Interações de Vincristina

Vincristina (Vincasar PFS) tem 97 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 51; moderadas: 31; leves: 15; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (51)

  • Abrocitinibeinibidor da JAKGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • AmiodaronaantiarrítmicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Aprepitantoinibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • AtazanavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • CenobamatoanticonvulsivanteGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Cetoconazolantifúngico azólicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • CiclosporinaimunossupressorGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Cimetidinabloqueador H2Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Claritromicinaantibiótico macrolídeoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • DarunavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Darunavir + cobicistateantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Diltiazembloqueador dos canais de cálcioGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • DronedaronaantiarrítmicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • EfavirenzantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Eritromicinaantibiótico macrolídeoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • EtravirinaantirretroviralGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • EverolimoimunossupressorGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Flibanserinadepressor do SNCGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Fluconazolantifúngico azólicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • FosamprenavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Fosaprepitantoinibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. (bula de Vincristina, Advertência em caixa preta)

  • Imatinibeinibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • IsoniazidaantibióticoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Itraconazolantifúngico azólicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Ivacaftorinibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Lapatinibeinibidor da glicoproteína PGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • LenacapavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Lopinavir + ritonavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Mifepristonainibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Mirabegronaagonista beta-adrenérgicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Mitapivateindutor da CYP3A4Grave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • NefazodonaantidepressivoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Nilotinibemedicamento que prolonga o intervalo QTGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Palbociclibeinibidor da CYP3A4Grave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • PerampanelanticonvulsivanteGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Posaconazolantifúngico azólicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • PropafenonaantiarrítmicoGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • QuinidinaantiarrítmicoGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Ranolazinamedicamento que prolonga o intervalo QTGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • RitonavirantirretroviralGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Suvorexantosedativo-hipnóticoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Ticagrelorantiagregante plaquetárioGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Verapamilbloqueador dos canais de cálcioGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • Voriconazolantifúngico azólicoGrave

    Therefore, the concomitant use of strong CYP3A inhibitors with vincristine sulfate should be avoided. (bula de Vincristina, Interações medicamentosas)

  • ZonisamidaanticonvulsivanteGrave

    Therefore, the concomitant use of P-gp inhibitors or inducers should be avoided. (bula de Vincristina, Interações medicamentosas)

Interações moderadas (31)

  • Ácido valproicoanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • BrivaracetamanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • CarbamazepinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • CitarabinaantimetabólitoModerada

    Drug Interactions Reversible decreases in steady-state plasma digoxin concentrations and renal glycoside excretion were observed in patients receiving beta-acetyldigoxin and chemotherapy regimens containing cyclophosphamide, vincristine and prednisone with or without cytarabine injection or procarbazine. (bula de Citarabina, Interações medicamentosas)

  • ClobazambenzodiazepínicoModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • ClonazepambenzodiazepínicoModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • Divalproato de sódio (valproato)anticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • …treated with 6-mercaptopurine (500 mg/m 2 intravenously daily for 5 days per cycle every 2–3 weeks) and doxorubicin hydrochloride (50 mg/m 2 intravenous once per cycle every 2–3 weeks) alone or with vincristine and prednisone, all developed hepatic dysfunction manifested by increased total serum bilirubin, alkaline phosphatase and aspartate aminotransferase. (bula de Doxorrubicina, Interações medicamentosas)

  • EslicarbazepinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • EtossuximidaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • FelbamatoanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • FenitoínaanticonvulsivanteModerada

    The interaction may result from reduced absorption of phenytoin and an increase in the rate of its metabolism and elimination. (bula de Vincristina, Interações medicamentosas)

  • FenobarbitalbarbitúricoModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • Fentermina + topiramatoestimulante do SNCModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • FosfenitoínaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • GabapentinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • GanciclovirantiviralModerada

    …drugs associated with myelosuppression or nephrotoxicity (e.g., dapsone, doxorubicin, flucytosine, hydroxyurea, pentamidine, tacrolimus, trimethoprim/ sulfamethoxazole, vinblastine, vincristine and zidovudine) Unknown Because of potential for higher toxicity, coadministration with Ganciclovir should be considered only if the potential benefits are judged to outweigh… (bula de Ganciclovir, Interações medicamentosas)

  • LacosamidaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • LamotriginaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • LevetiracetamanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • Mesuximida (metossuximida)anticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • OxcarbazepinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • PregabalinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • PrimidonaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • RufinamidaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • TiagabinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • TopiramatoanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

  • ValganciclovirantiviralModerada

    …associated with myelosuppression or nephrotoxicity (e.g., adriamycin, dapsone, doxorubicin, flucytosine, hydroxyurea, pentamidine, tacrolimus, trimethoprim/ sulfamethoxazole, vinblastine, vincristine, and zidovudine) Unknown Because of potential for higher toxicity, coadministration with valganciclovir hydrochloride should be considered only if the potential benefits… (bula de Valganciclovir, Interações medicamentosas)

  • VasopressinaModerada

    Drugs Suspected of Causing SIADH Use with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasostrict ® . (bula de Vasopressina, Interações medicamentosas)

  • VigabatrinaanticonvulsivanteModerada

    Drug Interactions The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. (bula de Vincristina, Interações medicamentosas)

Menções leves (15)

  • Armodafinilaestimulante do SNCLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • …baseline for one patient In the combination study of bortezomib with rituximab, cyclophosphamide, doxorubicin and prednisone (BR-CAP) in previously untreated mantle cell lymphoma patients, the incidence of thrombocytopenia (≥ Grade 4) was 32% vs 1% for the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) arm as shown in Table 12 . (bula de Bortezomibe, Advertências e precauções)

  • Bosentanaindutor da CYP3A4Leve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Deferasiroxsuplemento de ferroLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • DexametasonacorticosteroideLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • GriseofulvinaantifúngicoLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Lorlatinibeindutor da CYP3A4Leve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Mitotanoindutor da CYP3A4Leve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Modafinilaestimulante do SNCLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Nafcilinaantibiótico da classe das penicilinasLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • NevirapinaantirretroviralLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • RifabutinaantibióticoLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • RifampicinaantibióticoLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • RifapentinaantibióticoLeve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

  • Suzetriginaindutor da CYP3A4Leve

    Concurrent use of strong CYP3A inducers (e.g., St. (bula de Vincristina, Interações medicamentosas)

Verifique Vincristina com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

Abrir no verificador

Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.