تداخلات تيرزيباتيد

To avoid medication errors between LEVEMIR and other insulins, instruct patients to always check the insulin label before each injection. (نشرة إنسولين ديتيمير، التحذيرات والاحتياطات)

To avoid medication errors between LYUMJEV and other insulins, instruct patients to always check the insulin label before each injection. (نشرة إنسولين ليسبرو، التحذيرات والاحتياطات)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (نشرة بروتامين، تحذير مؤطر)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

Diabetic ketoacidosis should be treated with insulin [see Warnings and Precautions (5.1) and Warnings and Precautions (5.2) ] . (نشرة داباغليفلوزين وميتفورمين، موانع الاستعمال)

Diabetic ketoacidosis should be treated with insulin. (نشرة ساكساغليبتين وميتفورمين، موانع الاستعمال)

Antidiabetic agents Hypoglycemia including fatal outcomes have been reported. (نشرة سيبروفلوكساسين، التداخلات الدوائية)

These conditions should be treated with insulin. (نشرة غليبنكلاميد، موانع الاستعمال)

Diabetic ketoacidosis should be treated with insulin. (نشرة غليبيزيد وميتفورمين، موانع الاستعمال)

Oral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined fluconazole and glyburide use. (نشرة فلوكونازول، التداخلات الدوائية)

Hypoglycemia Chloroquine has been shown to cause severe hypoglycemia including loss of consciousness that could be life-threatening in patients treated with or without antidiabetic medications (see PRECAUTIONS , Drug Interactions ). (نشرة كلوروكين، التحذيرات)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

WARNING: RISK OF THYROID C-CELL TUMORS In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. (نشرة تيرزيباتيد، تحذير مؤطر)

Hypoglycemia PLAQUENIL can cause severe and potentially life-threatening hypoglycemia, in the presence or absence of antidiabetic agents [see Drug Interactions (7) ]. (نشرة هيدروكسي كلوروكين، التحذيرات والاحتياطات)

Monitor blood glucose in patients with diabetes and assess if antidiabetic agent dose modifications are required. (نشرة أبيراتيرون، التحذيرات والاحتياطات)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (نشرة أتازانافير، التحذيرات والاحتياطات)

At recommended doses atenolol does not potentiate insulin-induced hypoglycemia and, unlike nonselective beta- blockers, does not delay recovery of blood glucose to normal levels. (نشرة أتينولول وكلورثاليدون، التحذيرات)

Antidiabetic drugs: Dosage adjustment of antidiabetic may be required. (نشرة إربيسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

Oral Hypoglycemics Moderate doses of aspirin may increase the effectiveness of oral hypoglycemic drugs, leading to hypoglycemia. (نشرة أسبرين وديبيريدامول، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Diabetes and Hypoglycemia β-blockers may potentiate insulin-induced hypoglycemia and mask some of its manifestations such as tachycardia; however, dizziness and sweating are usually not significantly affected. (نشرة أسيبوتولول، التحذيرات)

Consideration should be taken in patients being treated with antidiabetic agents. (نشرة أسيتازولاميد، التداخلات الدوائية)

Glyburide: In a trial of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose-lowering effect of glyburide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects. (نشرة أسيتريتين، التداخلات الدوائية)

When such drugs are withdrawn from patients receiving acarbose tablets in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. (نشرة أكاربوز، التداخلات الدوائية)

• Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin: Patients taking an insulin secretagogue or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. (نشرة إكسيناتيد، التحذيرات والاحتياطات)

The effects of increases in the concentration of the progestational component norgestimate are not fully known and can include increased risk of insulin resistance, dyslipidemia, acne, and venous thrombosis. (نشرة إلفيتيغرافير وكوبيسيستات وإمتريسيتابين وتينوفوفير، التداخلات الدوائية)

