Interações de Metoprolol + hidroclorotiazida

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (bula de Ácido etacrínico, Contraindicações)

Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (bula de Alfacoriogonadotropina, Advertências)

Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic. (bula de Amilorida, Advertência em caixa preta)

Lotensin HCT is also contraindicated in patients who are hypersensitive to benazepril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs. (bula de Benazepril + hidroclorotiazida, Contraindicações)

Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (bula de Bicarbonato de sódio, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. (bula de Bumetanida, Advertência em caixa preta)

Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (bula de Ciclosporina, Interações medicamentosas)

The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (bula de Citrato de potássio, Interações medicamentosas)

…concomitantly with Ferric Citrate Tablets Amlodipine Aspirin Atorvastatin Calcitriol Clopidogrel Digoxin Diltiazem Doxercalciferol Enalapril Fluvastatin Glimepiride Levofloxacin Losartan Metoprolol Pravastatin Propranolol Sitagliptin Warfarin Oral drugs that have to be separated from Ferric Citrate Tablets and meals Dosing Recommendations Doxycycline Take at least 1… (bula de Citrato férrico, Interações medicamentosas)

Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (bula de Clozapina, Advertência em caixa preta)

CONTRAINDICATIONS PROGLYCEM is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides (bula de Diazóxido, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

The concomitant use of hydrochlorothiazide (alone or in combinations such as with triamterene) with dofetilide is contraindicated (see PRECAUTIONS, Drug-Drug Interactions ) because this has been shown to significantly increase dofetilide plasma concentrations and QT interval prolongation. (bula de Dofetilida, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (bula de Droperidol, Advertência em caixa preta)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (bula de Enalaprilate, Advertências)

…• serum creatinine > 2.0 mg/dL in males or >1.8 mg/dL in females, • creatinine clearance < 50 mL/min, or • concomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1) , Adverse Reactions (6.2) , Drug Interactions (7) , and Clinical Pharmacology (12.3)… (bula de Eplerenona, Contraindicações)

…of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (bula de Eptifibatida, Contraindicações)

Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication. (bula de Flecainida, Advertência em caixa preta)

Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (bula de Folitropina, Advertências e precauções)

The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (bula de Gentamicina, Advertência em caixa preta)

Avoid diuretics or laxatives in patients with diarrhea. (bula de Irinotecano, Advertências e precauções)

Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (bula de Itraconazol, Interações medicamentosas)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

In addition, life-threatening arrhythmias may occur during anesthesia and surgery, and may require treatment with a beta-blocker or lidocaine. (bula de Metirosina, Advertências)

Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (bula de Metolazona, Advertências)

Minoxidil should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents. (bula de Minoxidil, Advertência em caixa preta)

Hypotensive Agents Do not use BYSTOLIC with other β-blockers. (bula de Nebivolol, Interações medicamentosas)

The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (bula de Neomicina, Advertência em caixa preta)

Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION ), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). (bula de Protamina, Advertência em caixa preta)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include patients with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (bula de Quinapril, Advertências)

Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg ( 7 ) (bula de Repaglinida, Interações medicamentosas)

Concomitant use with metoclopramide, beta-blockers, or cholinomimetic and anticholinergic drugs is not recommended ( 7.1 , 7.2 , 7.3 ) (bula de Rivastigmina, Interações medicamentosas)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

…coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (bula de Tadalafila, Advertências e precauções)

…Syndrome (SS) c ] Agents with blood pressure-reducing effects Use with caution d Hypotension e Non-selective H1 receptor antagonists Contraindicated a Increased anticholinergic effects Beta-adrenergic blockers (see also agents or procedures with blood pressure-reducing effects) Use with the caution d More pronounced bradycardia, postural hypotension e Blood glucose-lowering… (bula de Tranilcipromina, Interações medicamentosas)

The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (bula de Trióxido de arsênio, Advertências e precauções)

Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (bula de Metoprolol + hidroclorotiazida, Contraindicações)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Although β-blockers should be avoided in overt cardiac failure, acebutolol can be used with caution in patients with a history of heart failure who are controlled with digitalis and/or diuretics. (bula de Acebutolol, Advertências)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (bula de Ácido zoledrônico, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (bula de Alfaepoetina, Advertências e precauções)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (bula de Alfuzosina, Advertências e precauções)

Risk factors for the development of hyperkalemia include renal insufficiency, diabetes, combination use with ARBs or ACEIs [see Contraindications ( 4 ), Warnings and Precautions ( 5.2 ), and Clinical Studies ( 14.3 )] , NSAIDs, or potassium supplements or potassium sparing diuretics. (bula de Alisquireno, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (bula de Alopurinol, Advertências e precauções)

Ethacrynic Acid, Furosemide, Urea, or Mannitol Some diuretics can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. (bula de Amicacina, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). (bula de Anfepramona (dietilpropiona), Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (bula de Aripiprazol, Interações medicamentosas)

There was also a slightly greater proportion of patients on NUVIGIL requiring new or increased use of antihypertensive medications (2.9%) compared to patients on placebo (1.8%). (bula de Armodafinila, Advertências e precauções)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (bula de Asenapina, Advertências e precauções)

Because of its relative beta 1 selectivity, however, TENORMIN may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Atenolol, Advertências)

Because of its relative beta 1 -selectivity, however, atenolol and chlorthalidone may be used with caution in patients with bronchospastic disease who do not respond to or cannot tolerate, other antihypertensive treatment. (bula de Atenolol + clortalidona, Advertências)

Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (bula de Atomoxetina, Interações medicamentosas)

• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (bula de Avanafila, Advertências e precauções)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with azilsartan medoxomil. (bula de Azilsartana, Advertências e precauções)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Diuretics Clinical Impact : Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Beladona + ópio, Interações medicamentosas)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mm Hg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (bula de Benazepril, Advertências e precauções)

Amphetamines may decrease the hypotensive effect of antihypertensives. (bula de Benzfetamina, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because of its relative beta 1 -selectivity, however, BISOPROLOL FUMARATE may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (bula de Bisoprolol, Advertências)

Because of the relative beta 1 -selectivity of bisoprolol fumarate, bisoprolol fumarate and hydrochlorothiazide tablets may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (bula de Bisoprolol + hidroclorotiazida, Advertências)

Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (bula de Bortezomibe, Advertências e precauções)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Brexpiprazol, Advertências e precauções)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (bula de Brimonidina, Interações medicamentosas)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (bula de Brimonidina + timolol, Interações medicamentosas)

Use caution in patients taking antihypertensive medications. (bula de Bromocriptina, Advertências e precauções)

Central Nervous System (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs. (bula de Bronfeniramina + pseudoefedrina + dextrometorfano, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Risk of Hypertension and Bradycardia Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Nonselective Beta-Adrenergic Antagonists Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving nonselective beta-adrenergic antagonists may cause severe hypertension and bradycardia. (bula de Bupivacaína, Advertências e precauções)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Buprenorfina, Interações medicamentosas)

Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Buprenorfina + naloxona, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Butalbital + paracetamol + cafeína + codeína, Interações medicamentosas)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (bula de Calcitriol, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (bula de Candesartana, Advertências e precauções)

Hypotension Excessive hypotension was rarely seen in hypertensive patients but is a possible consequence of captopril use in salt/volume depleted persons (such as those treated vigorously with diuretics), patients with heart failure or those patients undergoing renal dialysis (see PRECAUTIONS : Drug Interactions ). (bula de Captopril, Advertências)

Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (bula de Carbamazepina, Advertências e precauções)

Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (bula de Carbidopa, Interações medicamentosas)

Antihypertensive drugs: May cause symptomatic postural hypotension. (bula de Carbidopa + levodopa, Interações medicamentosas)

Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (bula de Carbidopa + levodopa + entacapona, Interações medicamentosas)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Cariprazina, Advertências e precauções)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (bula de Carvedilol, Advertências e precauções)

Diuretics: Nephrotoxicity has been reported with concomitant administration of cephalosporins with potent diuretics such as furosemide. (bula de Cefepima, Interações medicamentosas)

Drug Interactions Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. (bula de Ceftazidima, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antivirals indinavir, maraviroc, saquinavir Beta Blockers nadolol Calcium Channel Blockers felodipine, nisoldipine other dihydropyridines, verapamil Calcium channel blockers can have a negative inotropic effect which may be additive to those of ketoconazole. (bula de Cetoconazol, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

DRUG INTERACTIONS Cevimeline should be administered with caution to patients taking beta adrenergic antagonists, because of the possibility of conduction disturbances. (bula de Cevimelina, Interações medicamentosas)

…concomitant use of TONMYA with: MAO inhibitors may be life-threatening [see Contraindications (4) ] , Alcohol, barbiturates, and other CNS depressants may increase the risk of adverse reactions associated with these drugs, Tramadol may increase the seizure risk, Guanethidine or other similar acting drugs may block the antihypertensive action of these drugs. (bula de Ciclobenzaprina, Interações medicamentosas)

…inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity… (bula de Ciclofosfamida, Interações medicamentosas)

Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (bula de Ciclossilicato de zircônio sódico, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Citalopram, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Consider use of diuretics and/or albumin. (bula de Clofarabina, Advertências e precauções)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (bula de Cloreto de cálcio, Interações medicamentosas)

Thiazides may add to or potentiate the action of other antihypertensive drugs. (bula de Clorotiazida, Advertências)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Clorpromazina, Precauções)

Effect of chlorthalidone on other drugs Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. (bula de Clortalidona, Interações medicamentosas)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Codeína, Interações medicamentosas)

Cholestyramine and colestipol: Reduced absorption of thiazides. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Cholestyramine and colestipol: Reduced absorption of thiazides. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (bula de Desipramina, Advertências)

…Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (bula de Desmopressina, Interações medicamentosas)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (bula de Desvenlafaxina, Advertências e precauções)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Dexlansoprazol, Advertências e precauções)

• Antihypertensive Drugs: Monitor blood pressure. (bula de Dexmetilfenidato, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Beta Blockers Although the results of a clinical study did not indicate a safety problem associated with the administration of Dihydroergotamine Mesylate Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine. (bula de Di-hidroergotamina, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (bula de Doxercalciferol, Advertências e precauções)

Give a low dose of beta-blockers initially, and increase only after ECG verification of good tolerability [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] . (bula de Dronedarona, Interações medicamentosas)

Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (bula de Drospirenona + etinilestradiol, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (bula de Enalapril, Advertências e precauções)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (bula de Epoprostenol, Interações medicamentosas)

The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of ergotamine tartrate and caffeine tablets by blocking the vasodilating property of epinephrine. (bula de Ergotamina + cafeína, Interações medicamentosas)

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (bula de Escitalopram, Advertências e precauções)

Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (bula de Esmolol, Interações medicamentosas)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Esomeprazol, Advertências e precauções)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

…treatment with Class 1 and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval and 6) electrolyte imbalance, in particular hypokalemia and hypomagnesemia, or concomitant treatment with drugs (e.g., diuretics) that may cause electrolyte imbalance. (bula de Fentanila, Advertências e precauções)

Concomitant administration of hydrochlorothiazide alone with topiramate alone has been shown to increase the C max and AUC of topiramate by 27% and 29%, respectively. (bula de Fentermina + topiramato, Interações medicamentosas)

Hydrochlorothiazide In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%. (bula de Fluconazol, Interações medicamentosas)

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (bula de Fludrocortisona, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Propranolol or metoprolol : Reduce dose if coadministered and titrate more cautiously ( 7.3 ). (bula de Fluvoxamina, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (bula de Foscarnete, Interações medicamentosas)

