Interaction Checker

Interações de Protamina

Protamina tem 81 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 51; moderadas: 26; leves: 0; casos em que uma bula relata não haver interação significativa: 4). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (51)

  • AcebutololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Ácido aminocaproicoantifibrinolíticoGrave

    • Protamine paracoagulation test is positive in DIC; a precipitate forms when protamine sulfate is dropped into citrated plasma. (bula de Ácido aminocaproico, Contraindicações)

  • Anfepramona (dietilpropiona)estimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Articaína + epinefrinaanestésico localGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • AtenololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Atenolol + clortalidonabetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Benzfetaminaestimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • BetaxololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • BisoprololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Bisoprolol + hidroclorotiazidabetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Brimonidina + timololagonista alfa-adrenérgicoGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Bronfeniramina + pseudoefedrina + dextrometorfanoanti-histamínicoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Bupivacaína + epinefrinaanestésico localGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • CarvedilolbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • DobutaminasimpaticomiméticoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Dorzolamida + timololinibidor da anidrase carbônicaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • DroxidopasimpaticomiméticoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • EfedrinasimpaticomiméticoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • EnoxaparinaanticoagulanteGrave

    Protamine sulfate should not be given when bleeding occurs without prior heparin use. (bula de Protamina, Advertência em caixa preta)

  • Epinefrina (adrenalina)simpaticomiméticoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • EsmololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Fendimetrazinaestimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • FenilefrinadescongestionanteGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Fenterminaestimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • HeparinaanticoagulanteGrave

    Protamine sulfate should not be given when bleeding occurs without prior heparin use. (bula de Protamina, Advertência em caixa preta)

  • Insulina asparteinsulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Insulina degludecainsulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Insulina detemirinsulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Insulina glarginainsulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Insulina lisproinsulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Insulina regular (humana)insulinaGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Isoprenalina (isoproterenol)agonista beta-adrenérgicoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • LabetalolbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Lidocaína + epinefrinaanestésico localGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Metanfetaminaestimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • MetoprololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Metoprolol + hidroclorotiazidabetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Midodrinaagonista alfa-adrenérgicoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Mirabegronaagonista beta-adrenérgicoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • Modafinilaestimulante do SNCGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • NadololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • NebivololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • OximetazolinadescongestionanteGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • PindololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Prilocaína + epinefrinaanestésico localGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • PropranololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • PseudoefedrinadescongestionanteGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

  • SotalolbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • TimololbetabloqueadorGrave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Tirzepatidaagonista do receptor de GLP-1Grave

    Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

  • Vibegronaagonista beta-adrenérgicoGrave

    Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (bula de Protamina, Advertência em caixa preta)

Interações moderadas (26)

  • Amoxicilinaantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Amoxicilina + clavulanato de potássioantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Ampicilinaantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Ampicilina + sulbactamantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Benzilpenicilina (penicilina G)antibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefaclorcefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefadroxilacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefalexinacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefazolinacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefdinircefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefepimacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefiximacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefotaximacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefotetanacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefoxitinacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefpodoximacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefprozilacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CeftarolinacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CeftazidimacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CeftriaxonacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • CefuroximacefalosporinaModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Dicloxacilinaantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Fenoximetilpenicilina (penicilina V)antibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Nafcilinaantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Oxacilinaantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

  • Piperacilina + tazobactamantibiótico da classe das penicilinasModerada

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)

Nenhuma interação significativa relatada (4)

  • ApixabanaanticoagulanteSem interação

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of apixaban. (bula de Apixabana, Advertências e precauções)

  • DabigatranaanticoagulanteSem interação

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of dabigatran. (bula de Dabigatrana, Advertências e precauções)

  • EdoxabanaanticoagulanteSem interação

    Protamine sulfate, vitamin K, and tranexamic acid are not expected to reverse the anticoagulant activity of SAVAYSA. (bula de Edoxabana, Advertências e precauções)

  • RivaroxabanaanticoagulanteSem interação

    Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of rivaroxaban. (bula de Rivaroxabana, Advertências e precauções)

Verifique Protamina com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

Abrir no verificador

Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.