الكحول قد يسبب انخفاض سكر الدم مع الإنسولين أو السلفونيل يوريا، والشرب بكثرة مع ميتفورمين يرفع خطر الحماض اللبني. (NIAAA, Harmful Interactions: Mixing Alcohol with Medicines)

Hypoglycemia: Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating Alogliptin tablets. (نشرة ألوغليبتين، التحذيرات والاحتياطات)

Hypoglycemia: Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating Alogliptin and metformin HCl tablets. (نشرة ألوغليبتين وميتفورمين، التحذيرات والاحتياطات)

Hypoglycemia: Adult patients taking an insulin secretagogue or insulin may have an increased risk of hypoglycemia. (نشرة إمباغليفلوزين، التحذيرات والاحتياطات)

Hypoglycemia: Adult patients taking an insulin secretagogue or insulin may have an increased risk of hypoglycemia. (نشرة إمباغليفلوزين وميتفورمين، التحذيرات والاحتياطات)

Antidiabetic Agents: In rare cases, diabetic patients receiving an ACE inhibitor (including benazepril) concomitantly with insulin or oral antidiabetics may develop hypoglycemia. (نشرة أملوديبين وبينازيبريل، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Increase frequency of glucose monitoring with changes to: insulin dosage, concomitantly administered glucose lowering medications, meal pattern, physical activity; and in patients with renal or hepatic impairments and hypoglycemia unawareness ( 5. (نشرة إنسولين أسبارت، التحذيرات والاحتياطات)

The risk of hypoglycemia after an injection is related to the duration of action of the insulin [see Clinical Pharmacology ( 12.2 )] and, in general, is highest when the glucose lowering effect of the insulin is maximal. (نشرة إنسولين ديغلوديك، التحذيرات والاحتياطات)

For patients with type 2 diabetes mellitus, oral antidiabetic treatment dosage modifications may be needed. (نشرة إنسولين عادي (بشري)، التحذيرات والاحتياطات)

For patients with type 2 diabetes, dosage adjustments of concomitant oral and antidiabetic products may be needed. (نشرة إنسولين غلارجين، التحذيرات والاحتياطات)

A reduction in dose of oral hypoglycemic medication (e.g., sulfonylureas) or insulin may be required in some patients [see Clinical Studies (14) ] . (نشرة أورليستات، التحذيرات والاحتياطات)

Fluoroquinolones have been associated with disturbances of blood glucose, including symptomatic hyperglycemia and hypoglycemia, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin. (نشرة أوفلوكساسين، التحذيرات)

Hypoglycemia or Hyperglycemia: Monitor glucose and adjust antidiabetic treatment as needed (‎ 5.2 ). (نشرة أوكتريوتيد، التحذيرات والاحتياطات)

• Increased amlodipine exposure when coadministered with CYP3A inhibitors Hydrochlorothiazide ( 7.3 ): • Antidiabetic drugs: Dosage adjustment of antidiabetic may be required. (نشرة أولميسارتان وأملوديبين وهيدروكلوروثيازيد، التداخلات الدوائية)

• Antidiabetic drugs: Dosage adjustment may be required. (نشرة أولميسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

Antidiabetic Drugs Repaglinide Saxagliptin Monitor for adverse reactions. (نشرة إيتراكونازول، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Antidiabetic Agents: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (نشرة بريدنيزولون، التداخلات الدوائية)

Antidiabetic agents: May increase blood glucose concentrations. (نشرة بريدنيزون، التداخلات الدوائية)

Monitor patients for the development of edema when co-administering LYRICA CR and thiazolidinedione antidiabetic agents. (نشرة بريغابالين، التحذيرات والاحتياطات)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (نشرة بريمونيدين وتيمولول، التحذيرات والاحتياطات)

Oral antidiabetic agents and insulin, causing hypoglycemia by contributing an additive effect, if dosage of Butalbital, Aspirin, and Caffeine Capsules exceeds maximum recommended daily dosage. (نشرة بوتالبيتال وأسبرين وكافيين، التداخلات الدوائية)