In separate single or multiple dose pharmacokinetic interaction studies with chlorthalidone, nifedipine, propranolol, hydrochlorothiazide, cimetidine, metoclopramide, propantheline, digoxin, and warfarin, the bioavailability of fosinoprilat was not altered by coadministration of fosinopril with any one of these drugs. (bula de Fosinopril, Interações medicamentosas)

The thiazide component of fosinopril sodium and hydrochlorothiazide may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic-blocking drugs. (bula de Fosinopril + hidroclorotiazida, Advertências)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Table 4: Clinically Significant Drug Interaction with GVOKE and GVOKE VialDx Beta-Blockers Clincial Impact: Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given GVOKE or GVOKE VialDx. (bula de Glucagon, Interações medicamentosas)

Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (bula de Haloperidol, Interações medicamentosas)

Example: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Hidrocodona, Interações medicamentosas)

Diuretics : Hydrocodone may reduce the efficacy of diuretics. (bula de Hidrocodona + clorfeniramina, Interações medicamentosas)

Diuretics : Hydrocodone may reduce the efficacy of diuretics. (bula de Hidrocodona + homatropina, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Hidrocodona + paracetamol, Interações medicamentosas)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Hidromorfona, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (bula de Iloperidona, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (bula de Imipramina, Advertências)

Drug Interactions Other Antihypertensives: Indapamide may add to or potentiate the action of other antihypertensive drugs. (bula de Indapamida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (bula de Iodeto de potássio, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Hypotension in Volume or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initialization of treatment with AVAPRO. (bula de Irbesartana, Advertências e precauções)

Concomitant Use with Beta Blockers Concomitant use of beta blockers may exaggerate the cardiovascular effects of inhalational anesthetics, including hypotension and negative inotropic effects. (bula de Isoflurano, Interações medicamentosas)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

The risk of bradycardia increases with concomitant administration of drugs that slow heart rate (e.g., digoxin, amiodarone, beta-blockers). (bula de Ivabradina, Interações medicamentosas)

VIMPAT should also be used with caution in patients on concomitant medications that affect cardiac conduction, including sodium channel blockers, beta-blockers, calcium channel blockers, potassium channel blockers, and medications that prolong the PR interval [see Drug Interactions (7.2) ] . (bula de Lacosamida, Advertências e precauções)

Bradycardia-Inducing Drugs (e.g., beta-blockers) : Lanreotide Injection may decrease heart rate. (bula de Lanreotida, Interações medicamentosas)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (bula de Lansoprazol, Advertências e precauções)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease, may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (bula de Ledipasvir + sofosbuvir, Advertências e precauções)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (bula de Levomilnaciprana, Advertências e precauções)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Levorfanol, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Drug or Drug Class Effect Beta-adrenergic antagonists e.g., Propranolol > 160 mg/day) In patients treated with large doses of propranolol (> 160 mg/day), T 3 and T 4 levels change slightly, TSH levels remain normal, and patients are clinically euthyroid. (bula de Levotiroxina, Interações medicamentosas)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Drug or Drug Class Effect Beta-adrenergic antagonists (e.g., Propranolol >160 mg/day) In patients treated with large doses of propranolol (>160 mg/day), T3 and T4 levels change, TSH levels remain normal, and patients are clinically euthyroid. (bula de Liotironina, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (bula de Lisinopril, Advertências e precauções)

When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (see DOSAGE AND ADMINISTRATION ). (bula de Lisinopril + hidroclorotiazida, Interações medicamentosas)

Lithium: Risk of lithium toxicity. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with COZAAR. (bula de Losartana, Advertências e precauções)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (bula de Lumateperona, Advertências e precauções)

Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (bula de Lurasidona, Advertências e precauções)

The action of Mecamylamine HCl may be potentiated by anesthesia, other antihypertensive drugs and alcohol. (bula de Mecamilamina, Interações medicamentosas)

