Acide folique (folates) : interactions médicamenteuses

VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (notice Acide folinique, Contre-indications)

KHAPZORY is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid, or folinic acid [see Adverse Reactions ( 6.2 )] . (notice Acide lévofolinique, Contre-indications)

…Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents (usually in combination) Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (notice Phénytoïne, Interactions médicamenteuses)

Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency. (notice Pyriméthamine, Contre-indications)

Effects of Other Drugs on SEPHIENCE Avoid concomitant use of drugs known to inhibit folate synthesis dihydrofolate reductase (DHFR) (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, and piritrexim) while taking SEPHIENCE. (notice Sépiaptérine, Interactions médicamenteuses)

CONTRAINDICATIONS Sulfamethoxazole and trimethoprim is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency. (notice Sulfaméthoxazole et triméthoprime, Contre-indications)

CONTRAINDICATIONS Trimethoprim is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency. (notice Triméthoprime, Contre-indications)

Acetazolamide may increase the effects of other folic acid antagonists. (notice Acétazolamide, Interactions médicamenteuses)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population . (notice Acide valproïque, Mises en garde et précautions)

Leucovorin The concentration of fluorouracil is increased and its toxicity may be enhanced by leucovorin, folic acid, or folate analog products. (notice Capécitabine, Interactions médicamenteuses)

Ces médicaments antiépileptiques abaissent les taux de folates, et les compléments d'acide folique peuvent à leur tour abaisser les taux sanguins du médicament. (NIH Office of Dietary Supplements, Folate)

Folic acid antagonists have similar effects and may increase the incidence of hematologic reactions; if co-administered with dapsone the patient should be monitored more frequently. (notice Dapsone, Mises en garde)

…proteins may be elevated in the serum. d) Sex-steroid binding globulins are increased and result in elevated levels of total circulating sex steroids and corticoids; however, free or biologically active levels remain unchanged. e) Triglycerides and phospholipids may be increased. f) Glucose tolerance may be decreased. g) Serum folate levels may be depressed. (notice Diacétate d'étynodiol et éthinylestradiol, Précautions)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] . (notice Divalproate de sodium (valproate), Mises en garde et précautions)

…trazodone, warfarin Drugs that may decrease phenytoin serum levels Antineoplastic agents usually in combination Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (notice Fosphénytoïne, Interactions médicamenteuses)

Nitrous Oxide The use of nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, resulting in the potential for increase toxicity. (notice Méthotrexate, Interactions médicamenteuses)

Initiate supplementation with oral folic acid and intramuscular vitamin B 12 to reduce the severity of hematologic and gastrointestinal toxicity of PEMFEXY. (notice Pémétrexed, Mises en garde et précautions)

Ces médicaments antiépileptiques abaissent les taux de folates, et les compléments d'acide folique peuvent à leur tour abaisser les taux sanguins du médicament. (NIH Office of Dietary Supplements, Folate)

Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (notice Polymyxine B et triméthoprime (ophtalmique), Précautions)

Administer vitamin B 12 and instruct patients to take folic acid to reduce the risk of treatment-related myelosuppression [see Dosage and Administration ( 2.1 )]. (notice Pralatrexate, Mises en garde et précautions)

Ces médicaments antiépileptiques abaissent les taux de folates, et les compléments d'acide folique peuvent à leur tour abaisser les taux sanguins du médicament. (NIH Office of Dietary Supplements, Folate)

Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (notice Saproptérine, Interactions médicamenteuses)

Reductions in Vitamins D, E, K (clotting factors) and Folic Acid Levels In preclinical studies in rats and dogs, sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, reduced vitamins D, E, and K (coagulation parameters) and folic acid levels at doses of 6–10 times the recommended human dose. (notice Sévélamer, Mises en garde et précautions)

Drug Interactions: Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine. (notice Sulfasalazine, Interactions médicamenteuses)

Serum folate levels may be depressed by oral contraceptive therapy. (notice Désogestrel et éthinylestradiol, Précautions)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (notice Dobutamine, Interactions médicamenteuses)

The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. (notice Hydroxycarbamide, Mises en garde et précautions)

In RA, concomitant medications besides MTX were nonsteroidal anti-inflammatory agents (NSAIDs), folic acid, corticosteroids and/or narcotics. (notice Infliximab, Interactions médicamenteuses)

Interactions with Laboratory Tests Therapeutic concentrations of rifampin have been shown to inhibit standard microbiological assays for serum folate and Vitamin B 12 . (notice Rifapentine, Interactions médicamenteuses)