Evaluate the blood pressure and renal function of patients Examples: Metoprolol, propranolol Hypoglycemic Agents Clinical Impact: Aspirin may increase the serum glucose-lowering action of insulin and sulfonylureas leading to hypoglycemia. (نشرة بوتالبيتال وأسبرين وكافيين وكودايين، التداخلات الدوائية)

Unlike nonselective beta-blockers, betaxolol does not prolong insulin-induced hypoglycemia. (نشرة بيتاكسولول، التحذيرات)

Nonselective beta-blockers may potentiate insulin-induced hypoglycemia and delay recovery of serum glucose levels. (نشرة بيسوبرولول، التحذيرات)

Also, latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose. (نشرة بيسوبرولول وهيدروكلوروثيازيد، التحذيرات)

Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (نشرة بيكساروتين، التحذيرات والاحتياطات)

Hypoglycemia: Consider a lower dose of insulin or insulin secretagogue to reduce risk of hypoglycemia when used in combination with bexagliflozin tablets. (نشرة بيكساغليفلوزين، التحذيرات والاحتياطات)

Antidiabetics: Increased risk of hypoglycemia ( 7.2 ) (نشرة بينازيبريل، التداخلات الدوائية)

Antidiabetic agents: Dosage adjustment of antidiabetic drug may be required. (نشرة بينازيبريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Beta-blockade also reduces the release of insulin in response to hyperglycemia; therefore, it may be necessary to adjust the dose of antidiabetic drugs. (نشرة بيندولول، التحذيرات)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (نشرة بيوغليتازون، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (نشرة بيوغليتازون وميتفورمين، التحذيرات والاحتياطات)

(See PRECAUTIONS . ) Antidiabetic Agents Concomitant use of ACE inhibitors and antidiabetic medicines (insulin or oral hypoglycemic agents) may cause an increased blood glucose lowering effect with greater risk of hypoglycemia. (نشرة تراندولابريل، التداخلات الدوائية)

Hypoglycemia in Diabetic Patients Some MAOIs have contributed to hypoglycemic episodes in diabetic patients receiving insulin or other blood-glucose-lowering agents. (نشرة ترانيلسيبرومين، التحذيرات والاحتياطات)

Infusion of glucose and insulin has also been used to treat hyperkalemia. (نشرة تريامتيرين، التحذيرات والاحتياطات)

Oral Hypoglycemic Drugs Concurrent use with chlorpropamide may increase the risk of severe hyponatremia. (نشرة تريامتيرين وهيدروكلوروثيازيد، التداخلات الدوائية)

Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (نشرة تريامسينولون، التداخلات الدوائية)

Insulin: In patients with diabetes, concomitant use with TLANDO may decrease blood glucose and insulin requirements ( 7.1) . (نشرة تستوستيرون، التداخلات الدوائية)

Antidiabetic drugs: Dosage adjustment may be required ( 7.6 ) (نشرة تيلميسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

This may result in the need for an increase in the dose of, or initiation of, insulin and/or oral hypoglycemic agent therapy. (نشرة تيمسيروليموس، التحذيرات والاحتياطات)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (نشرة تيمولول، التحذيرات والاحتياطات)

• Hypoglycemia: Consider a lower dose of insulin or the insulin secretagogue to reduce the risk of hypoglycemia when used in combination with DAPAGLIFLOZIN TABLETS. (نشرة داباغليفلوزين، التحذيرات والاحتياطات)

Initiation or dose adjustments of insulin or oral hypoglycemic agents may be required. (نشرة دارونافير، التحذيرات والاحتياطات)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (نشرة دارونافير وكوبيسيستات، التحذيرات والاحتياطات)