There is one report of cardiopulmonary arrest, with full recovery, in a patient who was taking a beta blocker (propranolol) (see PRECAUTIONS, Cardiac Effects ). (bula de Mefloquina, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Closely monitor patients with risk factors for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia), a history of cardiac conduction abnormalities, and those taking medications affecting cardiac conduction. (bula de Metadona, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Beta-blockers Caution should be exercised when methylergonovine maleate is used concurrently with beta-blockers. (bula de Metilergometrina, Interações medicamentosas)

Antihypertensive Drugs: Monitor blood pressure. (bula de Metilfenidato, Interações medicamentosas)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Metoprolol Tartrate Tablets [see Dosage and Administration (2) ]. (bula de Metoprolol, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (bula de Milnaciprana, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (bula de Mirtazapina, Advertências e precauções)

However, a retrospective analysis of the use of antihypertensive medication in these studies showed that a greater proportion of patients on PROVIGIL required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). (bula de Modafinila, Advertências e precauções)

Symptomatic hypotension is most likely to occur in patients who have been salt- and volume- depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (bula de Moexipril, Advertências)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Morfina, Interações medicamentosas)

Patients receiving concomitant negative chronotropic drugs (e.g., beta blockers) may be more at risk for hypotension in case of hypersensitivity reaction. (bula de Motixafortida, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, they can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (bula de Nadolol, Advertências)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Nalbufina, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (bula de Niacina (ácido nicotínico), Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antihypertensives: Possible additive hypotensive effects. (bula de Nitroglicerina, Interações medicamentosas)

Dosage adjustments of concomitantly used drugs that have bradycardia effects (i.e. beta-blockers) may be necessary [see Drug Interactions (‎7.2) ]. (bula de Octreotida, Advertências e precauções)

…of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (bula de Olanzapina, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Oliceridina, Interações medicamentosas)

Hypotension in Volume- or Salt-Depleted Patients In patients with an activated renin-angiotensin-aldosterone system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may be anticipated after initiation of treatment with Benicar. (bula de Olmesartana, Advertências e precauções)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (bula de Omeprazol, Advertências e precauções)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (bula de Omeprazol + bicarbonato de sódio, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Oxicodona, Interações medicamentosas)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Oxicodona + paracetamol, Interações medicamentosas)

Caution in using drugs such as beta-blockers, anti-hypertensives, and/or cardiac glycosides is advised. (bula de Oximetazolina, Interações medicamentosas)

Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Oximorfona, Interações medicamentosas)

Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (bula de Paliperidona, Advertências e precauções)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (bula de Pantoprazol, Advertências e precauções)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Paracetamol + codeína, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (bula de Paricalcitol, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Adjustments in the dose of drugs known to slow the heart rate (e.g., beta-blockers, calcium channel blockers) and correction of electrolyte disturbances may be necessary when initiating or during the course of SIGNIFOR LAR treatment. (bula de Pasireotida, Advertências e precauções)

Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (bula de Pazopanibe, Advertências e precauções)

Diuretics Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Pentazocina + naloxona, Interações medicamentosas)

Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (bula de Pentoxifilina, Interações medicamentosas)

Symptomatic hypotension is most likely to occur in patients who have been volume or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea or vomiting [see Dosage and Administration (2.1) ] . (bula de Perindopril, Advertências e precauções)

Examples: Cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Petidina (meperidina), Interações medicamentosas)

Drug Interactions Pilocarpine should be administered with caution to patients taking beta-adrenergic antagonists because of the possibility of conduction disturbances. (bula de Pilocarpina, Interações medicamentosas)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, pindolol tablets can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (bula de Pindolol, Advertências)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Use with caution in persons with increased risk of anticholinergic reactions, such as persons with bronchial asthma, chronic obstructive pulmonary disease, bradycardia, cardiac arrhythmias, beta blocker treatment (increased risk of anticholinergic reactions). (bula de Piridostigmina, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Experience with PONVORY is limited in patients receiving concurrent therapy with drugs that decrease heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers - diltiazem and verapamil, and other drugs that may decrease heart rate such as digoxin). (bula de Ponesimode, Advertências e precauções)

