Metoprolol + hydrochlorotiazyd: interakcje

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic. (etykieta leku Amiloryd, Ostrzeżenie w ramce)

Lotensin HCT is also contraindicated in patients who are hypersensitive to benazepril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs. (etykieta leku Benazepryl + hydrochlorotiazyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. (etykieta leku Bumetanid, Ostrzeżenie w ramce)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include patients with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (etykieta leku Chinapryl, Ostrzeżenia)

Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (etykieta leku Choriogonadotropina alfa, Ostrzeżenia)

Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (etykieta leku Cyklosporyna, Interakcje z innymi lekami)

The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (etykieta leku Cytrynian potasu, Interakcje z innymi lekami)

…concomitantly with Ferric Citrate Tablets Amlodipine Aspirin Atorvastatin Calcitriol Clopidogrel Digoxin Diltiazem Doxercalciferol Enalapril Fluvastatin Glimepiride Levofloxacin Losartan Metoprolol Pravastatin Propranolol Sitagliptin Warfarin Oral drugs that have to be separated from Ferric Citrate Tablets and meals Dosing Recommendations Doxycycline Take at least 1… (etykieta leku Cytrynian żelaza(III), Interakcje z innymi lekami)

CONTRAINDICATIONS PROGLYCEM is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides (etykieta leku Diazoksyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

The concomitant use of hydrochlorothiazide (alone or in combinations such as with triamterene) with dofetilide is contraindicated (see PRECAUTIONS, Drug-Drug Interactions ) because this has been shown to significantly increase dofetilide plasma concentrations and QT interval prolongation. (etykieta leku Dofetylid, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (etykieta leku Droperydol, Ostrzeżenie w ramce)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (etykieta leku Enalaprylat, Ostrzeżenia)

…• serum creatinine > 2.0 mg/dL in males or >1.8 mg/dL in females, • creatinine clearance < 50 mL/min, or • concomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1) , Adverse Reactions (6.2) , Drug Interactions (7) , and Clinical Pharmacology (12.3)… (etykieta leku Eplerenon, Przeciwwskazania)

…of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (etykieta leku Eptyfibatyd, Przeciwwskazania)

Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication. (etykieta leku Flekainid, Ostrzeżenie w ramce)

Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (etykieta leku Folitropina, Ostrzeżenia i środki ostrożności)

The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (etykieta leku Gentamycyna, Ostrzeżenie w ramce)

Avoid diuretics or laxatives in patients with diarrhea. (etykieta leku Irynotekan, Ostrzeżenia i środki ostrożności)

Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (etykieta leku Itrakonazol, Interakcje z innymi lekami)

Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (etykieta leku Klozapina, Ostrzeżenie w ramce)

CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (etykieta leku Kwas etakrynowy, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (etykieta leku Metolazon, Ostrzeżenia)

In addition, life-threatening arrhythmias may occur during anesthesia and surgery, and may require treatment with a beta-blocker or lidocaine. (etykieta leku Metyrozyna, Ostrzeżenia)

Minoxidil should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents. (etykieta leku Minoksydyl, Ostrzeżenie w ramce)

Hypotensive Agents Do not use BYSTOLIC with other β-blockers. (etykieta leku Nebiwolol, Interakcje z innymi lekami)

The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (etykieta leku Neomycyna, Ostrzeżenie w ramce)

Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (etykieta leku Protamina, Ostrzeżenie w ramce)

Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg ( 7 ) (etykieta leku Repaglinid, Interakcje z innymi lekami)

Concomitant use with metoclopramide, beta-blockers, or cholinomimetic and anticholinergic drugs is not recommended ( 7.1 , 7.2 , 7.3 ) (etykieta leku Rywastygmina, Interakcje z innymi lekami)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

…coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (etykieta leku Tadalafil, Ostrzeżenia i środki ostrożności)

…Syndrome (SS) c ] Agents with blood pressure-reducing effects Use with caution d Hypotension e Non-selective H1 receptor antagonists Contraindicated a Increased anticholinergic effects Beta-adrenergic blockers (see also agents or procedures with blood pressure-reducing effects) Use with the caution d More pronounced bradycardia, postural hypotension e Blood glucose-lowering… (etykieta leku Tranylcypromina, Interakcje z innymi lekami)

The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (etykieta leku Trójtlenek arsenu, Ostrzeżenia i środki ostrożności)

Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (etykieta leku Wodorowęglan sodu, Przeciwwskazania)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (etykieta leku Metoprolol + hydrochlorotiazyd, Przeciwwskazania)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Although β-blockers should be avoided in overt cardiac failure, acebutolol can be used with caution in patients with a history of heart failure who are controlled with digitalis and/or diuretics. (etykieta leku Acebutolol, Ostrzeżenia)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (etykieta leku Alfuzosyna, Ostrzeżenia i środki ostrożności)

Risk factors for the development of hyperkalemia include renal insufficiency, diabetes, combination use with ARBs or ACEIs [see Contraindications ( 4 ), Warnings and Precautions ( 5.2 ), and Clinical Studies ( 14.3 )] , NSAIDs, or potassium supplements or potassium sparing diuretics. (etykieta leku Aliskiren, Ostrzeżenia i środki ostrożności)

Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (etykieta leku Allopurynol, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). (etykieta leku Amfepramon (dietylopropion), Interakcje z innymi lekami)

Ethacrynic Acid, Furosemide, Urea, or Mannitol Some diuretics can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. (etykieta leku Amikacyna, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

There was also a slightly greater proportion of patients on NUVIGIL requiring new or increased use of antihypertensive medications (2.9%) compared to patients on placebo (1.8%). (etykieta leku Armodafinil, Ostrzeżenia i środki ostrożności)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (etykieta leku Arypiprazol, Interakcje z innymi lekami)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etykieta leku Asenapina, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 selectivity, however, TENORMIN may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Atenolol, Ostrzeżenia)

Because of its relative beta 1 -selectivity, however, atenolol and chlorthalidone may be used with caution in patients with bronchospastic disease who do not respond to or cannot tolerate, other antihypertensive treatment. (etykieta leku Atenolol + chlortalidon, Ostrzeżenia)

Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (etykieta leku Atomoksetyna, Interakcje z innymi lekami)

• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (etykieta leku Awanafil, Ostrzeżenia i środki ostrożności)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with azilsartan medoxomil. (etykieta leku Azylsartan, Ostrzeżenia i środki ostrożności)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mm Hg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (etykieta leku Benazepryl, Ostrzeżenia i środki ostrożności)

Amphetamines may decrease the hypotensive effect of antihypertensives. (etykieta leku Benzfetamina, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because of its relative beta 1 -selectivity, however, BISOPROLOL FUMARATE may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (etykieta leku Bisoprolol, Ostrzeżenia)

Because of the relative beta 1 -selectivity of bisoprolol fumarate, bisoprolol fumarate and hydrochlorothiazide tablets may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (etykieta leku Bisoprolol + hydrochlorotiazyd, Ostrzeżenia)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (etykieta leku Bortezomib, Ostrzeżenia i środki ostrożności)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Brekspiprazol, Ostrzeżenia i środki ostrożności)

Central Nervous System (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs. (etykieta leku Bromfeniramina + pseudoefedryna + dekstrometorfan, Interakcje z innymi lekami)

Use caution in patients taking antihypertensive medications. (etykieta leku Bromokryptyna, Ostrzeżenia i środki ostrożności)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (etykieta leku Brymonidyna, Interakcje z innymi lekami)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (etykieta leku Brymonidyna + tymolol, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Risk of Hypertension and Bradycardia Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Nonselective Beta-Adrenergic Antagonists Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving nonselective beta-adrenergic antagonists may cause severe hypertension and bradycardia. (etykieta leku Bupiwakaina, Ostrzeżenia i środki ostrożności)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Buprenorfina, Interakcje z innymi lekami)

Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Buprenorfina + nalokson, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Butalbital + paracetamol + kofeina + kodeina, Interakcje z innymi lekami)

Diuretics: Nephrotoxicity has been reported with concomitant administration of cephalosporins with potent diuretics such as furosemide. (etykieta leku Cefepim, Interakcje z innymi lekami)

Drug Interactions Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. (etykieta leku Ceftazydym, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

DRUG INTERACTIONS Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances. (etykieta leku Cewimelina, Interakcje z innymi lekami)

