Interaksi Fludrokortison

Fludrokortison (Florinef), golongan kortikosteroid, memiliki 374 interaksi terdokumentasi dalam label FDA dan lembar fakta yang kami indeks: 56 mayor, 268 moderat, 50 minor, dan 0 dengan label yang melaporkan tidak ada interaksi bermakna. Setiap entri di bawah ini mengutip kalimat yang mendasarinya. Halaman obat ini adalah titik awal, bukan putusan untuk situasi Anda.

Interaksi dari label

Interaksi mayor (56)

  • AbataseptimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Abirateronpenghambat CYP2D6Mayor

    At the primary analysis, increased incidences of fractures (28.6% vs 11.4%) and deaths (38.5% vs 35.5%) have been observed in patients who received abiraterone acetate plus a corticosteroid in combination with radium Ra 223 dichloride compared to patients who received placebo in combination with abiraterone acetate plus a corticosteroid. (label Abirateron, Peringatan dan perhatian)

  • Abrositinibpenghambat JAKMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • AdalimumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (label Aksitinib, Peringatan dan perhatian)

  • AlemtuzumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Arformoterolagonis beta-adrenergikMayor

    Use of a LABA, including arformoterol tartrate inhalation solution, without an inhaled corticosteroid is contraindicated in patients with asthma. (label Arformoterol, Kontraindikasi)

  • Arsen trioksidaobat yang memperpanjang interval QTMayor

    If differentiation syndrome is suspected, immediately initiate high-dose corticosteroids and hemodynamic monitoring until resolution. (label Arsen trioksida, Peringatan kotak hitam)

  • AtazanavirantiretroviralMayor

    Coadministration of fluticasone propionate and REYATAZ with ritonavir is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects [see Warnings and Precautions (5.1) ] . (label Atazanavir, Interaksi obat)

  • AzatioprinimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Barisitinibpenghambat JAKMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Dimetil fumaratimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Severe hypersensitivity reactions characterized by generalized rash/erythema, hypotension and/or bronchospasm, or fatal anaphylaxis, have been reported in patients premedicated with 3 days of corticosteroids. (label Dosetaksel, Peringatan dan perhatian)

  • …(5.7) , Drug Interactions (7) , and Clinical Pharmacology (12.3) ]: Anticonvulsants: carbamazepine, oxcarbazepine, phenobarbital, phenytoin Antimycobacterials: rifampin, rifapentine Glucocorticoid (systemic): dexamethasone (more than a single-dose) Herbal Products: St John's wort ( Hypericum perforatum ) Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole,… (label Emtrisitabin, rilpivirin, dan tenofovir, Kontraindikasi)

  • EpinefrinsimpatomimetikMayor

    …Antihistamines Thyroid hormones Diuretics Cardiac glycosides, such as digitalis glycosides Quinidine Drugs potentiating hypokalemic effects of epinephrine • Potassium depleting diuretics • Corticosteroids • Theophylline Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines, as a reversal of the pressor effects of epinephrine… (label Epinefrin, Interaksi obat)

  • EtanerseptimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • EverolimusimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • FingolimodimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Formoterolagonis beta-adrenergikMayor

    Use of a LABA, including formoterol fumarate inhalation solution, without an inhaled corticosteroid is contraindicated in patients with asthma [see Warnings and Precautions (5.1) ]. (label Formoterol, Kontraindikasi)

  • FosamprenavirantiretroviralMayor

    Coadministration of fluticasone and fosamprenavir calcium/ritonavir is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. (label Fosamprenavir, Interaksi obat)

  • GuselkumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • InfliksimabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Kandesartanpenghambat reseptor angiotensin II (ARB)Mayor

    Triple combination of candesartan cilexetil with an ACE-inhibitor and a mineralocorticoid receptor antagonist is generally not recommended. (label Kandesartan, Interaksi obat)

  • Ketokonazolantijamur azolMayor

    Fluticasone: Coadministration of fluticasone propionate and ketoconazole is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. (label Ketokonazol, Interaksi obat)

  • KladribinantimetabolitMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • LeflunomidimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • LovastatinstatinMayor

    Moreover, cholesterol and other products of the cholesterol biosynthesis pathway are essential components for fetal development, including synthesis of steroids and cell membranes. (label Lovastatin, Kontraindikasi)

  • MerkaptopurinantimetabolitMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • MetotreksatimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Mifepristonpenghambat CYP3A4Mayor

    WARNING: TERMINATION OF PREGNANCY Mifepristone is a potent antagonist of progesterone and cortisol via the progesterone and glucocorticoid (GR-II) receptors, respectively. (label Mifepriston, Peringatan kotak hitam)

  • MikofenolatimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Mitotanpenginduksi CYP3A4Mayor

    If shock, severe trauma or infection occurs or develops, temporarily discontinue LYSODREN and administer exogenous steroids. (label Mitotan, Peringatan kotak hitam)

  • Moeksiprilpenghambat ACEMayor

    None of the cases were considered life-threatening and all resolved either without treatment or with medication (antihistamines or glucocorticoids). (label Moeksipril, Peringatan)

  • NatalizumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • …2 , Drug Interactions (7.3) ] ) • Immunosuppressants: voclosporin • Microsomal triglyceride transfer protein inhibitor: lomitapide • Migraine medications: eletriptan, ubrogepant • Mineralocorticoid receptor antagonists: finerenone • Non-opioid analgesic (selective blocker of Na v 1.8 sodium channels): suzetrigine • Opioid antagonists: naloxegol • PDE5 inhibitor:… (label Nirmatrelvir dan ritonavir, Kontraindikasi)

  • OkrelizumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Pimekrolimuspenghambat kalsineurinMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • PonesimodimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • RilpivirinantiretroviralMayor

    Antimycobacterials Rifampin Rifapentine Glucocorticoid (systemic) Dexamethasone (more than a single-dose treatment) Herbal Products St. (label Rilpivirin, Kontraindikasi)