Syncopal episodes have usually occurred within 30 to 90 minutes of the initial dose of the drug; occasionally, they have been reported in association with rapid dosage increases or the introduction of another antihypertensive drug into the regimen of a patient taking high doses of prazosin hydrochloride capsules. (bula de Prazosina, Advertências)

Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Proclorperazina, Precauções)

Diuretics : Codeine may reduce the efficacy of diuretics. (bula de Prometazina + codeína, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Beta-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (bula de Propiltiouracila, Interações medicamentosas)

Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (bula de Quetiapina, Advertências e precauções)

The thiazide component of quinapril and hydrochlorothiazide tablets may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic- blocking drugs. (bula de Quinapril + hidroclorotiazida, Advertências)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Although clinical drug interaction studies have not been performed, antimalarial doses (greater than or equal to 600 mg) of quinine may inhibit the metabolism of other drugs that are CYP2D6 substrates (e.g., flecainide, debrisoquine, dextromethorphan, metoprolol, paroxetine ). (bula de Quinina, Interações medicamentosas)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (bula de Rabeprazol, Advertências e precauções)

Experience with another ACE inhibitor suggests that these increases would be reversible upon discontinuation of ramipril and/or diuretic therapy. (bula de Ramipril, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Decrease exposure Beta-blockers Metoprolol Decrease exposure Propranolol Decrease exposure Benzodiazepines Diazepam , Administered with rifampin 1200 mg daily Decrease exposure Benzodiazepine-related drugs Zopiclone Decrease AUC by 82% Zolpidem Decrease AUC by 73% Calcium Channel Blockers Diltiazem Decrease exposure Nifedipine Rifampin 1200 mg administered as… (bula de Rifampicina, Interações medicamentosas)

…Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics… (bula de Rifapentina, Interações medicamentosas)

Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (bula de Riociguate, Advertências e precauções)

Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (bula de Risperidona, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Nadolol/Metoprolol : In a drug interactions study, effects of multiple doses of nadolol 80 mg or metoprolol 100 mg every 12 hours on the pharmacokinetics of a single dose of 10 mg rizatriptan were evaluated in healthy subjects (n=12). (bula de Rizatriptana, Interações medicamentosas)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Patients on beta-blockers may not manifest changes in heart rate, but blood pressure monitoring can detect a rise in systolic blood pressure. (bula de Ropivacaína, Advertências e precauções)

Patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients (e.g., those being treated with high doses of diuretics), are at greater risk. (bula de Sacubitril + valsartana, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (bula de Sildenafila, Advertências e precauções)

However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (bula de Silodosina, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Patients also taking beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease may be at increased risk for symptomatic bradycardia with coadministration of amiodarone. (bula de Sofosbuvir + velpatasvir, Advertências e precauções)

Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (bula de Sorafenibe, Advertências e precauções)

Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (bula de Sotalol, Advertências e precauções)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Initiate and/or adjust antihypertensive therapy as appropriate. (bula de Sunitinibe, Advertências e precauções)

Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (bula de Suxametônio (succinilcolina), Advertências e precauções)

• Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (bula de Tacrolimo, Advertências e precauções)

…use of skeletal muscle relaxants and opioids, consider prescribing naloxone for the emergency treatment of opioid overdose [see Dosage and Administration (2.2) , Warnings and Precautions (5.2 , 5.3) ] Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Tapentadol, Interações medicamentosas)

Beta-adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. (bula de Tasimelteona, Interações medicamentosas)