Caution should be exercised when used with antidiabetic drugs. (نشرة دانازول، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (نشرة دورزولاميد وتيمولول، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with an insulin secretagogue or insulin may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة دولاغلوتيد، التحذيرات والاحتياطات)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Hyperglycemia Corticosteroids can increase blood glucose, worsen pre-existing diabetes, and predispose those on long-term therapy to diabetes mellitus, and may reduce the effect of the antidiabetic drugs. (نشرة ديكساميثازون، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (نشرة ريتونافير، التحذيرات والاحتياطات)

…Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics Sulfonylureas (e.g., glyburide, glipizide) Hormonal Contraceptives/Progestins Ethinyl estradiol, levonorgestrel Immunosuppressants Cyclosporine, tacrolimus Methylxanthines… (نشرة ريفابنتين، التداخلات الدوائية)

Decrease exposure Digitoxin Decrease exposure Fluoroquinolones Pefloxacin Administered with rifampin 900 mg daily Decrease exposure Moxifloxacin , Decrease exposure Oral Hypoglycemic Agents (e.g., sulfonylureas) Glyburide Decrease exposure Rifampin may worsen glucose control of glyburide. (نشرة ريفامبيسين، التداخلات الدوائية)

• Hypoglycemia with Concomitant Use of Insulin or Insulin Secretagogues: Consider a lower dosage of insulin or insulin secretagogue when used in combination wtih Saxagliptin tablets ( 5.3 ) (نشرة ساكساغليبتين، التحذيرات والاحتياطات)

Salicylates may enhance the hypoglycemic effect of oral antidiabetic drugs of the sulfonylurea class. (نشرة سالسالات، التداخلات الدوائية)

Antidiabetic drugs (e.g., oral agents, insulin): Dosage adjustment of the antidiabetic drug may be required (see Precautions ). (نشرة سبيرونولاكتون وهيدروكلوروثيازيد، التداخلات الدوائية)

Like other sulfonamide-containing drugs, sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics. (نشرة سلفاميثوكسازول وتريميثوبريم، التداخلات الدوائية)

Insulin and Oral Antidiabetics Hyperglycemia may occur, and the dosage of insulin or antidiabetic drugs may require adjustment. (نشرة سوتالول، التداخلات الدوائية)

Glucose Intolerance and Diabetes Mellitus: HUMATROPE may decrease insulin sensitivity, particularly at higher doses. (نشرة سوماتروبين، التحذيرات والاحتياطات)

• Hypoglycemia : Check blood glucose levels regularly and assess if antidiabetic drug dose modifications are required. (نشرة سونيتينيب، التحذيرات والاحتياطات)

Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues: Increased risk of hypoglycemia when used in combination with insulin and/or an insulin secretagogue. (نشرة سيتاغليبتين، التحذيرات والاحتياطات)

Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues: Increased risk of hypoglycemia when used in combination with insulin and/or an insulin secretagogue. (نشرة سيتاغليبتين وميتفورمين، التحذيرات والاحتياطات)

• Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin : May increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة سيماغلوتيد، التحذيرات والاحتياطات)

Hypoglycemia in Patients with Insulinoma: In patients with insulinoma, administration may produce an initial increase in blood glucose; however, glucagon may stimulate exaggerated insulin release from an insulinoma and cause hypoglycemia. (نشرة غلوكاغون، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

• Effect of Smoking Cessation on Other Drugs: Pharmacokinetics or pharmacodynamics of certain drugs (e.g., theophylline, warfarin, insulin) may be altered, necessitating dose adjustment. (نشرة فارينيكلين، التداخلات الدوائية)

Hydrochlorothiazide: When administered concurrently, the following drugs may interact with thiazide diuretics: Antidiabetic Drugs (oral agents and insulin) - Dosage adjustment of the antidiabetic drug may be required. (نشرة فالسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (نشرة فلودروكورتيزون، التداخلات الدوائية)

As is true with many other types of medication when taken concurrently by patients with diabetes, insulin and/or oral hypoglycemic, dosage may need to be adjusted when therapy with PROZAC is instituted or discontinued. (نشرة فلوكسيتين، التحذيرات والاحتياطات)