  • Ritlesitinibpenghambat JAKMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • RituksimabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Salmeterolagonis beta-adrenergikMayor

    WARNING: ASTHMA-RELATED DEATH Long-acting beta 2 -adrenergic agonists (LABA), such as salmeterol, the active ingredient in SEREVENT DISKUS, as monotherapy (without inhaled corticosteroids [ICS]) increase the risk of asthma-related death. (label Salmeterol, Peringatan kotak hitam)

  • SekukinumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • SiklofosfamidimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • SiklosporinimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • SirolimusimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Intervention: Carefully adjust glucocorticoid dosing in pediatric patients receiving glucocorticoid treatments to avoid both hypoadrenalism and an inhibitory effect on growth. (label Somatropin, Interaksi obat)

  • TakrolimusimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • TeriflunomidimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • TofasitinibimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • TosilizumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • Trandolaprilpenghambat ACEMayor

    Two of the four cases were life-threatening and resolved without treatment or with medication (corticosteroids). (label Trandolapril, Peringatan)

  • TretinoinretinoidMayor

    At first signs or symptoms of this syndrome, immediately initiate high-dose corticosteroid therapy and hemodynamic monitoring until resolution of signs and symptoms. (label Tretinoin, Peringatan kotak hitam)

  • Umeklidinium dan vilanterolantikolinergikMayor

    • use of a long-acting beta 2 -adrenergic agonist (LABA), including vilanterol, one of the active ingredients in Umeclidinium and Vilanterol ELLIPTA, without an inhaled corticosteroid (ICS), in patients with asthma [see Warnings and Precautions ( 5.1 )] . (label Umeklidinium dan vilanterol, Kontraindikasi)

  • UpadasitinibimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

  • UstekinumabimunosupresanMayor

    Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. (label Fludrokortison, Peringatan)

Interaksi moderat (268)

  • AfatinibModerat

    Patients receiving concomitant corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs) or anti-angiogenic agents, or patients with increasing age or who have an underlying history of gastrointestinal ulceration, underlying diverticular disease or bowel metastases may be at increased risk of perforation. (label Afatinib, Peringatan dan perhatian)

  • AkarbosaantidiabetesModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • AklidiniumantikolinergikModerat

    Sympathomimetics, Methylxanthines, Steroids In clinical studies, concurrent administration of aclidinium bromide and other drugs commonly used in the treatment of COPD including sympathomimetics (short-acting beta 2 agonists), methylxanthines, and oral and inhaled steroids showed no increases in adverse drug reactions. (label Aklidinium, Interaksi obat)

  • AlbendazolModerat

    Risk of Neurologic Symptoms: Neurocysticercosis patients may experience cerebral hypertensive episodes, seizures or focal neurologic deficits after initiation of therapy; begin appropriate steroid and anticonvulsant therapy. (label Albendazol, Peringatan dan perhatian)

  • AlendronatbisfosfonatModerat

    …osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (label Alendronat, Peringatan dan perhatian)

  • AliskirenantihipertensiModerat

    Patients who experience these effects, even without respiratory distress, require prolonged observation and appropriate monitoring measures since treatment with antihistamines and corticosteroids may not be sufficient to prevent respiratory involvement. (label Aliskiren, Peringatan dan perhatian)

  • Alogliptinpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Alogliptin dan metforminpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • AlpelisibModerat

    If a SCAR is not confirmed, VIJOICE may require dose modifications, topical or systemic corticosteroids, or oral antihistamine treatment as described in Table 4 [see Dosage and Administration (2.5)] . (label Alpelisib, Peringatan dan perhatian)

  • Amfoterisin BantijamurModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Amiloriddiuretik hemat kaliumModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • ApiksabanantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • ArgatrobanantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Asam etakrinatdiuretik loopModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Asam mefenamatOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, anti-platelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs), smoking, use of alcohol, older age, and poor general health status. (label Asam mefenamat, Peringatan dan perhatian)

  • Asam valproatantikonvulsanModerat

    Oral Contraceptive Steroids Administration of a single-dose of ethinyloestradiol (50 mcg)/levonorgestrel (250 mcg) to 6 women on valproate (200 mg BID) therapy for 2 months did not reveal any pharmacokinetic interaction. (label Asam valproat, Interaksi obat)

  • Asam zoledronatbisfosfonatModerat

    A dental examination with appropriate preventive dentistry should be considered prior to treatment with bisphosphonates in patients with a history of concomitant risk factors (e.g., cancer, chemotherapy, angiogenesis inhibitors, radiotherapy, corticosteroids, poor oral hygiene, preexisting dental disease or infection, anemia, coagulopathy). (label Asam zoledronat, Peringatan dan perhatian)

  • Asetazolamidpenghambat karbonat anhidraseModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • AspirinOAINSModerat

    Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin. (label Fludrokortison, Interaksi obat)

  • Aspirin dan dipiridamolantiplateletModerat

    Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin. (label Fludrokortison, Interaksi obat)

  • Atenolol dan klortalidonpenyekat betaModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • BalsalazidsalisilatModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • BeklometasonkortikosteroidModerat

    Although QVAR REDIHALER may provide control of asthmatic symptoms during these episodes, in recommended doses it supplies less than normal physiological amounts of glucocorticoid systemically and does NOT provide the mineralocorticoid that is necessary for coping with these emergencies. (label Beklometason, Peringatan dan perhatian)

  • Beksagliflozinpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Beladona dan opiumopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Beladona dan opium, Peringatan dan perhatian)

  • Benazepril dan hidroklorotiazidpenghambat ACEModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Consider measures to prevent severe reactions, including antihistamines, antipyretics and corticosteroids in subsequent cycles in patients who have experienced Grade 1 or 2 infusion reactions. (label Bendamustin, Peringatan dan perhatian)

  • • Reduction in Corticosteroid Dosage: Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with FASENRA. (label Benralizumab, Peringatan dan perhatian)

