Interacciones de Ácido fólico (folato)

VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (etiqueta de Ácido folínico (leucovorina), Contraindicaciones)

KHAPZORY is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid, or folinic acid [see Adverse Reactions ( 6.2 )] . (etiqueta de Ácido levofolínico (levoleucovorina), Contraindicaciones)

…Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents (usually in combination) Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (etiqueta de Fenitoína, Interacciones medicamentosas)

Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency. (etiqueta de Pirimetamina, Contraindicaciones)

Effects of Other Drugs on SEPHIENCE Avoid concomitant use of drugs known to inhibit folate synthesis dihydrofolate reductase (DHFR) (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, and piritrexim) while taking SEPHIENCE. (etiqueta de Sepiapterina, Interacciones medicamentosas)

CONTRAINDICATIONS Sulfamethoxazole and trimethoprim is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency. (etiqueta de Sulfametoxazol y trimetoprima, Contraindicaciones)

CONTRAINDICATIONS Trimethoprim is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency. (etiqueta de Trimetoprima, Contraindicaciones)

Acetazolamide may increase the effects of other folic acid antagonists. (etiqueta de Acetazolamida, Interacciones medicamentosas)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population . (etiqueta de Ácido valproico, Advertencias y precauciones)

Leucovorin The concentration of fluorouracil is increased and its toxicity may be enhanced by leucovorin, folic acid, or folate analog products. (etiqueta de Capecitabina, Interacciones medicamentosas)

Estos fármacos antiepilépticos reducen los niveles de folato, y los suplementos de ácido fólico pueden a su vez reducir los niveles en sangre del fármaco. (NIH Office of Dietary Supplements, Folate)

Folic acid antagonists have similar effects and may increase the incidence of hematologic reactions; if co-administered with dapsone the patient should be monitored more frequently. (etiqueta de Dapsona, Advertencias)

…proteins may be elevated in the serum. d) Sex-steroid binding globulins are increased and result in elevated levels of total circulating sex steroids and corticoids; however, free or biologically active levels remain unchanged. e) Triglycerides and phospholipids may be increased. f) Glucose tolerance may be decreased. g) Serum folate levels may be depressed. (etiqueta de Diacetato de etinodiol y etinilestradiol, Precauciones)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] . (etiqueta de Divalproato de sodio (valproato), Advertencias y precauciones)

Estos fármacos antiepilépticos reducen los niveles de folato, y los suplementos de ácido fólico pueden a su vez reducir los niveles en sangre del fármaco. (NIH Office of Dietary Supplements, Folate)

…trazodone, warfarin Drugs that may decrease phenytoin serum levels Antineoplastic agents usually in combination Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (etiqueta de Fosfenitoína, Interacciones medicamentosas)

Nitrous Oxide The use of nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, resulting in the potential for increase toxicity. (etiqueta de Metotrexato, Interacciones medicamentosas)

Initiate supplementation with oral folic acid and intramuscular vitamin B 12 to reduce the severity of hematologic and gastrointestinal toxicity of PEMFEXY. (etiqueta de Pemetrexed, Advertencias y precauciones)

Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (etiqueta de Polimixina B y trimetoprima (oftálmica), Precauciones)

Administer vitamin B 12 and instruct patients to take folic acid to reduce the risk of treatment-related myelosuppression [see Dosage and Administration ( 2.1 )]. (etiqueta de Pralatrexato, Advertencias y precauciones)

Estos fármacos antiepilépticos reducen los niveles de folato, y los suplementos de ácido fólico pueden a su vez reducir los niveles en sangre del fármaco. (NIH Office of Dietary Supplements, Folate)

Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (etiqueta de Sapropterina, Interacciones medicamentosas)

Reductions in Vitamins D, E, K (clotting factors) and Folic Acid Levels In preclinical studies in rats and dogs, sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, reduced vitamins D, E, and K (coagulation parameters) and folic acid levels at doses of 6–10 times the recommended human dose. (etiqueta de Sevelámero, Advertencias y precauciones)

Drug Interactions: Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine. (etiqueta de Sulfasalazina, Interacciones medicamentosas)

Serum folate levels may be depressed by oral contraceptive therapy. (etiqueta de Desogestrel y etinilestradiol, Precauciones)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (etiqueta de Dobutamina, Interacciones medicamentosas)

The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. (etiqueta de Hidroxicarbamida (hidroxiurea), Advertencias y precauciones)

In RA, concomitant medications besides MTX were nonsteroidal anti-inflammatory agents (NSAIDs), folic acid, corticosteroids and/or narcotics. (etiqueta de Infliximab, Interacciones medicamentosas)

Interactions with Laboratory Tests Therapeutic concentrations of rifampin have been shown to inhibit standard microbiological assays for serum folate and Vitamin B 12 . (etiqueta de Rifapentina, Interacciones medicamentosas)