التداخل بين إيثينوديول ثنائي الأسيتات وإيثينيل إستراديول والتبغ والتدخين

Cigarette smoking increases the risk of serious adverse effects on the heart and blood vessels from oral contraceptive use.

This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite marked in women over 35 years of age.

WARNINGS Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use.

2-21 This increased risk is primarily in smokers or in women with other underlying risk factors for coronary artery disease such as hypertension, obesity, diabetes, and hypercholesterolemia.

Smoking in combination with oral contraceptive use has been reported to contribute substantially to the risk of myocardial infarction in women in their mid-thirties or older, with smoking accounting for the majority of excess cases.