Tigécycline : interactions médicamenteuses
Tigécycline (Tygacil), antibiotique de la famille des tétracyclines, présente 61 interactions documentées dans les notices FDA et les fiches d'information que nous indexons : 8 de niveau majeur, 19 de niveau modéré, 31 de niveau mineur et 3 cas où une notice ne signale aucune interaction significative. Chaque entrée ci-dessous cite la phrase sur laquelle elle repose. Cette page consacrée à un médicament est un point de départ, pas un verdict sur votre situation.
Interactions d'après la notice
Interactions majeures (8)
Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated (see WARNINGS: Pseudotumor Cerebri ). (notice Acitrétine, Contre-indications)
Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)
Intracranial Hypertension ( Pseudotumor Cerebri ): Avoid concomitant use with tetracyclines ( 5.5 ) (notice Isotrétinoïne, Mises en garde et précautions)
Drug Interactions Bacteriostatic antibacterials ( i.e. , chloramphenicol, erythromycins, sulfonamides or tetracyclines) may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. (notice Pénicilline G, Interactions médicamenteuses)
Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)
Avoid use in patients with known hypersensitivity to tetracyclines. (notice Tigécycline, Mises en garde et précautions)
Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with TYGACIL to avoid drug toxicity. (notice Tigécycline, Interactions médicamenteuses)
Avoid use in patients with known hypersensitivity to tetracyclines. (notice Tigécycline, Mises en garde et précautions)
Interactions modérées (19)
Calcium acetate capsules may decrease the bioavailability of tetracyclines or fluoroquinolones via this mechanism. (notice Acétate de calcium, Interactions médicamenteuses)
• Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering. (notice Atovaquone, Interactions médicamenteuses)
• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (notice Atovaquone et proguanil, Interactions médicamenteuses)
Le calcium se lie à ces médicaments dans l'intestin et peut fortement réduire la quantité absorbée ; espacez les prises. (NIH Office of Dietary Supplements, Calcium)
The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (notice Colestipol, Interactions médicamenteuses)
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (notice Colestyramine, Interactions médicamenteuses)
Le fer se lie à ces médicaments dans l'intestin et réduit leur absorption ; espacez les prises. (NIH Office of Dietary Supplements, Iron)
…antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (notice Glimépiride, Interactions médicamenteuses)
Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (notice Lanthane, Interactions médicamenteuses)
- LomitapideModérée
Caution should be exercised when JUXTAPID is used with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen. (notice Lomitapide, Mises en garde et précautions)
Les compléments et les antiacides contenant du magnésium réduisent l'absorption de ces médicaments ; espacez les prises d'au moins deux heures. (NIH Office of Dietary Supplements, Magnesium)
…antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (notice Pioglitazone et glimépiride, Interactions médicamenteuses)
Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (notice Quinapril, Interactions médicamenteuses)
Although tetracycline may be concomitantly administered with quinine sulfate, patients should be monitored closely for adverse reactions associated with quinine sulfate. (notice Quinine, Interactions médicamenteuses)
Antibiotics Drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as Rocuronium Bromide Injection include certain antibiotics (e.g., aminoglycosides; vancomycin; tetracyclines; bacitracin; polymyxins; colistin; and sodium colistimethate). (notice Rocuronium, Interactions médicamenteuses)
- SucralfateModérée
Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (notice Sucralfate, Interactions médicamenteuses)
The concomitant use of other products (e.g., tetracyclines) that can cause intracranial hypertension may increase the risk. (notice Trétinoïne, Mises en garde et précautions)
• Warfarin : Suitable anticoagulation test should be monitored if TYGACIL is administered to patients receiving warfarin. (notice Tigécycline, Interactions médicamenteuses)
Le zinc réduit l'absorption des antibiotiques de la famille des quinolones et des tétracyclines ; prenez l'antibiotique au moins deux heures avant ou quatre à six heures après le zinc. (NIH Office of Dietary Supplements, Zinc)
Mentions mineures (31)
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (notice Amoxicilline, Interactions médicamenteuses)
Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (notice Ampicilline, Interactions médicamenteuses)
WARNINGS DEMECLOCYCLINE HYDROCHLORIDE, LIKE OTHER TETRACYCLINE-CLASS ANTIBIOTICS, CAN CAUSE FETAL HARM WHEN ADMINISTERED TO A PREGNANT WOMAN. (notice Déméclocycline, Mises en garde)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (notice Dicloxacilline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (notice Héparine, Interactions médicamenteuses)
In cIAI studies (n=1642), 6 patients treated with TYGACIL and 2 patients treated with imipenem/cilastatin presented with intestinal perforations and developed sepsis/septic shock. (notice Tigécycline, Mises en garde et précautions)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. (notice Nafcilline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (notice Oxacilline, Interactions médicamenteuses)
Oral Contraceptives Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective. (notice Tigécycline, Interactions médicamenteuses)
The following antibiotics have been associated with various degrees of paralysis: aminoglycosides (such as neomycin, streptomycin, kanamycin, gentamicin, and dihydrostreptomycin); tetracyclines; bacitracin; polymyxin B; colistin; and sodium colistimethate. (notice Vécuronium, Précautions)
Aucune interaction significative signalée (3)
…omeprazole prednisone, prednisolone ranitidine rifabutin roxithromycin sorbitol (purgative doses do not inhibit theophylline absorption) sucralfate terbutaline, systemic terfenadine tetracycline tocainide The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific… (notice Aminophylline, Interactions médicamenteuses)
…additional doses of Cisatracurium Besylate Injection, and to determine whether adjustments need to be made to the dose with subsequent administration. † Examples: aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, sodium colistimethate Drug or Drug Class Clinical Implications * Succinylcholine The use of succinylcholine… (notice Cisatracurium, Interactions médicamenteuses)
…ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (notice Théophylline, Interactions médicamenteuses)
Vérifiez Tigécycline avec tout ce que vous prenez. Ajoutez votre liste complète ; toutes les paires sont vérifiées en une fois.
Ouvrir dans le vérificateurCeci n'est pas un avis médical. Le niveau de gravité reflète la formulation de la notice, pas votre situation. Une alerte « majeure » peut être courante sous surveillance et une alerte « mineure » peut compter à forte dose. Demandez conseil à un pharmacien.