Cenobamate and Clopidogrel interaction
Cenobamate and Clopidogrel: the Clopidogrel prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Clopidogrel (Plavix) label · effective 2025-05-30
CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole.
The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole.
CYP2C19 Inhibitors Clopidogrel is metabolized to its active metabolite in part by CYP2C19.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.