO) inhibitors. (bula de Metildopa, Contraindicações)

  • Metilfenidatoestimulante do SNCGrave

    Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (bula de Metilfenidato, Contraindicações)

  • Metoclopramidaantagonista da dopaminaGrave

    In one study in hypertensive patients, intravenously administered metoclopramide was shown to release catecholamines; hence, avoid use in patients with hypertension or in patients taking monoamine oxidase inhibitors [see Drug Interactions ( 7.1 )] . (bula de Metoclopramida, Advertências e precauções)

  • Midodrinaagonista alfa-adrenérgicoGrave

    Avoid use of MAO inhibitors or linezolid with midodrine. (bula de Midodrina, Interações medicamentosas)

  • MilnacipranaIRSNGrave

    Concomitant use of rasagiline with one of many classes of antidepressants (e.g., SSRIs, SNRIs, triazolopyridine, tricyclic or tetracyclic antidepressants) is not recommended [see Drug Interactions ( 7.5 )]. (bula de Rasagilina, Advertências e precauções)

  • MirtazapinaantidepressivoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • MorfinaopioideGrave

    • Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions ( 5.9 ) and Drug Interactions ( 7 )]. (bula de Morfina, Contraindicações)

  • NalbufinaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) MAOI (e.g., phenelzine, tranylcypromine, linezolid) interactions with opioids may manifest as serotonin syndrome [see PRECAUTIONS; Drug Interactions ] or opioid toxicity (e.g., respiratory depression, coma [see WARNINGS ]). (bula de Nalbufina, Interações medicamentosas)

  • Naltrexona + bupropionaantagonista opioideGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • NaratriptanatriptanoGrave

    Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during co-administration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)] . (bula de Naratriptana, Interações medicamentosas)

  • NefazodonaantidepressivoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Nortriptilinaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Olanzapina + fluoxetinaantipsicóticoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • OliceridinaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Oliceridina, Interações medicamentosas)

  • Ondansetronamedicamento que prolonga o intervalo QTGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of Ondansetron Injection and other serotonergic drugs. (bula de Ondansetrona, Advertências e precauções)

  • OxicodonaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions (5.3) ] . (bula de Oxicodona, Interações medicamentosas)

  • Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions ( 5.2)]. (bula de Oxicodona + paracetamol, Interações medicamentosas)

  • OximorfonaopioideGrave

    Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions (5.2) ]. (bula de Oximorfona, Interações medicamentosas)

  • Palonosetronamedicamento serotoninérgicoGrave

    Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of POSFREA and other serotonergic drugs. (bula de Palonosetrona, Advertências e precauções)

  • …respiratory depression ( see WARNINGS ). acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment ( see WARNINGS ). concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days ( see WARNINGS ). known or suspected gastrointestinal obstruction, including paralytic ileus ( see WARNINGS… (bula de Paracetamol + codeína, Contraindicações)

  • ParoxetinaISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Pentazocina + naloxona, Precauções)

  • Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome [see Warnings and Precautions ( 5.2 )] . (bula de Rasagilina, Contraindicações)

  • Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within 14 days [ see Warnings and Precautions (5.16) , Drug Interactions (7.6) ]. (bula de Prometazina + codeína, Contraindicações)

  • Prometazina + dextrometorfanoanti-histamínicoGrave

    Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior. (bula de Rasagilina, Contraindicações)

  • Protriptilinaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • PseudoefedrinadescongestionanteGrave

    Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (bula de Pseudoefedrina, Advertências)

  • RemifentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Remifentanila, Advertências e precauções)

  • RizatriptanatriptanoGrave

    Monoamine Oxidase Inhibitors MAXALT is contraindicated in patients taking MAO-A inhibitors and non-selective MAO inhibitors. (bula de Rizatriptana, Interações medicamentosas)

