Wechselwirkungen von Calcitriol

Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Fachinformation zu Calcitriol, Warnhinweise)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Table 2: Oral drugs that can be administered concomitantly with Ferric Citrate Tablets Amlodipine Aspirin Atorvastatin Calcitriol Clopidogrel Digoxin Diltiazem Doxercalciferol Enalapril Fluvastatin Glimepiride Levofloxacin Losartan Metoprolol Pravastatin Propranolol Sitagliptin Warfarin Oral drugs that have to be separated from Ferric Citrate Tablets and meals… (Fachinformation zu Eisen(III)-citrat, Arzneimittelwechselwirkungen)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Fachinformation zu Calcitriol, Warnhinweise)

Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Fachinformation zu Calcitriol, Warnhinweise)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Calcium Supplements Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Magnesium-containing preparations (e.g., antacids) and calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia. (Fachinformation zu Calcitriol, Warnhinweise)

CONTRAINDICATIONS Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. (Fachinformation zu Calcitriol, Gegenanzeigen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Use of Miacalcin injection for the treatment of Paget’s disease or postmenopausal osteoporosis is recommended in conjunction with an adequate intake of calcium and vitamin D [see Dosage and Administration (2.5) ] . (Fachinformation zu Calcitonin (Lachs), Warnhinweise und Vorsichtsmaßnahmen)

Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (Fachinformation zu Calciumchlorid, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

If corrected serum calcium falls below the lower limit of normal or symptoms of hypocalcemia develop, start or increase calcium supplementation (including calcium, calcium-containing phosphate binders, and/or vitamin D sterols or increases in dialysate calcium concentration). (Fachinformation zu Cinacalcet, Warnhinweise und Vorsichtsmaßnahmen)

DRUG INTERACTIONS Cholestyramine Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of calcitriol (see WARNINGS and PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism. (Fachinformation zu Danazol, Arzneimittelwechselwirkungen)

Monitor calcium levels during therapy, especially in the first weeks of initiating therapy, and adequately supplement all patients with calcium and vitamin D. (Fachinformation zu Denosumab, Warnhinweise und Vorsichtsmaßnahmen)

Digitalis Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias (see PRECAUTIONS: General ). (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Hypercalcemia may be exacerbated by concomitant administration of high doses of calcium-containing preparations, thiazide diuretics, or other vitamin D compounds [see Drug Interactions ( 7 )]. (Fachinformation zu Doxercalciferol, Warnhinweise und Vorsichtsmaßnahmen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Other Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D Drugs whose level is decreased by phenytoin Anticoagulants Apixaban, dabigatran, edoxaban, rivaroxaban Antiepileptic drugs The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels… (Fachinformation zu Fosphenytoin, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Instruct patients to take supplemental calcium and vitamin D if their dietary intake is inadequate (see Dosage and Administration [2.3] ) . (Fachinformation zu Ibandronsäure, Warnhinweise und Vorsichtsmaßnahmen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (Fachinformation zu Orlistat, Arzneimittelwechselwirkungen)

• Electrolyte disorders (e.g., hypophosphatemia, hypokalemia, hypomagnesemia, hypocalcemia): Monitor phosphorus, potassium, magnesium, calcium and vitamin D and adequately supplement as appropriate. (Fachinformation zu Pamidronsäure, Warnhinweise und Vorsichtsmaßnahmen)

Hypercalcemia may be exacerbated by concomitant administration of high doses of calcium-containing preparations, thiazide diuretics, or other vitamin D compounds [see Drug Interactions (7) ] . (Fachinformation zu Paricalcitol, Warnhinweise und Vorsichtsmaßnahmen)

Phenytoin/Phenobarbital The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Phenytoin/Phenobarbital The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Phenytoin/Phenobarbital The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Calcium Supplements/Antacids When Risedronate sodium delayed-release was administered following breakfast, the co-administration of a tablet containing 600 mg of elemental calcium and 400 international units vitamin D reduced risedronate bioavailability by approximately 38% [ see Clinical Pharmacology (12.3) ] . (Fachinformation zu Risedronsäure, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

All patients should be instructed about the symptoms of hypocalcemia and the importance of calcium and vitamin D supplementation in maintaining serum calcium levels [see Dosage and Administration ( 2.8 ), Adverse Reactions ( 6.1 ), Patient Counseling Information ( 17 )]. (Fachinformation zu Zoledronsäure, Warnhinweise und Vorsichtsmaßnahmen)

Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (Fachinformation zu Alendronsäure, Warnhinweise und Vorsichtsmaßnahmen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (Fachinformation zu Calciumgluconat, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Serum parathyroid hormone levels and 1,25 Vitamin D levels were also higher in subjects receiving TDF. (Fachinformation zu Efavirenz, Lamivudin und Tenofovir, Warnhinweise und Vorsichtsmaßnahmen)

Serum parathyroid hormone levels and 1,25 Vitamin D levels were also higher in subjects receiving TDF. (Fachinformation zu Emtricitabin, Rilpivirin und Tenofovir, Warnhinweise und Vorsichtsmaßnahmen)

• Routine assessment of 25-hydroxy vitamin D levels prior to the start of aromatase inhibitor treatment should be performed ( 5.2 ). (Fachinformation zu Exemestan, Warnhinweise und Vorsichtsmaßnahmen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Other Medications Used for the Management of Fanconi Syndrome PROCYSBI can be administered with other electrolyte and mineral replacements necessary for management of Fanconi syndrome, as well as vitamin D and thyroid hormone. (Fachinformation zu Mercaptamin (Cysteamin), Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)

Serum parathyroid hormone levels and 1,25 Vitamin D levels were also higher in subjects receiving VIREAD. (Fachinformation zu Tenofovir, Warnhinweise und Vorsichtsmaßnahmen)

Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (Fachinformation zu Calcitriol, Arzneimittelwechselwirkungen)