Sulfonylurea Oral Hypoglycemics (CYP2C9 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Frequent monitoring of blood glucose and for signs and symptoms of hypoglycemia. (نشرة فوريكونازول، التداخلات الدوائية)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (نشرة فوسامبرينافير، التحذيرات والاحتياطات)

Insulin requirements in diabetic patients may be increased, decreased, or unchanged. (نشرة فوسينوبريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

• A reduction in dose of insulin or oral hypoglycemic medication may be required in some patients. (نشرة فينترمين، التحذيرات والاحتياطات)

Closely monitor for adverse reactions of CYP2C9 substrates where minimal concentration changes may lead to serious adverse reactions when used concomitantly with XELODA (e.g., anticoagulants, antidiabetic drugs). (نشرة كابيسيتابين، التداخلات الدوائية)

Insulin and oral hypoglycemics action may be enhanced. (نشرة كارفيديلول، التداخلات الدوائية)

During the 8-week trial, serum insulin levels increased by 12 pmol/L in the VRAYLAR 1 mg to 2 mg per day group, 20 pmol/L in the VRAYLAR 2 mg to 4.5 mg per day group, and 8.5 pmol/L in the placebo group. (نشرة كاريبرازين، التحذيرات والاحتياطات)

• Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues : Consider a lower dose of insulin or the insulin secretagogue to reduce the risk of hypoglycemia when used in combination with INVOKANA ( 5.5 ). (نشرة كاناغليفلوزين، التحذيرات والاحتياطات)

Antidiabetic drugs (oral agents and insulin) − Dosage adjustment of the antidiabetic drug may be required. (نشرة كانديسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

Oral Hypoglycemic Agents/Insulin: The concomitant use of clarithromycin tablets and oral hypoglycemic agents and/or insulin can result in significant hypoglycemia. (نشرة كلاريثرومايسين، التحذيرات والاحتياطات)

Antidiabetic Drugs (Oral Agents and Insulin) - dosage adjustment of the antidiabetic drug may be required. (نشرة كلوروثيازيد، التداخلات الدوائية)

…placebo) and when colesevelam hydrochloride was used in combination with pioglitazone (median increase 11% compared to placebo in combination with pioglitazone), sulfonylureas (median increase 18% compared to placebo in combination with sulfonylureas), and insulin (median increase 22% compared to placebo in combination with insulin) [see Adverse Reactions (6.1) ]. (نشرة كوليسيفيلام، التحذيرات والاحتياطات)

Antidiabetics repaglinide, saxagliptin Antihelmintics and Antiprotozoals praziquantel Antimigraine Drugs ergot alkaloids, such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine) eletriptan Ergot alkaloids: The potential increase in plasma concentrations of ergot alkaloids when coadministered with ketoconazole tablets… (نشرة كيتوكونازول، التداخلات الدوائية)

Hypoglycemia Quinine stimulates release of insulin from the pancreas, and patients, especially pregnant women, may experience clinically significant hypoglycemia. (نشرة كينين، التحذيرات والاحتياطات)

Hyperglycemia and Hypoglycemia : Glucose monitoring is recommended and antidiabetic treatment adjusted accordingly. (نشرة لانريوتيد، التحذيرات والاحتياطات)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (نشرة لوبينافير وريتونافير، التحذيرات والاحتياطات)

Antidiabetic drugs: dosage adjustment of antidiabetic may be required. (نشرة لوسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

• Hypoglycemia : Adult patients taking an insulin secretagogue or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. (نشرة ليراغلوتيد، التحذيرات والاحتياطات)

Antidiabetics Concomitant administration of Zestril and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased blood-glucose-lowering effect with risk of hypoglycemia. (نشرة ليزينوبريل، التداخلات الدوائية)

