التداخل بين كوكايين وديسلفيرام

Avoid using NUMBRINO in patients taking disulfiram.

Disulfiram: Disulfiram treatment increases plasma cocaine exposure.

Disulfiram Published literature reported that disulfiram treatment increased plasma cocaine exposure (AUC and C max ), by several folds after acute intranasal cocaine administration.

Another literature reported that co-administration of disulfiram increased AUC of plasma cocaine by several folds after intravenous cocaine administration [see Clinical Pharmacology ( 12.3 )] .