  • BikalutamidandrogenModerat

    Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • Corticosteroids (systemic): cortisone/hydrocortisone dexamethasone ↑ corticosteroids (systemic) ↓ lenacapavir (dexamethasone) Concomitant administration with systemic corticosteroids whose exposures are significantly increased by CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. (label Biktegravir, emtrisitabin, dan tenofovir alafenamid, Interaksi obat)

  • Bismut subsalisilatsalisilatModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • BivalirudinantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • BortezomibModerat

    Management of orthostatic/postural hypotension may include adjustment of antihypertensive medications, hydration, and administration of mineralocorticoids and/or sympathomimetics. (label Bortezomib, Peringatan dan perhatian)

  • BudesonidkortikosteroidModerat

    Although PULMICORT FLEXHALER may provide control of asthma symptoms during these episodes, in recommended doses it supplies less than normal physiological amounts of glucocorticoid systemically and does NOT provide the mineralocorticoid activity that is necessary for coping with these emergencies. (label Budesonid, Peringatan dan perhatian)

  • Budesonid dan formoterolkortikosteroidModerat

    In this situation, the patient requires immediate re-evaluation with reassessment of the treatment regimen, giving special consideration to the possible need for replacing the current strength of budesonide and formoterol fumarate dihydrate with a higher strength, adding additional inhaled corticosteroid, or initiating systemic corticosteroids. (label Budesonid dan formoterol, Peringatan dan perhatian)

  • Bumetaniddiuretik loopModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • BuprenorfinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Buprenorfin, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Buprenorfin dan nalokson, Peringatan dan perhatian)

  • BupropionantidepresanModerat

    …risk of seizure: concomitant use of other medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids), metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia), or use of illicit drugs (e.g., cocaine) or abuse or misuse… (label Bupropion, Peringatan dan perhatian)

  • Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin. (label Fludrokortison, Interaksi obat)

  • Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin. (label Fludrokortison, Interaksi obat)

  • Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • ButorfanolopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Butorfanol, Peringatan)

  • DabigatranantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Dalfampridinsuplemen kaliumModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • DanazolandrogenModerat

    Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • Dapagliflozinpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Dapagliflozin dan metforminpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • DaptomisinantibiotikModerat

    Eosinophilic pneumonia: Discontinue Daptomycin for Injection and consider treatment with systemic steroids. (label Daptomisin, Peringatan dan perhatian)

  • DarunavirantiretroviralModerat

    Corticosteroids: dexamethasone (systemic) ↓ darunavir Co-administration of PREZISTA/ritonavir with systemic dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to darunavir. (label Darunavir, Interaksi obat)

  • Darunavir dan kobisistatantiretroviralModerat

    Corticosteroids: dexamethasone (systemic) Corticosteroids primarily metabolized by CYP3A: e.g. betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↓ darunavir ↓ cobicistat ↑ corticosteroids Co-administration with systemic dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic… (label Darunavir dan kobisistat, Interaksi obat)

  • Deferasirokssuplemen zat besiModerat

    The risk of GI hemorrhage may be increased when administering Exjade in combination with drugs that have ulcerogenic or hemorrhagic potential, such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, oral bisphosphonates, or anticoagulants. (label Deferasiroks, Peringatan dan perhatian)

  • DenosumabModerat

    Other risk factors for the development of ONJ include immunosuppressive therapy, treatment with angiogenesis inhibitors, systemic corticosteroids, diabetes, and gingival infections. (label Denosumab, Peringatan dan perhatian)

  • Desogestrel dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • DiflunisalOAINSModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • Digoksinglikosida digitalisModerat

    Digitalis glycosides — enhanced possibility of arrhythmias or digitalis toxicity associated with hypokalemia. (label Fludrokortison, Interaksi obat)

  • DiklofenakOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Diklofenak, Peringatan dan perhatian)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Diklofenak dan misoprostol, Peringatan dan perhatian)

  • DisikloverinantikolinergikModerat

    Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. (label Disikloverin, Interaksi obat)

  • Drospirenon dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Dulaglutidagonis reseptor GLP-1Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • DupilumabModerat

    Eosinophilic Conditions: Be alert to vasculitic rash, worsening pulmonary symptoms, cardiac complications, kidney injury and/or neuropathy, especially upon reduction of oral corticosteroids. (label Dupilumab, Peringatan dan perhatian)

  • EdoksabanantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Eksenatidagonis reseptor GLP-1Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Although other risk factors were present in some cases (such as corticosteroid use, exposure to radiation), a possible risk attributable to treatment with ivacaftor cannot be excluded. (label Eleksakaftor, tezakaftor, dan ivakaftor, Peringatan dan perhatian)

  • Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone ↓ elvitegravir ↓ cobicistat ↑ corticosteroids Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to elvitegravir. (label Elvitegravir, kobisistat, emtrisitabin, dan tenofovir, Interaksi obat)

  • Empagliflozinpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Empagliflozin dan metforminpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Enalapril dan hidroklorotiazidpenghambat ACEModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • EnoksaparinantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Eplerenonantagonis aldosteronModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • ErlotinibModerat

    Patients receiving concomitant anti-angiogenic agents, corticosteroids, NSAIDs, or taxane-based chemotherapy, or who have prior history of peptic ulceration or diverticular disease may be at increased risk of perforation [see Adverse Reactions (6.1 , 6.2) ]. (label Erlotinib, Peringatan dan perhatian)

  • EstradiolestrogenModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Estradiol dan dienogestkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • Estrogen terkonjugasiestrogenModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • EtodolakOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (label Etodolak, Peringatan)

  • Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • EtravirinantiretroviralModerat

    Corticosteroid : dexamethasone (systemic) ↓ etravirine Systemic dexamethasone induces CYP3A and can decrease etravirine plasma concentrations. (label Etravirin, Interaksi obat)

  • FenilefrindekongestanModerat

    Agonistic Effects (increase in BIORPHEN blood pressure effect) can occur with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids. (label Fenilefrin, Interaksi obat)

