Acamprosate interactions

Acamprosate (Campral) has 12 documented interactions across the FDA labels and fact sheets we index: 0 major, 0 moderate, 1 minor, and 11 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

What Acamprosate looks like

All 6 versions

Acamprosate 333 mg tablet: white, round, 10 mm, imprinted 333. — 333
333 mg · white · round · 10 mm
Carilion Materials Managem…

Acamprosate 333 mg tablet: white, round, 10 mm, imprinted 569. — 569
333 mg · white · round · 10 mm
Zydus Pharmaceuticals (USA)

Acamprosate 333 mg tablet: white, round, 10 mm, imprinted 435. — 435
333 mg · white · round · 10 mm
Glenmark Pharmaceuticals

Acamprosate 333 mg tablet: white, round, 10 mm, imprinted AC476. — AC476
333 mg · white · round · 10 mm
Somerset Therapeutics

Renderings from the FDA labels' product listings: color, shape, size, and imprint. 6 documented versions from 7 labelers.

Interactions from the label

Minor mentions (1)

AlcoholAlcoholMinor
Alcohol Withdrawal Use of acamprosate calcium does not eliminate or diminish withdrawal symptoms. (Acamprosate label, Warnings and precautions)

No significant interaction reported (11)

Alvimopanopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
DiazepambenzodiazepineNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
DisulfiramCYP2C9 inhibitorNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Methylnaltrexoneopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Naldemedineopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Nalmefeneopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Naloxegolopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Naloxoneopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Naltrexoneopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Naltrexone and bupropionopioid antagonistNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)
Pentazocine and naloxoneopioidNo interaction
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology ( 12.3 ) ]. (Acamprosate label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.