Antidiabetic drugs (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required. (نشرة ليزينوبريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Blood Glucose Disturbances Fluoroquinolones, including Levofloxacin in 5% Dextrose Injection, have been associated with disturbances of blood glucose, including symptomatic hyperglycemia and hypoglycemia, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin. (نشرة ليفوفلوكساسين، التحذيرات والاحتياطات)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Hypoglycemia: Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating TRADJENTA ( 5.2 ) (نشرة ليناغليبتين، التحذيرات والاحتياطات)

Hypoglycemia: Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating JENTADUETO XR. (نشرة ليناغليبتين وميتفورمين، التحذيرات والاحتياطات)

• Hypoglycemia: Postmarketing cases of symptomatic hypoglycemia have been reported in patients with diabetes mellitus receiving insulin or oral hypoglycemic agents. (نشرة لينزوليد، التحذيرات والاحتياطات)

Antidiabetic agents Carefully monitor blood glucose. (نشرة موكسيفلوكساسين، التداخلات الدوائية)

Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues : Increased risk of hypoglycemia when used in combination with insulin and/or an insulin secretagogue. (نشرة ميتفورمين، التحذيرات والاحتياطات)

Antidiabetic drugs: Dosage adjustment may be required. (نشرة ميتوبرولول وهيدروكلوروثيازيد، التداخلات الدوائية)

Insulin Clinical Impact Increased GI motility by metoclopramide may increase delivery of food to the intestines and increase blood glucose. (نشرة ميتوكلوبراميد، التداخلات الدوائية)

Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (نشرة ميتولازون، التداخلات الدوائية)

Antidiabetics : Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (نشرة ميثيل بريدنيزولون، التداخلات الدوائية)

Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (نشرة ميثيل تستوستيرون، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Hypoglycemia: Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia. (نشرة تيرزيباتيد، التحذيرات والاحتياطات)

Beta-blockade also reduces the release of insulin in response to hyperglycemia; therefore, it may be necessary to adjust the dose of antidiabetic drugs. (نشرة نادولول، التحذيرات)

Use of Antidiabetic Medications: Weight loss may cause hypoglycemia. (نشرة نالتريكسون وبوبروبيون، التحذيرات والاحتياطات)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation. (نشرة تيرزيباتيد، التداخلات الدوائية)

Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (نشرة هيدروكسي يوريا، التحذيرات والاحتياطات)

Antidiabetic drugs: Dosage adjustment of antidiabetic may be required (7.2) (نشرة هيدروكلوروثيازيد، التداخلات الدوائية)

Antidiabetic Agents Clinical Impact: Corticosteroids in supraphysiologic doses may increase blood glucose concentrations. (نشرة هيدروكورتيزون، التداخلات الدوائية)

Monitor patients on oral medications dependent on threshold concentrations for efficacy and those with a narrow therapeutic index (e.g., warfarin) when concomitantly administered with ZEPBOUND. (نشرة تيرزيباتيد، التداخلات الدوائية)

Such measures include the intravenous administration of sodium bicarbonate solution or oral or parenteral glucose with a rapid-acting insulin preparation. (نشرة أميلوريد، التحذيرات)

…been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine,… (نشرة برازوسين، التداخلات الدوائية)

Additional predisposing conditions include diabetes mellitus treated with oral hypoglycemic drugs or insulin, use of anorectic drugs, excessive use of alcohol, use of benzodiazepines, sedatives/hypnotics, or opiates. (نشرة بوبروبيون، التحذيرات والاحتياطات)

Hypoglycemic Agents: In adult diabetic patients under treatment with either sulfonylureas or insulin there is no change in the clinical effects of either TOLECTIN or the hypoglycemic agents. (نشرة تولميتين، التداخلات الدوائية)

Drug Interactions with Amlodipine In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. (نشرة تيلميسارتان وأملوديبين، التداخلات الدوائية)

Antidiabetic drug requirements (i.e., insulin) may be altered. (نشرة ديثيل بروبيون، التداخلات الدوائية)