  • FenitoinantikonvulsanModerat

    Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • FenobarbitalbarbituratModerat

    Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • FenoprofenOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Fenoprofen, Peringatan dan perhatian)

  • FentanilopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Fentanil, Peringatan dan perhatian)

  • FlunisolidkortikosteroidModerat

    Pregnancy As with other corticosteroids, flunisolide has been shown to be teratogenic and fetotoxic in rabbits and rats at oral doses of 40 and 200 mcg/kg/day, respectively (approximately 2 and 4 times, respectively, the maximum recommended daily intranasal dose in adults on a mg/m 2 basis). (label Flunisolid, Perhatian)

  • FluosinonidkortikosteroidModerat

    Use of more than one corticosteroid-containing product at the same time may increase the total systemic absorption of topical corticosteroids. (label Fluosinonid, Peringatan dan perhatian)

  • FlurbiprofenOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking, use of alcohol, older age, and poor general health status. (label Flurbiprofen, Peringatan dan perhatian)

  • FlutamidandrogenModerat

    Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • FlutikasonkortikosteroidModerat

    Although Fluticasone Propionate DISKUS may control asthma symptoms during these episodes, in recommended doses it supplies less than normal physiological amounts of glucocorticoid systemically and does NOT provide the mineralocorticoid activity that is necessary for coping with these emergencies. (label Flutikason, Peringatan dan perhatian)

  • Flutikason dan salmeterolkortikosteroidModerat

    In this situation, the patient requires immediate reevaluation with reassessment of the treatment regimen, giving special consideration to the possible need for replacing the current strength of Fluticasone Propionate/Salmeterol MDPI with a higher strength, adding additional inhaled corticosteroid, or initiating systemic corticosteroids. (label Flutikason dan salmeterol, Peringatan dan perhatian)

  • FondaparinuksantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • FosfenitoinantikonvulsanModerat

    Other Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D Drugs whose level is decreased by phenytoin Anticoagulants Apixaban, dabigatran, edoxaban, rivaroxaban Antiepileptic drugs The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels… (label Fosfenitoin, Interaksi obat)

  • Fosinopril dan hidroklorotiazidpenghambat ACEModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • FulvestrantestrogenModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Furosemiddiuretik loopModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • GlibenklamidsulfonilureaModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Glibenklamid dan metforminsulfonilureaModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • GlimepiridsulfonilureaModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • GlipizidsulfonilureaModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Glipizid dan metforminsulfonilureaModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (label Gliserol fenilbutirat, Interaksi obat)

  • HalobetasolkortikosteroidModerat

    Use of more than one corticosteroid-containing product at the same time may increase the total systemic exposure to topical corticosteroids. (label Halobetasol, Peringatan dan perhatian)

  • HaloperidolantipsikotikModerat

    Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (label Haloperidol, Interaksi obat)

  • HeparinantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • HidralazinvasodilatorModerat

    Long-term treatment with steroids may be necessary (see PRECAUTIONS, Laboratory Tests ). (label Hidralazin, Peringatan)

  • Hidroklorotiaziddiuretik tiazidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • HidrokodonopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidrokodon, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidrokodon dan homatropin, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidrokodon dan ibuprofen, Peringatan)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidrokodon dan klorfeniramin, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidrokodon dan parasetamol, Peringatan)

  • HidrokortisonkortikosteroidModerat

    Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. (label Fludrokortison, Peringatan)

  • HidromorfonopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Hidromorfon, Peringatan dan perhatian)

  • IbandronatbisfosfonatModerat

    …osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (label Ibandronat, Peringatan dan perhatian)

  • IbuprofenOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Ibuprofen, Peringatan dan perhatian)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Ibuprofen dan famotidin, Peringatan dan perhatian)

  • Imatinibpenghambat CYP3A4Moderat

    If either is abnormal, consider prophylactic use of systemic steroids (1-2 mg/kg) for one to two weeks concomitantly with Gleevec at the initiation of therapy. (label Imatinib, Peringatan dan perhatian)

  • Indapamiddiuretik tiazidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • IndometasinOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Indometasin, Peringatan dan perhatian)

  • Insulin aspartinsulinModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Insulin degludekinsulinModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Insulin detemirinsulinModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Insulin glargininsulinModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Insulin lisproinsulinModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Irbesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Ivakaftorpenghambat CYP3A4Moderat

    Although other risk factors were present in some cases (such as corticosteroid use and/or exposure to radiation), a possible risk attributable to KALYDECO cannot be excluded. (label Ivakaftor, Peringatan dan perhatian)

  • IvermektinModerat

    Oral hydration, recumbency, intravenous normal saline, and/or parenteral corticosteroids have been used to treat postural hypotension. (label Ivermektin, Peringatan)

  • KaliumVitamin dan mineralModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • Kalium kloridasuplemen kaliumModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • Kalium sitratsuplemen kaliumModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • Kanagliflozinpenghambat SGLT2Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Kandesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • KetoprofenOAINSModerat

    PRECAUTIONS General Ketoprofen Capsules, USP cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. (label Ketoprofen, Peringatan dan perhatian)

  • KetorolakOAINSModerat

    In addition to past history of ulcer disease, other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids, or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (label Ketorolak, Peringatan dan perhatian)

  • Klorotiaziddiuretik tiazidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Klortalidondiuretik tiazidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • KodeinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Kodein, Peringatan dan perhatian)

  • Kokainanestetik lokalModerat

    Plasma cholinesterase activity may be decreased by chronic administration of certain monoamine oxidase inhibitors, oral contraceptives, glucocorticoids, antimyasthenics (neostigmine), cyclophosphamide, and possibly thiotepa. (label Kokain, Interaksi obat)

  • Kuinapril dan hidroklorotiazidpenghambat ACEModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • LenakapavirantiretroviralModerat

    Corticosteroids (systemic): cortisone/hydrocortisone dexamethasone ↑ corticosteroids (systemic) Concomitant administration with systemic corticosteroids whose exposures are significantly increased by CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. (label Lenakapavir, Interaksi obat)

  • LevofloksasinfluorokuinolonModerat

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients usually over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (label Levofloksasin, Peringatan dan perhatian)

  • Levonorgestrel dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • LevorfanolopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Levorfanol, Peringatan)

  • Levosalbutamolagonis beta-adrenergikModerat

    If the patient needs more doses of XOPENEX HFA than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (label Levosalbutamol, Peringatan dan perhatian)

  • Levotiroksinhormon tiroidModerat

    Failure to do so may precipitate an acute adrenal crisis when thyroid hormone therapy is initiated, due to increased metabolic clearance of glucocorticoids by thyroid hormone. (label Levotiroksin, Peringatan dan perhatian)

  • Levotiroksin dan liotironinhormon tiroidModerat

    The therapy of myxedema coma requires simultaneous administration of glucocorticoids (See DOSAGE AND ADMINISTRATION). (label Levotiroksin dan liotironin, Perhatian)

  • Linagliptinpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Linagliptin dan metforminpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Liotironinhormon tiroidModerat

    Acute Adrenal Crisis in Patients with Concomitant Adrenal Insufficiency Thyroid hormone increases metabolic clearance of glucocorticoids. (label Liotironin, Peringatan dan perhatian)

  • Liraglutidagonis reseptor GLP-1Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Lisinopril dan hidroklorotiazidpenghambat ACEModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Lopinavir dan ritonavirantiretroviralModerat

    …Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone ↓ lopinavir ↑ glucocorticoids Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to lopinavir. (label Lopinavir dan ritonavir, Interaksi obat)

  • Losartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • In patients who experience mild or moderate IRRs, consider premedications, including antihistamines, corticosteroids, and antipyretics. (label Margetuksimab, Peringatan dan perhatian)

  • MedroksiprogesteronprogestinModerat

    MPA Injectable Suspension, USP can pose an additional risk in patients with risk factors for osteoporosis (e.g., metabolic bone disease, chronic alcohol and/or tobacco use, anorexia nervosa, strong family history of osteoporosis or chronic use of drugs that can reduce bone mass such as anticonvulsants or corticosteroids). (label Medroksiprogesteron, Peringatan dan perhatian)

  • MegestrolprogestinModerat

    Laboratory evaluation for adrenal insufficiency and consideration of replacement or stress doses of a rapidly acting glucocorticoid are strongly recommended in such patients. (label Megestrol, Peringatan dan perhatian)

  • MeloksikamOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Meloksikam, Peringatan dan perhatian)

  • Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • Decrease corticosteroids gradually, if appropriate. (label Mepolizumab, Peringatan dan perhatian)

  • MesalazinsalisilatModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • MetadonopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Metadon, Peringatan dan perhatian)

  • Metazolamidpenghambat karbonat anhidraseModerat

    Drug Interactions Methazolamide should be used with caution in patients on steroid therapy because of the potential for developing hypokalemia. (label Metazolamid, Interaksi obat)

  • MetforminbiguanidModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • MetildopaantihipertensiModerat

    If not, corticosteroids may be given and other causes of anemia should be considered. (label Metildopa, Peringatan)

  • MetiltestosteronandrogenModerat

    Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • MetiraponModerat

    This can be corrected by giving appropriate doses of corticosteroids. (label Metirapon, Peringatan dan perhatian)

  • MetoheksitalbarbituratModerat

    Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • Metolazondiuretik tiazidModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Midodrinagonis alfa-adrenergikModerat

    The potential for supine hypertension should be carefully monitored in these patients and may be minimized by either reducing the dose of fludrocortisone acetate or decreasing the salt intake prior to initiation of treatment with midodrine hydrochloride. (label Midodrin, Interaksi obat)

  • MiglitolantidiabetesModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • MoksifloksasinfluorokuinolonModerat

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (label Moksifloksasin, Peringatan dan perhatian)

  • MometasonkortikosteroidModerat

    Although ASMANEX HFA may improve control of asthma symptoms during these episodes, in recommended doses it supplies less than normal physiological amounts of corticosteroid systemically and does NOT provide the mineralocorticoid activity necessary for coping with these emergencies. (label Mometason, Peringatan dan perhatian)

  • Montelukastantagonis reseptor leukotrienModerat

    Inhaled corticosteroid may be reduced gradually. (label Montelukast, Peringatan dan perhatian)

  • MorfinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Morfin, Peringatan dan perhatian)

  • NabumetonOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (label Nabumeton, Peringatan)

  • NalbufinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Nalbufin, Peringatan)

  • Naltrekson dan bupropionantagonis opioidModerat

    …hypoglycemia concomitant administration of medications that may lower the seizure threshold, including other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, systemic steroids Recommendations for Reducing the Risk of Seizure: Clinical experience with bupropion suggests that the risk of seizure may be minimized by adhering to the recommended… (label Naltrekson dan bupropion, Peringatan dan perhatian)

  • NaproksenOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Naproksen, Peringatan dan perhatian)

  • Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Naproksen dan esomeprazol, Peringatan dan perhatian)

  • NateglinidmeglitinidModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (label Natrium fenilasetat dan natrium benzoat, Interaksi obat)

  • Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (label Natrium fenilbutirat, Interaksi obat)

  • Natrium polistiren sulfonatsuplemen kaliumModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • NintedanibModerat

    Use OFEV with caution when treating patients with recent abdominal surgery, previous history of diverticular disease or receiving concomitant corticosteroids or NSAIDs. (label Nintedanib, Peringatan dan perhatian)

  • Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Noretisteron dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Norgestimat dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • Norgestrel dan etinilestradiolkontrasepsi oralModerat

    Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. (label Fludrokortison, Interaksi obat)

  • OfloksasinfluorokuinolonModerat

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (label Ofloksasin, Peringatan)

  • OksaprozinOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Oksaprozin, Peringatan dan perhatian)

  • OksikodonopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Oksikodon, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Oksikodon dan parasetamol, Peringatan dan perhatian)

  • OksimorfonopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Oksimorfon, Peringatan dan perhatian)

  • OliseridinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Oliseridin, Peringatan dan perhatian)

  • Olmesartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Olmesartan, amlodipin, dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • OmalizumabModerat

    Corticosteroid Reduction: Do not abruptly discontinue corticosteroids upon initiation of OMLYCLO therapy. (label Omalizumab, Peringatan dan perhatian)

  • Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin. (label Fludrokortison, Interaksi obat)

  • PamidronatbisfosfonatModerat

    Many of these patients were also receiving chemotherapy and corticosteroids, which may be risk factors for ONJ. (label Pamidronat, Peringatan dan perhatian)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Parasetamol dan ibuprofen, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Parasetamol dan kodein, Peringatan)

  • PasireotidModerat

    If adrenal insufficiency is suspected, it should be confirmed and treated per standard of care with exogenous glucocorticoids at replacement doses . (label Pasireotid, Peringatan dan perhatian)

  • Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (label Penisilamin, Peringatan)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Pentazosin dan nalokson, Peringatan)

  • PetidinopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Petidin, Peringatan dan perhatian)

  • PioglitazontiazolidindionModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Pioglitazon dan glimepiridtiazolidindionModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Pioglitazon dan metformintiazolidindionModerat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • PiroksikamOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Piroksikam, Peringatan dan perhatian)

  • PrimidonantikonvulsanModerat

    Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Prometazin dan kodein, Peringatan dan perhatian)

  • Propofoldepresan SSPModerat

    The following appear to be major risk factors for the development of these events: decreased oxygen delivery to tissues; serious neurological injury and/or sepsis; high dosages of one or more of the following pharmacological agents: vasoconstrictors, steroids, inotropes and/or prolonged, high-dose infusions of propofol (> 5 mg/kg/hour for > 48 hours). (label Propofol, Peringatan dan perhatian)

  • RepaglinidmeglitinidModerat

    Monitor serum potassium levels; use potassium supplements if necessary. (label Fludrokortison, Interaksi obat)

  • RifampisinantibiotikModerat

    Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. (label Fludrokortison, Interaksi obat)

  • RifapentinantibiotikModerat

    …Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics Sulfonylureas (e.g., glyburide, glipizide) Hormonal Contraceptives/Progestins Ethinyl estradiol, levonorgestrel Immunosuppressants… (label Rifapentin, Interaksi obat)

  • RisedronatbisfosfonatModerat

    …the jaw include invasive dental procedures (for example, tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (for example, chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (for example, periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection,… (label Risedronat, Peringatan dan perhatian)

  • RitonavirantiretroviralModerat

    Systemic/Inhaled/ Nasal/Ophthalmic Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone prednisone triamcinolone ↑ glucocorticoids Coadministration with corticosteroids whose exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.Alternative… (label Ritonavir, Interaksi obat)

  • RivaroksabanantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Rokuroniumpenyekat neuromuskularModerat

    Therefore, for patients receiving both neuromuscular blocking agents (including Rocuronium Bromide Injection) and corticosteroids, the period of use of the neuromuscular blocking agent should be limited as much as possible and only used in the setting where in the opinion of the prescribing physician, the specific advantages of the drug outweigh the risk. (label Rokuronium, Peringatan dan perhatian)

  • Saksagliptinpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Saksagliptin dan metforminpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Salbutamolagonis beta-adrenergikModerat

    If the patient needs more doses of Albuterol Sulfate HFA than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (label Salbutamol, Peringatan dan perhatian)

  • SalsalatOAINSModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • SefoksitinsefalosporinModerat

    High concentrations of cefoxitin in the urine may interfere with measurement of urinary 17-hydroxy-corticosteroids by the Porter-Silber reaction, and produce false increases of modest degree in the levels reported. (label Sefoksitin, Peringatan dan perhatian)

  • SelekoksibOAINSModerat

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Selekoksib, Peringatan dan perhatian)

  • Semaglutidagonis reseptor GLP-1Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • SiklesonidkortikosteroidModerat

    Although ALVESCO may provide control of asthma symptoms during these episodes, in recommended doses it supplies less than normal physiological amounts of corticosteroid systemically and does NOT provide the mineralocorticoid activity that is necessary for coping with these emergencies. (label Siklesonid, Peringatan dan perhatian)

  • SiprofloksasinfluorokuinolonModerat

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (label Siprofloksasin, Peringatan dan perhatian)

  • Sitagliptinpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • Sitagliptin dan metforminpenghambat DPP-4Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • SitarabinantimetabolitModerat

    These reactions include reversible corneal toxicity, and hemorrhagic conjunctivitis, which may be prevented or diminished by prophylaxis with a local corticosteroid eye drop; cerebral and cerebellar dysfunction, including personality changes, somnolence and coma, usually reversible; severe gastrointestinal ulceration, including pneumatosis cystoides intestinalis… (label Sitarabin, Peringatan)

  • Spironolaktonantagonis aldosteronModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Spironolakton dan hidroklorotiazidantagonis aldosteronModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Suksinilkolinpenyekat neuromuskularModerat

    The neuromuscular blocking effect of succinylcholine may be enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives, glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma cholinesterase [see Warnings and Precautions (5.9) ]. (label Suksinilkolin, Interaksi obat)

  • SulfasalazinsulfonamidaModerat

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (label Fludrokortison, Interaksi obat)

  • SulindakOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (label Sulindak, Peringatan)

  • Other factors that increase the risk for gastrointestinal bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (label Sumatriptan dan naproksen, Peringatan dan perhatian)

  • TapentadolopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Tapentadol, Peringatan dan perhatian)

  • Telmisartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Pneumocystis Pneumonia (PCP) : Closely monitor all patients, particularly those receiving steroids, for the development of lymphopenia and PCP. (label Temozolomid, Peringatan dan perhatian)