The thiazide component of quinapril and hydrochlorothiazide tablets may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic- blocking drugs. (etykieta leku Chinapryl + hydrochlorotiazyd, Ostrzeżenia)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Although clinical drug interaction studies have not been performed, antimalarial doses (greater than or equal to 600 mg) of quinine may inhibit the metabolism of other drugs that are CYP2D6 substrates (e.g., flecainide, debrisoquine, dextromethorphan, metoprolol, paroxetine ). (etykieta leku Chinina, Interakcje z innymi lekami)

Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (etykieta leku Chlorek wapnia, Interakcje z innymi lekami)

Thiazides may add to or potentiate the action of other antihypertensive drugs. (etykieta leku Chlorotiazyd, Ostrzeżenia)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Chlorpromazyna, Środki ostrożności)

Effect of chlorthalidone on other drugs Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. (etykieta leku Chlortalidon, Interakcje z innymi lekami)

…concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (etykieta leku Cyklobenzapryna, Interakcje z innymi lekami)

…inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity… (etykieta leku Cyklofosfamid, Interakcje z innymi lekami)

Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (etykieta leku Cyklokrzemian sodowo-cyrkonowy, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Cytalopram, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Dekslanzoprazol, Ostrzeżenia i środki ostrożności)

• Antihypertensive Drugs: Monitor blood pressure. (etykieta leku Deksmetylofenidat, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

…Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (etykieta leku Desmopresyna, Interakcje z innymi lekami)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (etykieta leku Deswenlafaksyna, Ostrzeżenia i środki ostrożności)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (etykieta leku Dezypramina, Ostrzeżenia)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Beta Blockers Although the results of a clinical study did not indicate a safety problem associated with the administration of Dihydroergotamine Mesylate Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine. (etykieta leku Dihydroergotamina, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (etykieta leku Dokserkalcyferol, Ostrzeżenia i środki ostrożności)

Give a low dose of beta-blockers initially, and increase only after ECG verification of good tolerability [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] . (etykieta leku Dronedaron, Interakcje z innymi lekami)

Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (etykieta leku Drospirenon + etynyloestradiol, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (etykieta leku Enalapryl, Ostrzeżenia i środki ostrożności)

Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (etykieta leku Epoetyna alfa, Ostrzeżenia i środki ostrożności)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (etykieta leku Epoprostenol, Interakcje z innymi lekami)

The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of ergotamine tartrate and caffeine tablets by blocking the vasodilating property of epinephrine. (etykieta leku Ergotamina + kofeina, Interakcje z innymi lekami)

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (etykieta leku Escytalopram, Ostrzeżenia i środki ostrożności)

Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (etykieta leku Esmolol, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Ezomeprazol, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

…treatment with Class 1 and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval and 6) electrolyte imbalance, in particular hypokalemia and hypomagnesemia, or concomitant treatment with drugs (e.g., diuretics) that may cause electrolyte imbalance. (etykieta leku Fentanyl, Ostrzeżenia i środki ostrożności)

Concomitant administration of hydrochlorothiazide alone with topiramate alone has been shown to increase the C max and AUC of topiramate by 27% and 29%, respectively. (etykieta leku Fentermina + topiramat, Interakcje z innymi lekami)

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (etykieta leku Fludrokortyzon, Interakcje z innymi lekami)

Hydrochlorothiazide In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%. (etykieta leku Flukonazol, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Propranolol or metoprolol : Reduce dose if coadministered and titrate more cautiously ( 7.3 ). (etykieta leku Fluwoksamina, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (etykieta leku Foskarnet, Interakcje z innymi lekami)

In separate single or multiple dose pharmacokinetic interaction studies with chlorthalidone, nifedipine, propranolol, hydrochlorothiazide, cimetidine, metoclopramide, propantheline, digoxin, and warfarin, the bioavailability of fosinoprilat was not altered by coadministration of fosinopril with any one of these drugs. (etykieta leku Fozynopryl, Interakcje z innymi lekami)

The thiazide component of fosinopril sodium and hydrochlorothiazide may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic-blocking drugs. (etykieta leku Fozynopryl + hydrochlorotiazyd, Ostrzeżenia)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Table 4: Clinically Significant Drug Interaction with GVOKE and GVOKE VialDx Beta-Blockers Clincial Impact: Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given GVOKE or GVOKE VialDx. (etykieta leku Glukagon, Interakcje z innymi lekami)

Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (etykieta leku Haloperydol, Interakcje z innymi lekami)

Example: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Hydrokodon, Interakcje z innymi lekami)