  • Selegilinainibidor da MAOGrave

    …concomitant use of an antidepressant (e.g., selective serotonin reuptake inhibitors-SSRIs, serotonin-norepinephrine reuptake inhibitors-SNRIs, tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants) and a nonselective MAOI (e.g., phenelzine, tranylcypromine) or selective MAO-B inhibitors, such as selegiline (Eldepryl) and rasagiline . (bula de Rasagilina, Advertências e precauções)

  • SertralinaISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Solriamfetolestimulante do SNCGrave

    Concomitant use of rasagiline with one of many classes of antidepressants (e.g., SSRIs, SNRIs, triazolopyridine, tricyclic or tetracyclic antidepressants) is not recommended [see Drug Interactions ( 7.5 )]. (bula de Rasagilina, Advertências e precauções)

  • SumatriptanatriptanoGrave

    Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)] . (bula de Sumatriptana, Interações medicamentosas)

  • Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Clinical Impact: Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.11)] . (bula de Sumatriptana + naproxeno, Interações medicamentosas)

  • TapentadolopioideGrave

    …suspected paralytic ileus [see Warnings and Precautions (5.12) ] Hypersensitivity to tapentadol (e.g., anaphylaxis, angioedema) or to any other ingredients of the product [see Adverse Reactions (6.2) ] Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Drug Interactions (7) ] Significant respiratory depression ( 4 ) (bula de Tapentadol, Contraindicações)

  • Tetrabenazinainibidor do VMAT2Grave

    • Taking monoamine oxidase inhibitors (MAOIs). (bula de Tetrabenazina, Contraindicações)

  • TramadolopioideGrave

    Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome [see Warnings and Precautions ( 5.2 )] . (bula de Rasagilina, Contraindicações)

  • Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome [see Warnings and Precautions ( 5.2 )] . (bula de Rasagilina, Contraindicações)

  • Tranilciprominainibidor da MAOGrave

    …concomitant use of an antidepressant (e.g., selective serotonin reuptake inhibitors-SSRIs, serotonin-norepinephrine reuptake inhibitors-SNRIs, tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants) and a nonselective MAOI (e.g., phenelzine, tranylcypromine) or selective MAO-B inhibitors, such as selegiline (Eldepryl) and rasagiline . (bula de Rasagilina, Advertências e precauções)

  • TrazodonaantidepressivoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Trimipraminaantidepressivo tricíclicoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Valbenazinainibidor do VMAT2Grave

    Dose adjustments due to drug interactions ( 2.4 , 7.1 ): Factors Dose Adjustments for INGREZZA and INGREZZA SPRINKLE Use of MAOIs with INGREZZA or INGREZZA SPRINKLE Avoid concomitant use with MAOIs. (bula de Valbenazina, Interações medicamentosas)

  • VenlafaxinaIRSNGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • VilazodonaISRSGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • Viloxazinainibidor da recaptação de noradrenalinaGrave

    Qelbree is contraindicated in patients: receiving concomitant treatment with monoamine oxidase inhibitors (MAOI), or within 14 days following discontinuing an MAOI, because of an increased risk of hypertensive crisis [see Drug Interactions (7.1) ] . receiving concomitant administration of sensitive CYP1A2 substrates or CYP1A2 substrates with a narrow therapeutic… (bula de Viloxazina, Contraindicações)

  • VortioxetinaantidepressivoGrave

    May cause serotonin syndrome when used with antidepressants ( 5.2 ) (bula de Rasagilina, Advertências e precauções)

  • ZiprasidonaantipsicóticoGrave

    • Concomitant use of monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs. (bula de Ziprasidona, Contraindicações)

Interações moderadas (98)

  • AmantadinaanticolinérgicoModerada

    Decreasing the levodopa dose may lessen or eliminate this side effect ( 5.7 ) (bula de Rasagilina, Advertências e precauções)

  • Arformoterolagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • AripiprazolantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Armodafinilaestimulante do SNCModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Articaína + epinefrinaanestésico localModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • AsenapinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • BrexpiprazolantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Brimonidinaagonista alfa-adrenérgicoModerada

    Monoamine oxidase inhibitors may result in increased hypotension. (bula de Brimonidina, Interações medicamentosas)

