Levonorgestrel and ethinyl estradiol and St. John's wort interaction
Levonorgestrel and ethinyl estradiol and St. John's wort: NIH and FDA consumer guidance flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Major
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
Curated guidance for St. John's wort
Major
St. John's wort can make birth control pills less effective.
Curated ruleNCCIH, St. John's Wort
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.