Diuretics : Hydrocodone may reduce the efficacy of diuretics. (etykieta leku Hydrokodon + chlorfenamina, Interakcje z innymi lekami)

Diuretics : Hydrocodone may reduce the efficacy of diuretics. (etykieta leku Hydrokodon + homatropina, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Hydrokodon + paracetamol, Interakcje z innymi lekami)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Hydromorfon, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Iloperydon, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (etykieta leku Imipramina, Ostrzeżenia)

Drug Interactions Other Antihypertensives: Indapamide may add to or potentiate the action of other antihypertensive drugs. (etykieta leku Indapamid, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Hypotension in Volume or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initialization of treatment with AVAPRO. (etykieta leku Irbesartan, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

The risk of bradycardia increases with concomitant administration of drugs that slow heart rate (e.g., digoxin, amiodarone, beta-blockers). (etykieta leku Iwabradyna, Interakcje z innymi lekami)

Concomitant Use with Beta Blockers Concomitant use of beta blockers may exaggerate the cardiovascular effects of inhalational anesthetics, including hypotension and negative inotropic effects. (etykieta leku Izofluran, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (etykieta leku Jodek potasu, Interakcje z innymi lekami)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (etykieta leku Kalcytriol, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (etykieta leku Kandesartan, Ostrzeżenia i środki ostrożności)

Hypotension Excessive hypotension was rarely seen in hypertensive patients but is a possible consequence of captopril use in salt/volume depleted persons (such as those treated vigorously with diuretics), patients with heart failure or those patients undergoing renal dialysis (see PRECAUTIONS : Drug Interactions ). (etykieta leku Kaptopryl, Ostrzeżenia)

Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (etykieta leku Karbamazepina, Ostrzeżenia i środki ostrożności)

Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (etykieta leku Karbidopa, Interakcje z innymi lekami)

Antihypertensive drugs: May cause symptomatic postural hypotension. (etykieta leku Karbidopa + lewodopa, Interakcje z innymi lekami)

Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (etykieta leku Karbidopa + lewodopa + entakapon, Interakcje z innymi lekami)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (etykieta leku Kariprazyna, Ostrzeżenia i środki ostrożności)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (etykieta leku Karwedilol, Ostrzeżenia i środki ostrożności)

Antivirals indinavir, maraviroc, saquinavir Beta Blockers nadolol Calcium Channel Blockers felodipine, nisoldipine other dihydropyridines, verapamil Calcium channel blockers can have a negative inotropic effect which may be additive to those of ketoconazole. (etykieta leku Ketokonazol, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Consider use of diuretics and/or albumin. (etykieta leku Klofarabina, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Kodeina, Interakcje z innymi lekami)

Cholestyramine and colestipol: Reduced absorption of thiazides. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Cholestyramine and colestipol: Reduced absorption of thiazides. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (etykieta leku Kwas zoledronowy, Ostrzeżenia i środki ostrożności)

Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (etykieta leku Kwetiapina, Ostrzeżenia i środki ostrożności)

VIMPAT should also be used with caution in patients on concomitant medications that affect cardiac conduction, including sodium channel blockers, beta-blockers, calcium channel blockers, potassium channel blockers, and medications that prolong the PR interval [see Drug Interactions (7.2) ] . (etykieta leku Lakozamid, Ostrzeżenia i środki ostrożności)

Bradycardia-Inducing Drugs (e.g., beta-blockers) : Lanreotide Injection may decrease heart rate. (etykieta leku Lanreotyd, Interakcje z innymi lekami)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (etykieta leku Lanzoprazol, Ostrzeżenia i środki ostrożności)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease, may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (etykieta leku Ledipaswir + sofosbuwir, Ostrzeżenia i środki ostrożności)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (etykieta leku Lewomilnacypran, Ostrzeżenia i środki ostrożności)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Leworfanol, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Drug or Drug Class Effect Beta-adrenergic antagonists e.g., Propranolol > 160 mg/day) In patients treated with large doses of propranolol (> 160 mg/day), T 3 and T 4 levels change slightly, TSH levels remain normal, and patients are clinically euthyroid. (etykieta leku Lewotyroksyna, Interakcje z innymi lekami)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Drug or Drug Class Effect Beta-adrenergic antagonists (e.g., Propranolol >160 mg/day) In patients treated with large doses of propranolol (>160 mg/day), T3 and T4 levels change, TSH levels remain normal, and patients are clinically euthyroid. (etykieta leku Liotyronina, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Lithium: Risk of lithium toxicity. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (etykieta leku Lizynopryl, Ostrzeżenia i środki ostrożności)

