Interaction Checker

Calcium interactions

Calcium binds to several drugs in the gut and blocks their absorption; separating doses by a few hours usually solves it.

Calcium has 32 documented interactions across the FDA labels and fact sheets we index: 4 major, 16 moderate, 11 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This vitamin and mineral page is a starting point, not a verdict for your situation.

Major interactions (4)

  • Calcitriolvitamin D analogMajor

    Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Calcitriol label, Drug interactions)

  • NeomycinaminoglycosideMajor

    If blockage occurs, calcium salts may reverse these phenomena but mechanical respiratory assistance may be necessary. (Neomycin label, Boxed warning)

  • PhenytoinanticonvulsantMajor

    Calcium carbonate, aluminum hydroxide, magnesium hydroxide Prevention or Management: Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents (usually in combination) Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other… (Phenytoin label, Drug interactions)

  • RisedronatebisphosphonateMajor

    Calcium supplements, antacids, magnesium-based supplements or laxatives, and iron preparations interfere with the absorption of Risedronate sodium delayed-release and should not be taken together. (Risedronate label, Drug interactions)

Moderate interactions (16)

  • AlendronatebisphosphonateModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Bictegravir, emtricitabine, and tenofovir alafenamideantiretroviralModerate

    Calcium supplements can reduce absorption of these medicines; take them several hours apart. (NIH Office of Dietary Supplements, Calcium)

  • CiprofloxacinfluoroquinoloneModerate

    …polymeric phosphate binders (for example, sevelamer, lanthanum carbonate); sucralfate; Videx ® (didanosine) chewable/buffered tablets or pediatric powder; other highly buffered drugs; or products containing calcium, iron, or zinc and dairy products) Ciprofloxacin should be taken at least two hours before or six hours after Multivalent cation-containing products administration… (Ciprofloxacin label, Drug interactions)

  • DolutegravirantiretroviralModerate

    Calcium supplements can reduce absorption of these medicines; take them several hours apart. (NIH Office of Dietary Supplements, Calcium)

  • Doxycyclinetetracycline antibioticModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • IbandronatebisphosphonateModerate

    Instruct patients to take supplemental calcium and vitamin D if their dietary intake is inadequate (see Dosage and Administration [2.3] ) . (Ibandronate label, Warnings and precautions)

  • LevofloxacinfluoroquinoloneModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Levothyroxinethyroid hormoneModerate

    Calcium supplements can reduce absorption of these medicines; take them several hours apart. (NIH Office of Dietary Supplements, Calcium)

  • Liothyroninethyroid hormoneModerate

    Calcium supplements can reduce absorption of these medicines; take them several hours apart. (NIH Office of Dietary Supplements, Calcium)

  • Lithiumserotonergic drugModerate

    Calcium supplements can reduce absorption of these medicines; take them several hours apart. (NIH Office of Dietary Supplements, Calcium)

  • Minocyclinetetracycline antibioticModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • MoxifloxacinfluoroquinoloneModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • OfloxacinfluoroquinoloneModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Phentermine and topiramateCNS stimulantModerate

    Increased ratio of urinary calcium/citrate increases the risk of kidney stones and/or nephrocalcinosis. (Phentermine and topiramate label, Warnings and precautions)

  • Tetracyclinetetracycline antibioticModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • TopiramateanticonvulsantModerate

    This increased ratio of urinary calcium/citrate increases the risk of kidney stones and/or nephrocalcinosis. (Topiramate label, Warnings and precautions)

Minor mentions (11)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Chlorthalidonethiazide diureticMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • GentamicinaminoglycosideMinor

    If neuromuscular blockade occurs, calcium salts may reverse it. (Gentamicin label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Indapamidethiazide diureticMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Lisinopril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Metolazonethiazide diureticMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMinor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics reduce calcium excretion, so high calcium intake can raise blood calcium. (NIH Office of Dietary Supplements, Calcium)

No significant interaction reported (1)

  • OseltamivirantiviralNo interaction

    …Clinically Significant Drug Interaction with TAMIFLU No dose adjustments are needed for either oseltamivir or the concomitant drug when coadministering oseltamivir with amoxicillin, acetaminophen, aspirin, cimetidine, antacids (magnesium and aluminum hydroxides and calcium carbonates), rimantadine, amantadine, or warfarin [see Clinical Pharmacology (12.3) ] . (Oseltamivir label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.