Hypotension In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of therapy with telmisartan tablets. (bula de Telmisartana, Advertências e precauções)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Risk of Hypotension with Concomitant Use of Other Antihypertensive Agents and Phospodiesterase Type 5 Inhibitors (PDE5-I): Concomitant administration of TEZRULY with antihypertensives or phosphodiesterase-5 (PDE-5) inhibitors can result in additive blood pressure lowering effects and symptomatic hypotension (5.3). (bula de Terazosina, Advertências e precauções)

CYP2D6 inhibitors: Increased metoprolol concentration. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (bula de Testosterona, Advertências e precauções)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

…(oral): Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. β-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. (bula de Tiamazol (metimazol), Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Antidiabetic drugs: Dosage adjustment may be required. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. (bula de Tobramicina, Interações medicamentosas)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (bula de Tolvaptana, Advertências e precauções)

Hydrochlorothiazide (HCTZ) Topiramate C max and AUC increased when HCTZ was added to immediate-release topiramate. (bula de Topiramato, Interações medicamentosas)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (bula de Toremifeno, Interações medicamentosas)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Tramadol, Interações medicamentosas)

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. (bula de Tramadol + paracetamol, Interações medicamentosas)

Symptomatic hypotension is most likely to occur in patients who have been salt- or volume-depleted as a result of prolonged treatment with diuretics, dietary salt restriction, dialysis, diarrhea, or vomiting. (bula de Trandolapril, Advertências)

Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (bula de Trazodona, Advertências e precauções)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (bula de Trifluoperazina, Precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The concomitant use of catecholamine-depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) with beta adrenergic blockers may have an additive affect and increase the risk of hypotension or bradycardia CYP2D6 Inhibitors: Drugs that are strong inhibitors of CYP2D6 such as quinidine,… (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. (bula de Valsartana, Advertências e precauções)

Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (bula de Vardenafila, Interações medicamentosas)

Caution should be exercised with co-administration of venlafaxine and metoprolol. (bula de Venlafaxina, Interações medicamentosas)

Digitalis, Clonidine, and Calcium Channel Blockers: Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. (bula de Metoprolol + hidroclorotiazida, Interações medicamentosas)

Because beta1-selectivity is not absolute, use the lowest possible dose of metoprolol tartrate and have bronchodilators (e.g., beta 2 -agonists) readily available or administered concomitantly . (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (bula de Vilazodona, Advertências e precauções)

Os diuréticos tiazídicos reduzem a excreção de cálcio; combinado com suplementos de vitamina D e de cálcio, isso pode levar a hipercalcemia, especialmente em idosos. (NIH Office of Dietary Supplements, Vitamin D)

Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (bula de Vortioxetina, Advertências e precauções)

Zileuton increases propranolol levels and beta-blocker activity. (bula de Zileutona, Interações medicamentosas)

Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (bula de Ziprasidona, Advertências e precauções)

Effects of Adenosine on Other Drugs Adenosine injection has been given with other cardioactive drugs (such as beta adrenergic blocking agents, cardiac glycosides, and calcium channel blockers) without apparent adverse interactions, but its effectiveness with these agents has not been systematically evaluated. (bula de Adenosina, Interações medicamentosas)

Coadministration of 1 Dyazide (triamterene/hydrochlorothiazide) resulted in a higher plasma amantadine hydrochloride concentration in a 61-year old man receiving amantadine hydrochloride 100 mg TID for Parkinson's disease. (bula de Amantadina, Interações medicamentosas)

Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (bula de Ambrisentana, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (bula de Bosentana, Advertências e precauções)

In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive drugs. (bula de Butorfanol, Advertências)

Os diuréticos tiazídicos reduzem a excreção de cálcio, de modo que um consumo alto de cálcio pode elevar o cálcio no sangue. (NIH Office of Dietary Supplements, Calcium)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (bula de Corticotropina, Interações medicamentosas)

Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (bula de Dasatinibe, Advertências e precauções)

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (bula de Desogestrel + etinilestradiol, Advertências)