  • If ILD is suspected, discontinue TORISEL, and consider use of corticosteroids and/or antibiotics. (label Temsirolimus, Peringatan dan perhatian)

  • TeofilinmetilxantinModerat

    Dosage Increases: Increases in the dose of theophylline should not be made in response to an acute exacerbation of symptoms of chronic lung disease since theophylline provides little added benefit to inhaled beta2 -selective agonists and systemically administered corticosteroids in this circumstance and increases the risk of adverse effects. (label Teofilin, Peringatan)

  • Terbutalinagonis beta-adrenergikModerat

    If the patient needs more doses of terbutaline sulfate tablets than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and the treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (label Terbutalin, Peringatan)

  • Teriparatidhormon tiroidModerat

    Risk factors for development of calciphylaxis include underlying auto-immune disease, kidney failure, and concomitant warfarin or systemic corticosteroid use. (label Teriparatid, Peringatan dan perhatian)

  • Glucocorticoids : Patients receiving glucocorticoid replacement for previously diagnosed hypoadrenalism may require an increase in maintenance or stress doses following initiation of EGRIFTA SV. (label Tesamorelin, Interaksi obat)

  • TestosteronandrogenModerat

    Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (label Fludrokortison, Interaksi obat)

  • TiotropiumantikolinergikModerat

    Concomitant Respiratory Medications SPIRIVA RESPIMAT has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, oral and inhaled steroids, antihistamines, mucolytics, leukotriene modifiers, cromones, and anti-IgE treatment without increases in adverse reactions. (label Tiotropium, Interaksi obat)

  • Tirzepatidagonis reseptor GLP-1Moderat

    Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (label Fludrokortison, Interaksi obat)

  • TolmetinOAINSModerat

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (label Tolmetin, Peringatan)

  • Torasemiddiuretik loopModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • TramadolopioidModerat

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Tramadol, Peringatan dan perhatian)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (label Tramadol dan parasetamol, Peringatan dan perhatian)

  • Interrupt TRAZIMERA infusion in all patients experiencing dyspnea, clinically significant hypotension, and intervention of medical therapy administered (which may include epinephrine, corticosteroids, diphenhydramine, bronchodilators, and oxygen). (label Trastuzumab, Peringatan dan perhatian)

  • Triamterendiuretik hemat kaliumModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Triamteren dan hidroklorotiaziddiuretik hemat kaliumModerat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Valsartan dan hidroklorotiazidpenghambat reseptor angiotensin II (ARB)Moderat

    Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (label Fludrokortison, Interaksi obat)

  • Vorikonazolantijamur azolModerat

    • Adrenal Dysfunction : Carefully monitor patients receiving voriconazole and corticosteroids (via all routes of administration) for adrenal dysfunction both during and after voriconazole treatment. (label Vorikonazol, Peringatan dan perhatian)

  • WarfarinantikoagulanModerat

    Oral anticoagulants — decreased prothrombin time response. (label Fludrokortison, Interaksi obat)

  • Prior to the first BIZENGRI infusion, premedicate with a corticosteroid, an H1 antihistamine and acetaminophen to reduce the risk of IRRs [see Dosage and Administration (2.4) ]. (label Zenokutuzumab, Peringatan dan perhatian)

Penyebutan minor (50)

  • If signs of hypersensitivity occur, e.g. anaphylactoid reaction or angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy (e.g., antihistamines, intravenous corticosteroids, epinephrine). (label Alteplase, Peringatan dan perhatian)

  • Amfetaminstimulan SSPMinor

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (label Amfetamin, Interaksi obat)

  • Interference with Laboratory Tests Amphetamines can cause a significant elevation in plasma corticosteroid levels. (label Amfetamin dan dekstroamfetamin, Interaksi obat)

  • AmikasinaminoglikosidaMinor

    Most patients with hypersensitivity pneumonitis discontinued treatment with ARIKAYCE and received treatment with corticosteroids [see Adverse Reactions (6.1) ] . (label Amikasin, Peringatan dan perhatian)

  • AmiodaronantiaritmiaMinor

    Antithyroid drugs, β-adrenergic blockers, temporary corticosteroid therapy may be necessary to treat the symptoms of hyperthyroidism. (label Amiodaron, Peringatan dan perhatian)

  • Ampisilinantibiotik penisilinMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (label Ampisilin, Peringatan)

  • Asam bempedoatpenghambat OATP1B1Minor

    Tendon rupture may occur more frequently in patients over 60 years of age, in those taking corticosteroid or fluoroquinolone drugs, in patients with renal failure, and in patients with previous tendon disorders. (label Asam bempedoat, Peringatan dan perhatian)

  • Benzilpenisilin (penisilin G)antibiotik penisilinMinor

    Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated. (label Benzilpenisilin (penisilin G), Peringatan)

  • Discontinue in patients who develop a severe infusion-related reaction and administer appropriate medical therapy (e.g., epinephrine, corticosteroids, intravenous antihistamines, bronchodilators and/or oxygen). (label Bevasizumab, Peringatan dan perhatian)

  • The administration of corticosteroids has been suggested, but the results have not been impressive or uniformly successful. (label Busulfan, Peringatan)

  • Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (label Dasatinib, Peringatan dan perhatian)

  • Dekstroamfetaminstimulan SSPMinor

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (label Dekstroamfetamin, Interaksi obat)

  • Droperidolantagonis dopaminMinor

    These would include diuretics, laxatives and supraphysiological use of steroid hormones with mineralocorticoid potential. (label Droperidol, Interaksi obat)

  • EfavirenzantiretroviralMinor

    Appropriate antihistamines and/or corticosteroids may improve the tolerability and hasten the resolution of rash. (label Efavirenz, Peringatan dan perhatian)

  • Appropriate antihistamines and/or corticosteroids may improve the tolerability and hasten the resolution of rash. (label Efavirenz, lamivudin, dan tenofovir, Peringatan dan perhatian)