When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (see DOSAGE AND ADMINISTRATION ). (etykieta leku Lizynopryl + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with COZAAR. (etykieta leku Losartan, Ostrzeżenia i środki ostrożności)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (etykieta leku Lumateperon, Ostrzeżenia i środki ostrożności)

Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (etykieta leku Lurazydon, Ostrzeżenia i środki ostrożności)

There is one report of cardiopulmonary arrest, with full recovery, in a patient who was taking a beta blocker (propranolol) (see PRECAUTIONS, Cardiac Effects ). (etykieta leku Meflochina, Interakcje z innymi lekami)

The action of Mecamylamine HCl may be potentiated by anesthesia, other antihypertensive drugs and alcohol. (etykieta leku Mekamylamina, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Closely monitor patients with risk factors for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia), a history of cardiac conduction abnormalities, and those taking medications affecting cardiac conduction. (etykieta leku Metadon, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Metoprolol Tartrate Tablets [see Dosage and Administration (2) ]. (etykieta leku Metoprolol, Ostrzeżenia i środki ostrożności)

Beta-blockers Caution should be exercised when methylergonovine maleate is used concurrently with beta-blockers. (etykieta leku Metyloergometryna, Interakcje z innymi lekami)

Antihypertensive Drugs: Monitor blood pressure. (etykieta leku Metylofenidat, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (etykieta leku Milnacypran, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (etykieta leku Mirtazapina, Ostrzeżenia i środki ostrożności)

However, a retrospective analysis of the use of antihypertensive medication in these studies showed that a greater proportion of patients on PROVIGIL required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). (etykieta leku Modafinil, Ostrzeżenia i środki ostrożności)

Symptomatic hypotension is most likely to occur in patients who have been salt- and volume- depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (etykieta leku Moeksypryl, Ostrzeżenia)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Morfina, Interakcje z innymi lekami)

Patients receiving concomitant negative chronotropic drugs (e.g., beta blockers) may be more at risk for hypotension in case of hypersensitivity reaction. (etykieta leku Motixafortide, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, they can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (etykieta leku Nadolol, Ostrzeżenia)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Nalbufina, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (etykieta leku Niacyna (kwas nikotynowy), Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antihypertensives: Possible additive hypotensive effects. (etykieta leku Nitrogliceryna, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Oksykodon, Interakcje z innymi lekami)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Oksykodon + paracetamol, Interakcje z innymi lekami)

Caution in using drugs such as beta-blockers, anti-hypertensives, and/or cardiac glycosides is advised. (etykieta leku Oksymetazolina, Interakcje z innymi lekami)

Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Oksymorfon, Interakcje z innymi lekami)

Dosage adjustments of concomitantly used drugs that have bradycardia effects (i.e. beta-blockers) may be necessary [see Drug Interactions (‎7.2) ]. (etykieta leku Oktreotyd, Ostrzeżenia i środki ostrożności)

…of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (etykieta leku Olanzapina, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Olicerydyna, Interakcje z innymi lekami)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin-aldosterone system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may be anticipated after initiation of treatment with Benicar. (etykieta leku Olmesartan, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (etykieta leku Omeprazol, Ostrzeżenia i środki ostrożności)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (etykieta leku Omeprazol + wodorowęglan sodu, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (etykieta leku Paliperydon, Ostrzeżenia i środki ostrożności)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (etykieta leku Pantoprazol, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Paracetamol + kodeina, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (etykieta leku Parykalcytol, Ostrzeżenia i środki ostrożności)

Adjustments in the dose of drugs known to slow the heart rate (e.g., beta-blockers, calcium channel blockers) and correction of electrolyte disturbances may be necessary when initiating or during the course of SIGNIFOR LAR treatment. (etykieta leku Pasyreotyd, Ostrzeżenia i środki ostrożności)

Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (etykieta leku Pazopanib, Ostrzeżenia i środki ostrożności)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Pentazocyna + nalokson, Interakcje z innymi lekami)

Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (etykieta leku Pentoksyfilina, Interakcje z innymi lekami)