  • Brimonidina + timololagonista alfa-adrenérgicoModerada

    Monoamine oxidase inhibitors may result in increased hypotension. (bula de Brimonidina + timolol, Interações medicamentosas)

  • Bromocriptinaagonista da dopaminaModerada

    For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication. (bula de Rasagilina, Advertências e precauções)

  • Budesonida + formoterolcorticosteroideModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Bupivacaínaanestésico localModerada

    …of Adverse Reactions Due to Drug Interactions with MARCAINE WITH EPINEPHRINE Risk of Severe, Persistent Hypertension Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving monoamine oxidase inhibitors… (bula de Bupivacaína, Advertências e precauções)

  • Bupivacaína + epinefrinaanestésico localModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Butalbital + paracetamolbarbitúricoModerada

    Drug Interactions The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors. (bula de Butalbital + paracetamol, Interações medicamentosas)

  • Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Cabergolinaagonista da dopaminaModerada

    For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication. (bula de Rasagilina, Advertências e precauções)

  • Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. (bula de Rasagilina, Advertências e precauções)

  • CariprazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • CarvedilolbetabloqueadorModerada

    Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (bula de Carvedilol, Interações medicamentosas)

  • Cimetidinabloqueador H2Moderada

    Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. (bula de Rasagilina, Advertências e precauções)

  • CiprofloxacinofluoroquinolonaModerada

    …with rasagiline, patients should be advised of the potential to develop drowsiness and specifically asked about factors that may increase the risk with rasagiline such as concomitant sedating medications, the presence of sleep disorders, and concomitant medications that increase rasagiline plasma levels (e.g., ciprofloxacin) [see Drug Interactions ( 7.6 )] . (bula de Rasagilina, Advertências e precauções)

  • Clemastinaanti-histamínicoModerada

    Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of antihistamines. (bula de Clemastina, Interações medicamentosas)

  • ClonazepambenzodiazepínicoModerada

    …Interactions The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. (bula de Clonazepam, Interações medicamentosas)

  • ClorazepatobenzodiazepínicoModerada

    The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants. (bula de Clorazepato, Interações medicamentosas)

  • Cloroprocaínaanestésico localModerada

    Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. (bula de Cloroprocaína, Precauções)

  • ClorpromazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • ClozapinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Cocaínaanestésico localModerada

    Monoamine-oxidase inhibitors: Concomitant administration may potentiate the effects and toxicity of monoamine-oxidase inhibitors. (bula de Cocaína, Interações medicamentosas)

  • Deferasiroxsuplemento de ferroModerada

    Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. (bula de Rasagilina, Advertências e precauções)

  • DiazepambenzodiazepínicoModerada

    …be given to the pharmacology of the agents employed particularly with compounds that may potentiate or be potentiated by the action of Valium, such as phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, sedative antihistamines, narcotics, barbiturates, MAO inhibitors and other antidepressants. (bula de Diazepam, Interações medicamentosas)

  • DicicloverinaanticolinérgicoModerada

    …drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (bula de Dicicloverina, Interações medicamentosas)

  • Difenidraminaanti-histamínicoModerada

    MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. (bula de Difenidramina, Interações medicamentosas)

  • DobutaminasimpaticomiméticoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Droperidolantagonista da dopaminaModerada

    …1) clinically significant bradycardia (less than 50 bpm), 2) any clinically significant cardiac disease, 3) treatment with Class I and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval (see PRECAUTIONS, Drug Interactions ), and 6) electrolyte imbalance,… (bula de Droperidol, Advertências)

  • EfedrinasimpaticomiméticoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Epinefrina (adrenalina)simpaticomiméticoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Ergotamina + cafeínaalcaloide do ergotModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • EstazolambenzodiazepínicoModerada

    The action of the benzodiazepines may be potentiated by anticonvulsants, antihistamines, alcohol, barbiturates, monoamine oxidase inhibitors, narcotics, phenothiazines, psychotropic medications, or other drugs that produce CNS depression. (bula de Estazolam, Interações medicamentosas)

  • FenilefrinadescongestionanteModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • FlufenazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Fluticasona + salmeterolcorticosteroideModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Formoterolagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • GlibenclamidasulfonilureiaModerada

    …Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (bula de Glibenclamida, Interações medicamentosas)

  • GlimepiridasulfonilureiaModerada

    …steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. (bula de Glimepirida, Interações medicamentosas)

  • GlipizidasulfonilureiaModerada

    …increase the susceptibility to and/or intensity of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, nonsteroidal anti-inflammatory… (bula de Glipizida, Interações medicamentosas)

  • Glipizida + metforminasulfonilureiaModerada

    Glipizide: The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents. (bula de Glipizida + metformina, Precauções)

  • HaloperidolantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • HidralazinavasodilatadorModerada

    Drug Interactions MAO inhibitors should be used with caution in patients receiving hydralazine. (bula de Hidralazina, Interações medicamentosas)

  • IloperidonaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Insulina asparteinsulinaModerada

    Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. (bula de Insulina asparte, Interações medicamentosas)

  • Insulina degludecainsulinaModerada

    …Degludec Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (bula de Insulina degludeca, Interações medicamentosas)

  • Insulina detemirinsulinaModerada

    …with LEVEMIR Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (bula de Insulina detemir, Interações medicamentosas)

  • Insulina glarginainsulinaModerada

    …Glargine-yfgn Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (bula de Insulina glargina, Interações medicamentosas)

  • Insulina lisproinsulinaModerada

    Clinically Significant Drug Interactions with LYUMJEV Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (bula de Insulina lispro, Interações medicamentosas)

  • …Significant Drug Interactions with AFREZZA Antidiabetic agents, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blocking Agents, Disopyramide, Fibrates, Fluoxetine, Monoamine Oxidase Inhibitors, Pentoxifylline, Pramlintide, Salicylates, Somatostatin Analogs (e.g., octreotide), and Sulfonamide Antibiotics Prevention or Management Monitor blood glucose… (bula de Insulina regular (humana), Interações medicamentosas)

  • Ipratrópio + salbutamolanticolinérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Isofluranoanestésico geralModerada

    Concomitant Use with MAO Inhibitors Concomitant use of MAO inhibitors and inhalational anesthetics may increase the risk of hemodynamic instability during surgery or medical procedures. (bula de Isoflurano, Interações medicamentosas)

  • Isoprenalina (isoproterenol)agonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Levossalbutamolagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Lidocaínaanestésico localModerada

    Clinically Significant Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. (bula de Lidocaína, Interações medicamentosas)

  • Lidocaína + epinefrinaanestésico localModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • LoxapinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • LumateperonaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • LurasidonaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Mepivacaínaanestésico localModerada

    Likewise, solutions of mepivacaine containing a vasoconstrictor, such as epinephrine, should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types, because severe prolonged hypertension may result. (bula de Mepivacaína, Advertências)

  • MetoprololbetabloqueadorModerada

    Catecholamine depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) may have an additive effect when given with beta-blocking agents. (bula de Metoprolol, Interações medicamentosas)

  • Metoprolol + hidroclorotiazidabetabloqueadorModerada

    Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

  • MexiletinaantiarrítmicoModerada

    Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. (bula de Rasagilina, Advertências e precauções)

  • Mirabegronaagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Modafinilaestimulante do SNCModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • NateglinidameglitinidaModerada

    …Nateglinide Drugs That May Increase the Blood-Glucose-Lowering Effect of Nateglinide and Susceptibility to Hypoglycemia Drugs: Nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents, anabolic hormones (e.g., methandrostenolone), guanethidine, gymnema sylvestre, glucomannan, thioctic acid,… (bula de Nateglinida, Interações medicamentosas)

  • OlanzapinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • OximetazolinadescongestionanteModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • PaliperidonaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • PerfenazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • PimavanserinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • PimozidaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Pioglitazona + glimepiridatiazolidinedionaModerada