In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. (نشرة زيبراسيدون، التحذيرات والاحتياطات)

Administration of intravenous calcium, bicarbonate, and glucose with insulin, with hyperventilation have resulted in successful resuscitation in some of the reported cases. (نشرة سكسينيل كولين، التحذيرات والاحتياطات)

Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (نشرة سلفاديازين، التداخلات الدوائية)

Hyperglycemia Hyperglycemia, resulting from the inhibitory effect of phenytoin (the active metabolite of CEREBYX) on insulin release, has been reported. (نشرة فوسفينيتوين، التحذيرات والاحتياطات)

Insulin and Oral Hypoglycemic Medications Requirements may be altered. (نشرة فينديميترازين، التداخلات الدوائية)

Hyperglycemia Hyperglycemia, resulting from the drug’s inhibitory effects on insulin release, has been reported. (نشرة فينيتوين، التحذيرات والاحتياطات)

In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. (نشرة كلوزابين، التحذيرات والاحتياطات)

Oral Hypoglycemic Agents In pharmacokinetic studies of lovastatin in hypercholesterolemic non-insulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide (see CLINICAL PHARMACOLOGY , Clinical Studies in Adults ). (نشرة لوفاستاتين، التداخلات الدوائية)

In an uncontrolled open-label trial of CAPLYTA for up to 1 year in adult patients with stable schizophrenia, the percentages of patients with shifts in fasting glucose and insulin values from normal to high were 8% and 12%, respectively. (نشرة لوماتيبيرون، التحذيرات والاحتياطات)

Moexipril hydrochloride has been used in clinical trials concomitantly with calcium-channel-blocking agents, diuretics, H 2 blockers, digoxin, oral hypoglycemic agents, and cholesterol-lowering agents. (نشرة موكسيبريل، التداخلات الدوائية)

Insulin requirements in diabetes mellitus may be altered in association with the use of methamphetamine and the concomitant dietary regimen. (نشرة ميثامفيتامين، التداخلات الدوائية)

Administer INCRELEX shortly before or after a meal or snack, because it has insulin-like hypoglycemic effects. (نشرة ميكاسيرمين، التحذيرات والاحتياطات)

Although the systemic absorption of miconazole following ORAVIG administration is minimal and plasma concentrations of miconazole are substantially lower than when given intravenously, the potential for interaction with drugs metabolized through CYP2C9 and CYP3A4 such as oral hypoglycemics, phenytoin, or ergot alkaloids cannot be ruled out. (نشرة ميكونازول، التداخلات الدوائية)

…been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements. (نشرة ميلرينون، التداخلات الدوائية)

Glucose Lowering Drugs Pioglitazone: Co-administration of pioglitazone for 7 days with 30 mg nifedipine ER administered orally q.d. for 4 days to male and female volunteers resulted in least square mean (90% CI) values for unchanged nifedipine of 0.83 (0.73-0.95) for C max and 0.88 (0.80-0.96) for AUC relative to nifedipine monotherapy. (نشرة نيفيديبين، الاحتياطات)

Glyburide Clinical Impact: While oxaprozin does alter the pharmacokinetics of glyburide, coadministration of oxaprozin to type II non-insulin dependent diabetic patients did not affect the area under the glucose concentration curve nor the magnitude or duration of control. (نشرة أوكسابروزين، التداخلات الدوائية)

Oral hypoglycemic agents Although sulindac and its sulfide metabolite are highly bound to protein, studies in which sulindac was given at a dose of 400 mg daily, have shown no clinically significant interaction with oral hypoglycemic agents. (نشرة سولينداك، التداخلات الدوائية)

Other interactions: Vardenafil hydrochloride tablets had no effect on the pharmacodynamics of glyburide (glucose and insulin concentrations) and warfarin (prothrombin time or other pharmacodynamic parameters). (نشرة فاردينافيل، التداخلات الدوائية)