Symptomatic hypotension is most likely to occur in patients who have been volume or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea or vomiting [see Dosage and Administration (2.1) ] . (etykieta leku Peryndopryl, Ostrzeżenia i środki ostrożności)

Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Petydyna, Interakcje z innymi lekami)

Drug Interactions Pilocarpine should be administered with caution to patients taking beta-adrenergic antagonists because of the possibility of conduction disturbances. (etykieta leku Pilokarpina, Interakcje z innymi lekami)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, pindolol tablets can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (etykieta leku Pindolol, Ostrzeżenia)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Use with caution in persons with increased risk of anticholinergic reactions, such as persons with bronchial asthma, chronic obstructive pulmonary disease, bradycardia, cardiac arrhythmias, beta blocker treatment (increased risk of anticholinergic reactions). (etykieta leku Pirydostygmina, Ostrzeżenia i środki ostrożności)

Diuretics Clinical Impact : Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Pokrzyk wilcza jagoda (belladonna) + opium, Interakcje z innymi lekami)

Experience with PONVORY is limited in patients receiving concurrent therapy with drugs that decrease heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers - diltiazem and verapamil, and other drugs that may decrease heart rate such as digoxin). (etykieta leku Ponesimod, Ostrzeżenia i środki ostrożności)

Syncopal episodes have usually occurred within 30 to 90 minutes of the initial dose of the drug; occasionally, they have been reported in association with rapid dosage increases or the introduction of another antihypertensive drug into the regimen of a patient taking high doses of prazosin hydrochloride capsules. (etykieta leku Prazosyna, Ostrzeżenia)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Prochlorperazyna, Środki ostrożności)

Diuretics : Codeine may reduce the efficacy of diuretics. (etykieta leku Prometazyna + kodeina, Interakcje z innymi lekami)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Beta-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (etykieta leku Propylotiouracyl, Interakcje z innymi lekami)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (etykieta leku Rabeprazol, Ostrzeżenia i środki ostrożności)

Experience with another ACE inhibitor suggests that these increases would be reversible upon discontinuation of ramipril and/or diuretic therapy. (etykieta leku Ramipryl, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (etykieta leku Riocyguat, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Patients on beta-blockers may not manifest changes in heart rate, but blood pressure monitoring can detect a rise in systolic blood pressure. (etykieta leku Ropiwakaina, Ostrzeżenia i środki ostrożności)

Decrease exposure Beta-blockers Metoprolol Decrease exposure Propranolol Decrease exposure Benzodiazepines Diazepam , Administered with rifampin 1200 mg daily Decrease exposure Benzodiazepine-related drugs Zopiclone Decrease AUC by 82% Zolpidem Decrease AUC by 73% Calcium Channel Blockers Diltiazem Decrease exposure Nifedipine Rifampin 1200 mg administered as… (etykieta leku Ryfampicyna, Interakcje z innymi lekami)

…Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics… (etykieta leku Ryfapentyna, Interakcje z innymi lekami)

Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (etykieta leku Rysperydon, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Nadolol/Metoprolol : In a drug interactions study, effects of multiple doses of nadolol 80 mg or metoprolol 100 mg every 12 hours on the pharmacokinetics of a single dose of 10 mg rizatriptan were evaluated in healthy subjects (n=12). (etykieta leku Ryzatryptan, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), are at greater risk. (etykieta leku Sakubitryl + walsartan, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Sertralina, Ostrzeżenia i środki ostrożności)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (etykieta leku Sofosbuwir + welpataswir, Ostrzeżenia i środki ostrożności)

Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (etykieta leku Sorafenib, Ostrzeżenia i środki ostrożności)

Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (etykieta leku Sotalol, Ostrzeżenia i środki ostrożności)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (etykieta leku Suksametonium, Ostrzeżenia i środki ostrożności)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Initiate and/or adjust antihypertensive therapy as appropriate. (etykieta leku Sunitynib, Ostrzeżenia i środki ostrożności)

Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (etykieta leku Syldenafil, Ostrzeżenia i środki ostrożności)

However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (etykieta leku Sylodosyna, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

• Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (etykieta leku Takrolimus, Ostrzeżenia i środki ostrożności)

…use of skeletal muscle relaxants and opioids, consider prescribing naloxone for the emergency treatment of opioid overdose [see Dosage and Administration (2.2) , Warnings and Precautions (5.2 , 5.3) ] Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Tapentadol, Interakcje z innymi lekami)