    …steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. (bula de Pioglitazona + glimepirida, Interações medicamentosas)

  • Pramipexolagonista da dopaminaModerada

    For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication. (bula de Rasagilina, Advertências e precauções)

  • Prilocaína + epinefrinaanestésico localModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • ProclorperazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Prometazinaanti-histamínicoModerada

    Monoamine Oxidase Inhibitors (MAOI) Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. (bula de Prometazina, Interações medicamentosas)

  • QuetiapinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • RisperidonaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Ropinirolagonista da dopaminaModerada

    For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication. (bula de Rasagilina, Advertências e precauções)

  • Salbutamolagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Salmeterolagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Sevofluranoanestésico geralModerada

    Non-selective MAO-inhibitors Concomitant use of MAO inhibitors and inhalational anesthetics may increase the risk of hemodynamic instability during surgery or medical procedures. (bula de Sevoflurano, Interações medicamentosas)

  • Suxametônio (succinilcolina)bloqueador neuromuscularModerada

    The neuromuscular blocking effect of succinylcholine may be enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives, glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma cholinesterase [see Warnings and Precautions (5.9) ]. (bula de Suxametônio (succinilcolina), Interações medicamentosas)

  • Terbutalinaagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • TioridazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • TiotixenoantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • TrifluoperazinaantipsicóticoModerada

    Withdrawal-Emergent Hyperpyrexia and Confusion A symptom complex resembling neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in drugs that increase central… (bula de Rasagilina, Advertências e precauções)

  • Umeclidínio + vilanterolanticolinérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Vibegronaagonista beta-adrenérgicoModerada

    Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications. (bula de Rasagilina, Interações medicamentosas)

  • Zileutonainibidor da CYP1A2Moderada

    Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. (bula de Rasagilina, Advertências e precauções)

Menções leves (9)

  • Drug Interactions Since the chemical structure of difenoxin hydrochloride is similar to meperidine hydrochloride, the concurrent use of MOTOFEN ® with monoamine oxidase inhibitors may, in theory, precipitate a hypertensive crisis. (bula de Difenoxina + atropina, Interações medicamentosas)

  • It is theoretically possible, therefore, that the combination of Entacapone Tablets and a non-selective MAO inhibitor (e.g., phenelzine and tranylcypromine) would result in inhibition of the majority of the pathways responsible for normal catecholamine metabolism. (bula de Entacapona, Advertências)

  • Examples: Nonsteroidal anti-inflammatory agents and other highly protein-boind drugs, salicylcates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, beta-adrenergic blocking agents; potentially with ciprofloxacin, micronazole. (bula de Glibenclamida + metformina, Interações medicamentosas)

  • PropranololbetabloqueadorLeve

    Antidepressants: The hypotensive effect of MAO inhibitors or tricyclic antidepressants may be exacerbated when administered with beta-blockers. (bula de Propranolol, Interações medicamentosas)

  • RepaglinidameglitinidaLeve

    Examples: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, nonsteroidal anti-inflammatory agents (NSAIDs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (bula de Repaglinida, Interações medicamentosas)

  • TerbinafinaantifúngicoLeve

    Drugs predominantly metabolized by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Type B. (bula de Terbinafina, Interações medicamentosas)

  • It is theoretically possible, therefore, that the combination of Tolcapone tablets and a non-selective MAO inhibitor (e.g., phenelzine and tranylcypromine) would result in inhibition of the majority of the pathways responsible for normal catecholamine metabolism. (bula de Tolcapona, Advertências)

  • TriexifenidilanticolinérgicoLeve

    Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. (bula de Triexifenidil, Interações medicamentosas)

  • ZolmitriptanatriptanoLeve

    Serotonin Syndrome Serotonin syndrome may occur with triptans, including zolmitriptan, particularly during co-administration with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and MAO inhibitors [see Drug Interactions ( 7.5 )] . (bula de Zolmitriptana, Advertências e precauções)

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.