Tigécycline : interactions médicamenteuses

Tigécycline (Tygacil), antibiotique de la famille des tétracyclines, présente 61 interactions documentées dans les notices FDA et les fiches d'information que nous indexons : 8 de niveau majeur, 19 de niveau modéré, 31 de niveau mineur et 3 cas où une notice ne signale aucune interaction significative. Chaque entrée ci-dessous cite la phrase sur laquelle elle repose. Cette page consacrée à un médicament est un point de départ, pas un verdict sur votre situation.

Interactions d'après la notice

Interactions majeures (8)

  • AcitrétinerétinoïdeMajeure

    Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated (see WARNINGS: Pseudotumor Cerebri ). (notice Acitrétine, Contre-indications)

  • CiclosporineimmunosuppresseurMajeure

    Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)

  • IsotrétinoïnerétinoïdeMajeure

    Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (notice Isotrétinoïne, Mises en garde et précautions)

  • Pénicilline Gantibiotique de la famille des pénicillinesMajeure

    Drug Interactions Bacteriostatic antibacterials ( i.e. , chloramphenicol, erythromycins, sulfonamides or tetracyclines) may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. (notice Pénicilline G, Interactions médicamenteuses)

  • Pimécrolimusinhibiteur de la calcineurineMajeure

    Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)

  • Avoid use in patients with known hypersensitivity to tetracyclines. (notice Tigécycline, Mises en garde et précautions)

  • TacrolimusimmunosuppresseurMajeure

    Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)

  • Tétracyclineantibiotique de la famille des tétracyclinesMajeure

    Avoid use in patients with known hypersensitivity to tetracyclines. (notice Tigécycline, Mises en garde et précautions)

Interactions modérées (19)

  • Acétate de calciumchélateur du phosphateModérée

    Calcium acetate capsules may decrease the bioavailability of tetracyclines or fluoroquinolones via this mechanism. (notice Acétate de calcium, Interactions médicamenteuses)

  • AtovaquoneantipaludiqueModérée

    • Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering. (notice Atovaquone, Interactions médicamenteuses)

  • Atovaquone et proguanilantipaludiqueModérée

    • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (notice Atovaquone et proguanil, Interactions médicamenteuses)

  • CalciumVitamines et minérauxModérée

    Le calcium se lie à ces médicaments dans l'intestin et peut fortement réduire la quantité absorbée ; espacez les prises. (NIH Office of Dietary Supplements, Calcium)

  • Colestipolchélateur des acides biliairesModérée

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (notice Colestipol, Interactions médicamenteuses)

  • Colestyraminechélateur des acides biliairesModérée

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (notice Colestyramine, Interactions médicamenteuses)

  • FerVitamines et minérauxModérée

    Le fer se lie à ces médicaments dans l'intestin et réduit leur absorption ; espacez les prises. (NIH Office of Dietary Supplements, Iron)

  • Glimépiridesulfamide hypoglycémiantModérée

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (notice Glimépiride, Interactions médicamenteuses)

  • Lanthanechélateur du phosphateModérée

    Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (notice Lanthane, Interactions médicamenteuses)

  • LomitapideModérée

    Caution should be exercised when JUXTAPID is used with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen. (notice Lomitapide, Mises en garde et précautions)

  • MagnésiumVitamines et minérauxModérée

    Les compléments et les antiacides contenant du magnésium réduisent l'absorption de ces médicaments ; espacez les prises d'au moins deux heures. (NIH Office of Dietary Supplements, Magnesium)

  • Pioglitazone et glimépiridethiazolidinedioneModérée

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (notice Pioglitazone et glimépiride, Interactions médicamenteuses)

  • Quinaprilinhibiteur de l'enzyme de conversion (IEC)Modérée

    Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (notice Quinapril, Interactions médicamenteuses)

  • QuinineantipaludiqueModérée

    Although tetracycline may be concomitantly administered with quinine sulfate, patients should be monitored closely for adverse reactions associated with quinine sulfate. (notice Quinine, Interactions médicamenteuses)

  • Rocuroniumbloquant neuromusculaireModérée

    Antibiotics Drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as Rocuronium Bromide Injection include certain antibiotics (e.g., aminoglycosides; vancomycin; tetracyclines; bacitracin; polymyxins; colistin; and sodium colistimethate). (notice Rocuronium, Interactions médicamenteuses)

  • SucralfateModérée

    Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (notice Sucralfate, Interactions médicamenteuses)