Beta-adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. (etykieta leku Tasimelteon, Interakcje z innymi lekami)

Hypotension In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of therapy with telmisartan tablets. (etykieta leku Telmisartan, Ostrzeżenia i środki ostrożności)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Risk of Hypotension with Concomitant Use of Other Antihypertensive Agents and Phospodiesterase Type 5 Inhibitors (PDE5-I): Concomitant administration of TEZRULY with antihypertensives or phosphodiesterase-5 (PDE-5) inhibitors can result in additive blood pressure lowering effects and symptomatic hypotension (5.3). (etykieta leku Terazosyna, Ostrzeżenia i środki ostrożności)

CYP2D6 inhibitors: Increased metoprolol concentration. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (etykieta leku Testosteron, Ostrzeżenia i środki ostrożności)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

…(oral): Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. β-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (etykieta leku Tiamazol, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. (etykieta leku Tobramycyna, Interakcje z innymi lekami)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (etykieta leku Tolwaptan, Ostrzeżenia i środki ostrożności)

Hydrochlorothiazide (HCTZ) Topiramate C max and AUC increased when HCTZ was added to immediate-release topiramate. (etykieta leku Topiramat, Interakcje z innymi lekami)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (etykieta leku Toremifen, Interakcje z innymi lekami)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Tramadol, Interakcje z innymi lekami)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (etykieta leku Tramadol + paracetamol, Interakcje z innymi lekami)

Symptomatic hypotension is most likely to occur in patients who have been salt- or volume-depleted as a result of prolonged treatment with diuretics, dietary salt restriction, dialysis, diarrhea, or vomiting. (etykieta leku Trandolapryl, Ostrzeżenia)

Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (etykieta leku Trazodon, Ostrzeżenia i środki ostrożności)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (etykieta leku Trifluoperazyna, Środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. (etykieta leku Walsartan, Ostrzeżenia i środki ostrożności)

Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (etykieta leku Wardenafil, Interakcje z innymi lekami)

Caution should be exercised with co-administration of venlafaxine and metoprolol. (etykieta leku Wenlafaksyna, Interakcje z innymi lekami)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (etykieta leku Wilazodon, Ostrzeżenia i środki ostrożności)

Diuretyki tiazydowe zmniejszają wydalanie wapnia; w połączeniu z suplementami witaminy D i wapnia może to prowadzić do hiperkalcemii, zwłaszcza u osób starszych. (NIH Office of Dietary Supplements, Vitamin D)

Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (etykieta leku Wortioksetyna, Ostrzeżenia i środki ostrożności)

Zileuton increases propranolol levels and beta-blocker activity. (etykieta leku Zileuton, Interakcje z innymi lekami)

Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (etykieta leku Zyprazydon, Ostrzeżenia i środki ostrożności)

Effects of Adenosine on Other Drugs Adenosine injection has been given with other cardioactive drugs (such as beta adrenergic blocking agents, cardiac glycosides, and calcium channel blockers) without apparent adverse interactions, but its effectiveness with these agents has not been systematically evaluated. (etykieta leku Adenozyna, Interakcje z innymi lekami)

Coadministration of 1 Dyazide (triamterene/hydrochlorothiazide) resulted in a higher plasma amantadine hydrochloride concentration in a 61-year old man receiving amantadine hydrochloride 100 mg TID for Parkinson's disease. (etykieta leku Amantadyna, Interakcje z innymi lekami)

Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (etykieta leku Ambrisentan, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (etykieta leku Bosentan, Ostrzeżenia i środki ostrożności)

In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive drugs. (etykieta leku Butorfanol, Ostrzeżenia)

Diuretyki tiazydowe przy długotrwałym stosowaniu zwiększają utratę cynku z moczem. (NIH Office of Dietary Supplements, Zinc)

Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (etykieta leku Dazatynib, Ostrzeżenia i środki ostrożności)

Examples of alkalinizing agents include gastrointestinal alkalinizing agents (e.g., sodium bicarbonate) and urinary alkalinizing agents (e.g. acetazolamide, some thiazides). (etykieta leku Deksamfetamina, Interakcje z innymi lekami)

