Interaction Checker

Protamine : interactions médicamenteuses

Protamine présente 81 interactions documentées dans les notices FDA et les fiches d'information que nous indexons : 51 de niveau majeur, 26 de niveau modéré, 0 de niveau mineur et 4 cas où une notice ne signale aucune interaction significative. Chaque entrée ci-dessous cite la phrase sur laquelle elle repose. Cette page consacrée à un médicament est un point de départ, pas un verdict sur votre situation.

Interactions d'après la notice

Interactions majeures (51)

  • AcébutololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Acide aminocaproïqueantifibrinolytiqueMajeure

    • Protamine paracoagulation test is positive in DIC; a precipitate forms when protamine sulfate is dropped into citrated plasma. (notice Acide aminocaproïque, Contre-indications)

  • AdrénalinesympathomimétiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Amfépramonestimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Articaïne et adrénalineanesthésique localMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • AténololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Aténolol et chlortalidonebêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Benzfétaminestimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • BétaxololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • BisoprololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Bisoprolol et hydrochlorothiazidebêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Brimonidine et timololagoniste alpha-adrénergiqueMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Bromphéniramine, pseudoéphédrine et dextrométhorphaneantihistaminiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Bupivacaïne et adrénalineanesthésique localMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • CarvédilolbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • DobutaminesympathomimétiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Dorzolamide et timololinhibiteur de l'anhydrase carboniqueMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • DroxidopasympathomimétiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • ÉnoxaparineanticoagulantMajeure

    Protamine sulfate should not be given when bleeding occurs without prior heparin use. (notice Protamine, Mise en garde encadrée)

  • ÉphédrinesympathomimétiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • EsmololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • HéparineanticoagulantMajeure

    Protamine sulfate should not be given when bleeding occurs without prior heparin use. (notice Protamine, Mise en garde encadrée)

  • Insuline asparteinsulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Insuline dégludecinsulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Insuline détémirinsulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Insuline glargineinsulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Insuline lisproinsulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Insuline rapide (humaine)insulineMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Isoprénalineagoniste bêta-adrénergiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • LabétalolbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Lidocaïne et adrénalineanesthésique localMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Méthamphétaminestimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • MétoprololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Métoprolol et hydrochlorothiazidebêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Midodrineagoniste alpha-adrénergiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Mirabégronagoniste bêta-adrénergiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Modafinilstimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • NadololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • NébivololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • OxymétazolinedécongestionnantMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Phendimétrazinestimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • Phenterminestimulant du SNCMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • PhényléphrinedécongestionnantMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • PindololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Prilocaïne et adrénalineanesthésique localMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • PropranololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • PseudoéphédrinedécongestionnantMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

  • SotalolbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • TimololbêtabloquantMajeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Tirzépatideagoniste du récepteur du GLP-1Majeure

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (notice Protamine, Mise en garde encadrée)

  • Vibégronagoniste bêta-adrénergiqueMajeure

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (notice Protamine, Mise en garde encadrée)

Interactions modérées (26)

  • Amoxicillineantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Amoxicilline et acide clavulaniqueantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Ampicillineantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Ampicilline et sulbactamantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfaclorcéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfadroxilcéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfalexinecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfazolinecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CefdinircéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfépimecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfiximecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfotaximecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfotétancéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfoxitinecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CefpodoximecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CefprozilcéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CeftarolinecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CeftazidimecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CeftriaxonecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • CéfuroximecéphalosporineModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Dicloxacillineantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Nafcillineantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Oxacillineantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Pénicilline Gantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Pénicilline Vantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

  • Pipéracilline et tazobactamantibiotique de la famille des pénicillinesModérée

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (notice Protamine, Précautions)

Aucune interaction significative signalée (4)

  • ApixabananticoagulantAucune interaction

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of apixaban. (notice Apixaban, Mises en garde et précautions)

  • DabigatrananticoagulantAucune interaction

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of dabigatran. (notice Dabigatran, Mises en garde et précautions)

  • ÉdoxabananticoagulantAucune interaction

    Protamine sulfate, vitamin K, and tranexamic acid are not expected to reverse the anticoagulant activity of SAVAYSA. (notice Édoxaban, Mises en garde et précautions)

  • RivaroxabananticoagulantAucune interaction

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of rivaroxaban. (notice Rivaroxaban, Mises en garde et précautions)

Vérifiez Protamine avec tout ce que vous prenez. Ajoutez votre liste complète ; toutes les paires sont vérifiées en une fois.

Ouvrir dans le vérificateur

Ceci n'est pas un avis médical. Le niveau de gravité reflète la formulation de la notice, pas votre situation. Une alerte « majeure » peut être courante sous surveillance et une alerte « mineure » peut compter à forte dose. Demandez conseil à un pharmacien.