Examples of alkalinizing agents include gastrointestinal alkalinizing agents (e.g., sodium bicarbonate) and urinary alkalinizing agents (e.g. acetazolamide, some thiazides). (bula de Dextroanfetamina, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (bula de Docetaxel, Advertências e precauções)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Examples: α-adrenergic antagonists, β-adrenergic receptor antagonists, reserpine, quinidine, mephentermine Other Drug Interactions G u anethidine C linical Impact: Ephedrine may inhibit the neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. (bula de Efedrina, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

In addition to discontinuation of the drug, diuretic therapy may be required. (bula de Estrogênios esterificados + metiltestosterona, Advertências)

In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, ULORIC does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ]. (bula de Febuxostate, Interações medicamentosas)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

…PROSCAR was concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines,… (bula de Finasterida, Interações medicamentosas)

Drugs That Slow Heart Rate or Atrioventricular Conduction (e.g., beta blockers or diltiazem) Experience with GILENYA in patients receiving concurrent therapy with drugs that slow the heart rate or AV conduction (e.g., beta blockers, digoxin, or heart rate-slowing calcium channel blockers, such as diltiazem or verapamil) is limited. (bula de Fingolimode, Interações medicamentosas)

Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (bula de Gliconato de cálcio, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (bula de Icatibanto, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (bula de Macitentana, Advertências e precauções)

O uso prolongado de diuréticos de alça e tiazídicos aumenta a perda de magnésio na urina. (NIH Office of Dietary Supplements, Magnesium)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Amphotericin B injection and potassium-depleting agents : When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. (bula de Metilprednisolona, Interações medicamentosas)

In addition to discontinuation of the drug, diuretic therapy may be required. (bula de Metiltestosterona, Advertências)

In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (bula de Mexiletina, Interações medicamentosas)

…been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements. (bula de Milrinona, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

The antihypertensive action of guanethidine and similar agents may be blocked. (bula de Nortriptilina, Advertências)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Drug Interactions Metabolism of a number of medications, including antipsychotics, antidepressants, β-blockers, and antiarrhythmics, occurs through the cytochrome P450 2D6 isoenzyme (debrisoquine hydroxylase). (bula de Perfenazina, Interações medicamentosas)

Os diuréticos de alça e tiazídicos aumentam a perda de potássio; a suplementação às vezes é prescrita junto com eles. (NIH Office of Dietary Supplements, Potassium)

Potassium-depleting agents (e.g., diuretics, Amphotericin B): When corticosteroids are administered concomitantly with potassium-depleting agents, patients should be observed closely for development of hypokalemia. (bula de Prednisolona, Interações medicamentosas)

Potassium-Depleting Agents (e.g., Diuretics, Amphotericin B) When corticosteroids are administered concomitantly with potassium-depleting agents, patients should be observed closely for development of hypokalemia. (bula de Prednisona, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (bula de Protriptilina, Advertências)

Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents ( i.e., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. (bula de Triancinolona, Interações medicamentosas)

Because of its relative beta 1 cardio-selectivity, however, metoprolol tartrate may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

Os diuréticos tiazídicos aumentam a perda de zinco na urina com o uso prolongado. (NIH Office of Dietary Supplements, Zinc)

Beta-adrenergic blocking agents: Coadministration of beta-adrenergic blocking agents did not have any effect on either the safety or efficacy of ibutilide in the clinical trials. (bula de Ibutilida, Interações medicamentosas)

Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (bula de Pamidronato, Interações medicamentosas)

Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (bula de Ropinirol, Interações medicamentosas)

Table 5: Sevelamer Drug Interactions Oral drugs for which sevelamer did not alter the pharmacokinetics when administered concomitantly Digoxin Enalapril Iron Metoprolol Warfarin Oral drugs that have demonstrated interaction with sevelamer and are to be dosed separately from sevelamer carbonate Dosing Recommendations Ciprofloxacin Take at least 2 hours before… (bula de Sevelâmer, Interações medicamentosas)