Ethynodiol diacetate and ethinyl estradiol and Tobacco and smoking interaction
Ethynodiol diacetate and ethinyl estradiol and Tobacco and smoking: the Ethynodiol diacetate and ethinyl estradiol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Ethynodiol diacetate and ethinyl estradiol (Kelnor 1/35) label · effective 2023-02-04
Cigarette smoking increases the risk of serious adverse effects on the heart and blood vessels from oral contraceptive use.
This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite marked in women over 35 years of age.
WARNINGS Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use.
2-21 This increased risk is primarily in smokers or in women with other underlying risk factors for coronary artery disease such as hypertension, obesity, diabetes, and hypercholesterolemia.
Smoking in combination with oral contraceptive use has been reported to contribute substantially to the risk of myocardial infarction in women in their mid-thirties or older, with smoking accounting for the majority of excess cases.
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