Ampicillin interactions

Ampicillin (Principen), a penicillin antibiotic has 71 documented interactions across the FDA labels and fact sheets we index: 14 major, 27 moderate, 29 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (14)

  • Amoxicillinpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefadroxilcephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefdinircephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefiximecephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefpodoximecephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefuroximecephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CephalexincephalosporinMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Dicloxacillinpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Doxycyclinetetracycline antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • Minocyclinetetracycline antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Penicillin Gpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Penicillin Vpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Tetracyclinetetracycline antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

Moderate interactions (27)

  • Allopurinolxanthine oxidase inhibitorModerate

    Allopurinol : Substantially increased incidence of skin rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. (Ampicillin label, Drug interactions)

  • Bisoprolol and hydrochlorothiazidebeta blockerModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Bisoprolol and hydrochlorothiazide label, Warnings)

  • ChloroquineantimalarialModerate

    Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. (Chloroquine label, Drug interactions)

  • Cholestyraminebile acid sequestrantModerate

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

  • Conjugated estrogensestrogenModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Drospirenone and ethinyl estradioloral contraceptiveModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • EstradiolestrogenModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Hydrochlorothiazide label, Warnings and precautions)

  • HydroxychloroquineQT-prolonging drugModerate

    Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. (Hydroxychloroquine label, Drug interactions)

  • LeflunomideimmunosuppressantModerate

    In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Leflunomide label, Drug interactions)

  • LevonorgestrelprogestinModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Levonorgestrel and ethinyl estradioloral contraceptiveModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Lisinopril and hydrochlorothiazideACE inhibitorModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Lisinopril and hydrochlorothiazide label, Warnings)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Losartan and hydrochlorothiazide label, Warnings and precautions)

  • MedroxyprogesteroneprogestinModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • MegestrolprogestinModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • MethotrexateimmunosuppressantModerate

    Effect of Other Drugs on XATMEP Oral Antibiotics Penicillins may reduce the renal clearance of methotrexate; increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with methotrexate. (Methotrexate label, Drug interactions)

  • MycophenolateimmunosuppressantModerate

    Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing MYHIBBIN… (Mycophenolate label, Drug interactions)

  • NorethindroneprogestinModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Norethindrone and ethinyl estradioloral contraceptiveModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • ProgesteroneprogestinModerate

    Oral Contraceptives : May be less effective and increased breakthrough bleeding may occur. (Ampicillin label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Spironolactone and hydrochlorothiazide label, Warnings)

  • TeriflunomideimmunosuppressantModerate

    In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Teriflunomide label, Drug interactions)

  • Triamterenepotassium-sparing diureticModerate

    …from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (Triamterene label, Drug interactions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Triamterene and hydrochlorothiazide label, Warnings)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Valsartan and hydrochlorothiazide label, Warnings and precautions)

Minor mentions (29)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • BeclomethasonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • BetamethasonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • BudesonidecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • Budesonide and formoterolcorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • ClobetasolcorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • DesonidecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • DexamethasonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • Dorzolamidecarbonic anhydrase inhibitorMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • EpinephrinesympathomimeticMinor

    SERIOUS ANAPHYLACTIC REACTIONS REQUIRE IMMEDIATE EMERGENCY TREATMENT WITH EPINEPHRINE. (Ampicillin label, Warnings)

  • Erythromycinmacrolide antibioticMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • FludrocortisonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • FluocinonidecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • FluticasonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • Fluticasone and salmeterolcorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • HalobetasolcorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • HydrocortisonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • MethylprednisolonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • MometasonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • NeomycinaminoglycosideMinor

    Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. (Neomycin label, Drug interactions)

  • PrednisolonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • PrednisonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • Raloxifeneselective estrogen receptor modulatorMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)

  • Silver sulfadiazinesulfonamideMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • Sulfamethoxazole and trimethoprimsulfonamideMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • SulfasalazinesulfonamideMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • TriamcinolonecorticosteroidMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (Ampicillin label, Warnings)

  • ZonisamideanticonvulsantMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

No significant interaction reported (1)

  • TheophyllinemethylxanthineNo interaction

    …interact with theophylline or drugs that produce no clinically significant interaction with theophylline.* albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without methylprednisolone sulbactam metronidazole atenolol metoprolol azithromycin nadolol caffeine, dietary ingestion nifedipine cefaclor nizatidine co-trimoxazole… (Theophylline label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.