  • TrétinoïnerétinoïdeModérée

    The concomitant use of other products (e.g., tetracyclines) that can cause intracranial hypertension may increase the risk. (notice Trétinoïne, Mises en garde et précautions)

  • WarfarineanticoagulantModérée

    • Warfarin : Suitable anticoagulation test should be monitored if TYGACIL is administered to patients receiving warfarin. (notice Tigécycline, Interactions médicamenteuses)

  • ZincVitamines et minérauxModérée

    Le zinc réduit l'absorption des antibiotiques de la famille des quinolones et des tétracyclines ; prenez l'antibiotique au moins deux heures avant ou quatre à six heures après le zinc. (NIH Office of Dietary Supplements, Zinc)

Mentions mineures (31)

  • Amoxicillineantibiotique de la famille des pénicillinesMineure

    Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (notice Amoxicilline, Interactions médicamenteuses)

  • Ampicillineantibiotique de la famille des pénicillinesMineure

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (notice Ampicilline, Interactions médicamenteuses)

  • Déméclocyclineantibiotique de la famille des tétracyclinesMineure

    WARNINGS DEMECLOCYCLINE HYDROCHLORIDE, LIKE OTHER TETRACYCLINE-CLASS ANTIBIOTICS, CAN CAUSE FETAL HARM WHEN ADMINISTERED TO A PREGNANT WOMAN. (notice Déméclocycline, Mises en garde)

  • Désogestrel et éthinylestradiolcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Dicloxacillineantibiotique de la famille des pénicillinesMineure

    Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (notice Dicloxacilline, Interactions médicamenteuses)

  • Drospirénone et éthinylestradiolcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • EstradiolestrogèneMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Estradiol et diénogestcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Estrogènes conjuguésestrogèneMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • FulvestrantestrogèneMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • HéparineanticoagulantMineure

    Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (notice Héparine, Interactions médicamenteuses)

  • Imipénem et cilastatineantibiotiqueMineure

    In cIAI studies (n=1642), 6 patients treated with TYGACIL and 2 patients treated with imipenem/cilastatin presented with intestinal perforations and developed sepsis/septic shock. (notice Tigécycline, Mises en garde et précautions)

  • LévonorgestrelprogestatifMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Lévonorgestrel et éthinylestradiolcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • MédroxyprogestéroneprogestatifMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • MégestrolprogestatifMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Mifépristoneinhibiteur du CYP3A4Mineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Nafcillineantibiotique de la famille des pénicillinesMineure

    Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. (notice Nafcilline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • NoréthistéroneprogestatifMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Norgestimate et éthinylestradiolcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Norgestrel et éthinylestradiolcontraceptif oralMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Oxacillineantibiotique de la famille des pénicillinesMineure

    Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (notice Oxacilline, Interactions médicamenteuses)

  • ProgestéroneprogestatifMineure

    Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)

  • Vécuroniumbloquant neuromusculaireMineure

    The following antibiotics have been associated with various degrees of paralysis: aminoglycosides (such as neomycin, streptomycin, kanamycin, gentamicin, and dihydrostreptomycin); tetracyclines; bacitracin; polymyxin B; colistin; and sodium colistimethate. (notice Vécuronium, Précautions)

Aucune interaction significative signalée (3)

  • AminophyllineméthylxanthineAucune interaction

    …omeprazole prednisone, prednisolone ranitidine rifabutin roxithromycin sorbitol (purgative doses do not inhibit theophylline absorption) sucralfate terbutaline, systemic terfenadine tetracycline tocainide The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific… (notice Aminophylline, Interactions médicamenteuses)

  • Cisatracuriumbloquant neuromusculaireAucune interaction

    …additional doses of Cisatracurium Besylate Injection, and to determine whether adjustments need to be made to the dose with subsequent administration. † Examples: aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, sodium colistimethate Drug or Drug Class Clinical Implications * Succinylcholine The use of succinylcholine… (notice Cisatracurium, Interactions médicamenteuses)

  • ThéophyllineméthylxanthineAucune interaction

    …ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (notice Théophylline, Interactions médicamenteuses)

Vérifiez Tigécycline avec tout ce que vous prenez. Ajoutez votre liste complète ; toutes les paires sont vérifiées en une fois.

Ouvrir dans le vérificateur

Ceci n'est pas un avis médical. Le niveau de gravité reflète la formulation de la notice, pas votre situation. Une alerte « majeure » peut être courante sous surveillance et une alerte « mineure » peut compter à forte dose. Demandez conseil à un pharmacien.