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (etykieta leku Dezogestrel + etynyloestradiol, Ostrzeżenia)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (etykieta leku Docetaksel, Ostrzeżenia i środki ostrożności)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Examples: α-adrenergic antagonists, β-adrenergic receptor antagonists, reserpine, quinidine, mephentermine Other Drug Interactions G u anethidine C linical Impact: Ephedrine may inhibit the neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. (etykieta leku Efedryna, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

In addition to discontinuation of the drug, diuretic therapy may be required. (etykieta leku Estrogeny estryfikowane + metylotestosteron, Ostrzeżenia)

In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, ULORIC does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ]. (etykieta leku Febuksostat, Interakcje z innymi lekami)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

…PROSCAR was concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines,… (etykieta leku Finasteryd, Interakcje z innymi lekami)

Drugs That Slow Heart Rate or Atrioventricular Conduction (e.g., beta blockers or diltiazem) Experience with GILENYA in patients receiving concurrent therapy with drugs that slow the heart rate or AV conduction (e.g., beta blockers, digoxin, or heart rate-slowing calcium channel blockers, such as diltiazem or verapamil) is limited. (etykieta leku Fingolimod, Interakcje z innymi lekami)

Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (etykieta leku Glukonian wapnia, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (etykieta leku Ikatybant, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (etykieta leku Kortykotropina, Interakcje z innymi lekami)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (etykieta leku Macytentan, Ostrzeżenia i środki ostrożności)

Długotrwałe stosowanie diuretyków pętlowych i tiazydowych zwiększa utratę magnezu z moczem. (NIH Office of Dietary Supplements, Magnesium)

In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (etykieta leku Meksyletyna, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Amphotericin B injection and potassium-depleting agents : When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. (etykieta leku Metyloprednizolon, Interakcje z innymi lekami)

In addition to discontinuation of the drug, diuretic therapy may be required. (etykieta leku Metylotestosteron, Ostrzeżenia)

…been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements. (etykieta leku Milrinon, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

The antihypertensive action of guanethidine and similar agents may be blocked. (etykieta leku Nortryptylina, Ostrzeżenia)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Drug Interactions Metabolism of a number of medications, including antipsychotics, antidepressants, β-blockers, and antiarrhythmics, occurs through the cytochrome P450 2D6 isoenzyme (debrisoquine hydroxylase). (etykieta leku Perfenazyna, Interakcje z innymi lekami)

Diuretyki pętlowe i tiazydowe zwiększają utratę potasu; niekiedy razem z nimi przepisuje się suplementację. (NIH Office of Dietary Supplements, Potassium)

Potassium-depleting agents (e.g., diuretics, Amphotericin B): When corticosteroids are administered concomitantly with potassium-depleting agents, patients should be observed closely for development of hypokalemia. (etykieta leku Prednizolon, Interakcje z innymi lekami)

Potassium-Depleting Agents (e.g., Diuretics, Amphotericin B) When corticosteroids are administered concomitantly with potassium-depleting agents, patients should be observed closely for development of hypokalemia. (etykieta leku Prednizon, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (etykieta leku Protryptylina, Ostrzeżenia)

Pheochromocytoma: First initiate therapy with an alpha blocker. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents ( i.e., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. (etykieta leku Triamcynolon, Interakcje z innymi lekami)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (etykieta leku Metoprolol + hydrochlorotiazyd, Ostrzeżenia i środki ostrożności)

Diuretyki tiazydowe zmniejszają wydalanie wapnia, więc duże spożycie wapnia może podnosić stężenie wapnia we krwi. (NIH Office of Dietary Supplements, Calcium)

Beta-adrenergic blocking agents: Coadministration of beta-adrenergic blocking agents did not have any effect on either the safety or efficacy of ibutilide in the clinical trials. (etykieta leku Ibutylid, Interakcje z innymi lekami)

Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (etykieta leku Kwas pamidronowy, Interakcje z innymi lekami)

Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (etykieta leku Ropinirol, Interakcje z innymi lekami)

Table 5: Sevelamer Drug Interactions Oral drugs for which sevelamer did not alter the pharmacokinetics when administered concomitantly Digoxin Enalapril Iron Metoprolol Warfarin Oral drugs that have demonstrated interaction with sevelamer and are to be dosed separately from sevelamer carbonate Dosing Recommendations Ciprofloxacin Take at least 2 hours before… (etykieta leku Sewelamer, Interakcje z innymi lekami)