  • Fenoksimetilpenisilin (penisilin V)antibiotik penisilinMinor

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (label Fenoksimetilpenisilin (penisilin V), Peringatan)

  • FludarabinantimetabolitMinor

    Steroids may or may not be effective in controlling these hemolytic episodes. (label Fludarabin, Peringatan dan perhatian)

  • FluoksetinSSRIMinor

    Most patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these reactions were reported to recover completely. (label Fluoksetin, Peringatan dan perhatian)

  • In the reported cases NME resolved with discontinuation of the glucagon, and treatment with corticosteroids was not effective. (label Glukagon, Peringatan dan perhatian)

  • IpratropiumantikolinergikMinor

    ATROVENT HFA has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids commonly used in the treatment of COPD. (label Ipratropium, Interaksi obat)

  • Kalsitriolanalog vitamin DMinor

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (label Kalsitriol, Interaksi obat)

  • Kanabidiol (obat resep)antikonvulsanMinor

    Some subjects in the EPIDIOLEX clinical trials had pruritus, erythema, and angioedema requiring treatment, including corticosteroids and antihistamines. (label Kanabidiol (obat resep), Peringatan dan perhatian)

  • KarbamazepinantikonvulsanMinor

    …clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, felbamate, glucocorticoids, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, methsuxamide, mianserin, midazolam, mirtazapine, nefazodone, olanzapine, oral… (label Karbamazepin, Interaksi obat)

  • KlofarabinantimetabolitMinor

    The use of prophylactic steroids (e.g., 100 mg/m 2 hydrocortisone on Days 1 through 3) may be of benefit in preventing signs or symptoms of SIRS or capillary leak syndrome. (label Klofarabin, Peringatan dan perhatian)

  • Klomifenmodulator reseptor estrogen selektifMinor

    Elevated urinary steroid levels, varying degrees of electrolyte imbalance, hypovolemia, hemoconcentration, and hypoproteinemia may occur. (label Klomifen, Peringatan)

  • The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (label Kortikotropin, Peringatan dan perhatian)

  • KuininantimalariaMinor

    Drug/Laboratory Interactions Quinine may produce an elevated value for urinary 17-ketogenic steroids when the Zimmerman method is used. (label Kuinin, Interaksi obat)

  • Patients with Grade 1 and 2 TFR may also be treated with corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs) and/or narcotic analgesics for management of TFR symptoms. (label Lenalidomid, Peringatan dan perhatian)

  • The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (label Melfalan, Peringatan)

  • Metamfetaminstimulan SSPMinor

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (label Metamfetamin, Interaksi obat)

  • Following concurrent administration of mitoxantrone injection with corticosteroids, no evidence of drug interactions has been observed. (label Mitoksantron, Interaksi obat)

  • Naltreksonantagonis opioidMinor

    Both cases required hospitalization, and resolved after treatment with antibiotics and corticosteroids. (label Naltrekson, Peringatan dan perhatian)

  • Oksasilinantibiotik penisilinMinor

    If an allergic reaction occurs, the drug should be discontinued and the patient should receive supportive treatment, e.g. , artificial maintenance of ventilation, pressor amines, antihistamines, and corticosteroids. (label Oksasilin, Peringatan)

  • Olanzapin dan fluoksetinantipsikotikMinor

    Most patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these reactions were reported to recover completely. (label Olanzapin dan fluoksetin, Peringatan dan perhatian)

  • PrednisolonkortikosteroidMinor

    Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently. (label Prednisolon, Peringatan dan perhatian)

  • PrednisonkortikosteroidMinor

    Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently. (label Prednison, Peringatan dan perhatian)

  • Propiltiourasilobat antitiroidMinor

    In some cases, vasculitis resolved/improved with drug discontinuation; however, more severe cases required treatment with additional measures including corticosteroids, immunosuppressant therapy, and plasmapheresis. (label Propiltiourasil, Peringatan)

  • Raloksifenmodulator reseptor estrogen selektifMinor

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (label Raloksifen, Interaksi obat)

  • SefadroksilsefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Sefadroksil, Peringatan dan perhatian)

  • SefaklorsefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Sefaklor, Peringatan)

  • SefdinirsefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Sefdinir, Peringatan)

  • SefotetansefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Sefotetan, Peringatan)

  • SefprozilsefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Sefprozil, Peringatan)

  • SeftazidimsefalosporinMinor

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, IV FLUIDS, IV ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (label Seftazidim, Peringatan)

  • SeftriaksonsefalosporinMinor

    Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures including oxygen, corticosteroids, intravenous fluids, intravenous antihistamines, pressor amines, and airway management, as clinically indicated. (label Seftriakson, Peringatan dan perhatian)

  • If symptoms of hypersensitivity occur, initiate appropriate therapy (e.g., antihistamines, corticosteroids, epinephrine). (label Tenekteplase, Peringatan dan perhatian)

  • Tiamazolobat antitiroidMinor

    In some cases, vasculitis resolved/improved with drug discontinuation; however, more severe cases required treatment with additional measures including corticosteroids, immunosuppressant therapy, and plasmapheresis. (label Tiamazol, Peringatan)

  • TobramisinaminoglikosidaMinor

    In clinical studies, patients receiving TOBI Podhaler continued to take dornase alfa, bronchodilators, inhaled corticosteroids, and macrolides. (label Tobramisin, Interaksi obat)

  • Vitamin DVitamin dan mineralMinor

    Kortikosteroid seperti prednison mengurangi penyerapan kalsium dan mengganggu metabolisme vitamin D, sehingga ikut menyebabkan pengeroposan tulang. (NIH Office of Dietary Supplements, Vitamin D)

  • ZiprasidonantipsikotikMinor

    Most patients improved promptly with adjunctive treatment with antihistamines or steroids and/or upon discontinuation of ziprasidone, and all patients experiencing these reactions were reported to recover completely. (label Ziprasidon, Peringatan dan perhatian)

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