Selegilina: interakcje

During or within 14 days following the administration of monoamine oxidase inhibitors, hypertensive crises may result. (etykieta leku Amfepramon (dietylopropion), Przeciwwskazania)

Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [ see Warnings and Precautions (5.7) , Drug Interactions (7.1) ]. (etykieta leku Amfetamina, Przeciwwskazania)

Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [see Adverse Reactions ( 6.2 )] . taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive… (etykieta leku Amfetamina + deksamfetamina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (etykieta leku Apraklonidyna, Przeciwwskazania)

Taking, or within 14 days of stopping, a monoamine oxidase inhibitor (MAOI) [see Drug Interactions (7) ] . (etykieta leku Atomoksetyna, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (etykieta leku Benzfetamina, Przeciwwskazania)

• Concomitant use of other drugs in the monoamine oxidase inhibitor (MAOI) class or other drugs that are potent inhibitors of monoamine oxidase, including linezolid), because of an increased risk for hypertensive crisis [see Warnings and Precautions (5.1)]. (etykieta leku Selegilina, Przeciwwskazania)

• Concomitant use of dextromethorphan, because of reported episodes of psychosis or bizarre behavior. (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

The use of monoamine oxidase inhibitors (MAOIs) intended to treat depression with buspirone or within 14 days of stopping treatment with buspirone is contraindicated because of an increased risk of serotonin syndrome and/or elevated blood pressure. (etykieta leku Buspiron, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Monoamine oxidase inhibitor therapy (See DRUG INTERACTIONS ). (etykieta leku Cyproheptadyna, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Warnings and Drug Interactions ]. (etykieta leku Deksamfetamina, Przeciwwskazania)

Antihistamines are also contraindicated in the following conditions: Hypersensitivity to dexchlorpheniramine maleate or other antihistamines of similar chemical structure Monoamine oxidase inhibitor therapy (See Drug Interaction section) (etykieta leku Dekschlorfeniramina, Przeciwwskazania)

• Concomitant treatment with monoamine oxidase inhibitors (MAOIs) or within 14 days following discontinuation of treatment with an MAOI, because of the risk of hypertensive crises [see Drug Interactions ( 7.1 )] . (etykieta leku Deksmetylofenidat, Przeciwwskazania)

• Concomitant use of dextromethorphan, because of reported episodes of psychosis or bizarre behavior. (etykieta leku Selegilina, Przeciwwskazania)

• Concomitant use of dextromethorphan, because of reported episodes of psychosis or bizarre behavior. (etykieta leku Selegilina, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Taking monoamine oxidase inhibitors (MAOIs). (etykieta leku Deutetrabenazyna, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Avoid use of diphenoxylate hydrochloride and atropine sulfate in patients who take MAOIs and monitor for signs and symptoms of hypertensive crisis (headache, hyperthermia, hypertension). (etykieta leku Difenoksylat + atropina, Interakcje z innymi lekami)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

…Known hypersensitivity to doxylamine succinate, other ethanolamine derivative antihistamines, pyridoxine hydrochloride or any inactive ingredient in the formulation Monoamine oxidase (MAO) inhibitors intensify and prolong the adverse central nervous system effects of doxylamine succinate and pyridoxine hydrochloride delayed-release tablets [ see Drug Interactions… (etykieta leku Doksylamina + pirydoksyna, Przeciwwskazania)

However, based on mechanism of action, the use of non-selective MAO inhibitors and linezolid should be avoided as there is a potential for increased blood pressure when taken with NORTHERA. (etykieta leku Droksydopa, Interakcje z innymi lekami)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Łączenie dziurawca z lekami przeciwdepresyjnymi i innymi lekami serotoninergicznymi zwiększa ryzyko zespołu serotoninowego. (NCCIH, St. John's Wort)

Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during co-administration of triptans and SSRIs, SNRIs, TCAs and MAO inhibitors [see Warnings and Precautions (5.7) ]. (etykieta leku Eletryptan, Interakcje z innymi lekami)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

…coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension, pulmonary hypertension) • During or within 14 days following the administration of monoamine oxidase inhibitors • Hyperthyroidism • Glaucoma • Agitated states • History of drug abuse • Pregnancy (see PRECAUTIONS, Pregnancy ) • Nursing • Use in combination with other… (etykieta leku Fendimetrazyna, Przeciwwskazania)

• Concomitant use of other drugs in the monoamine oxidase inhibitor (MAOI) class or other drugs that are potent inhibitors of monoamine oxidase, including linezolid), because of an increased risk for hypertensive crisis [see Warnings and Precautions (5.1)]. (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

…cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension) • During or within 14 days following the administration of monoamine oxidase inhibitors • Hyperthyroidism • Glaucoma • Agitated states • History of drug abuse • Pregnancy [ see Use in Specific Populations () ] • Nursing [ see Use in Specific… (etykieta leku Fentermina, Przeciwwskazania)

…Warnings and Precautions (5.1) and Use in Specific Populations (8.1) ] With glaucoma [see Warnings and Precautions (5.3) ] With hyperthyroidism Taking or within 14 days of stopping a monoamine oxidase inhibitors [see Drug Interactions (7) ] With known hypersensitivity to phentermine, topiramate or any of the excipients in phentermine and topiramate extended-release… (etykieta leku Fentermina + topiramat, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Selective Serotonin Reuptake Inhibitors / Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during combined use of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [ see Warnings and Precautions (5.7) ]. (etykieta leku Frowatryptan, Interakcje z innymi lekami)

Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of granisetron and other serotonergic drugs. (etykieta leku Granisetron, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

• Concomitant use of other drugs in the monoamine oxidase inhibitor (MAOI) class or other drugs that are potent inhibitors of monoamine oxidase, including linezolid), because of an increased risk for hypertensive crisis [see Warnings and Precautions (5.1)]. (etykieta leku Selegilina, Przeciwwskazania)

Concomitant use of monoamine oxidase inhibitors (MAOIs). (etykieta leku Karbamazepina, Przeciwwskazania)

Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with levodopa or carbidopa-levodopa combination products with or without carbidopa. (etykieta leku Karbidopa, Przeciwwskazania)

DUOPA is contraindicated in patients who are currently taking a nonselective monoamine oxidase (MAO) inhibitor (e.g., phenelzine and tranylcypromine) or have recently (within 2 weeks) taken a nonselective MAO inhibitor. (etykieta leku Karbidopa + lewodopa, Przeciwwskazania)

Carbidopa, levodopa and entacapone tablets is contraindicated in patients: Taking nonselective monoamine oxidase (MAO) inhibitors (e.g., phenelzine and tranylcypromine). (etykieta leku Karbidopa + lewodopa + entakapon, Przeciwwskazania)

…because deaths have been reported in this age group [see Warnings and Precautions (5.1)]. patients who are hypersensitive to carbinoxamine maleate or any of the inactive ingredients in Carbinoxamine Maleate Extended-Release Oral Suspension [see Warnings and Precautions (5.4)]. patients who are taking monoamine oxidase inhibitors (MAOI) [see Drug Interactions (7)]. (etykieta leku Karbinoksamina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

INBRIJA is contraindicated in patients currently taking a nonselective monoamine oxidase (MAO) inhibitor (e.g., phenelzine and tranylcypromine) or who have recently (within 2 weeks) taken a nonselective MAO inhibitor. (etykieta leku Lewodopa, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

MAO Inhibitors ZELAPAR is contraindicated for concomitant use with other drugs in the MAOI class or other drugs that are potent inhibitors of monoamine oxidase (including linezolid, an oxazolidinone antibacterial, which also has reversible nonselective MAO inhibition activity) because of the increased risk for hypertensive crisis [see Contraindications (4) and… (etykieta leku Selegilina, Interakcje z innymi lekami)

Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Warnings and Precautions (5.7) and Drug Interactions (7.1) ] . (etykieta leku Lisdeksamfetamina, Przeciwwskazania)

If concomitant use of lithium with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms. (etykieta leku Lit, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [see Adverse Reactions ( 6 )]. taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because… (etykieta leku Metamfetamina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

In one study in hypertensive patients, intravenously administered metoclopramide was shown to release catecholamines; hence, avoid use in patients with hypertension or in patients taking monoamine oxidase inhibitors [see Drug Interactions ( 7.1 )] . (etykieta leku Metoklopramid, Ostrzeżenia i środki ostrożności)

CONTRAINDICATIONS Methyldopa is contraindicated in patients: – with active hepatic disease, such as acute hepatitis and active cirrhosis. – with liver disorders previously associated with methyldopa therapy (see WARNINGS ). – with hypersensitivity to any component of this product. – on therapy with monoamine oxidase (MAO) inhibitors. (etykieta leku Metyldopa, Przeciwwskazania)

Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (etykieta leku Metylofenidat, Przeciwwskazania)

Avoid use of MAO inhibitors or linezolid with midodrine. (etykieta leku Midodryna, Interakcje z innymi lekami)

• Serotonin Syndrome and MAOIs: Do not use MAOIs intended to treat psychiatric disorders with milnacipran hydrochloride or within 5 days of stopping treatment with milnacipran hydrochloride. (etykieta leku Milnacypran, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during co-administration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)] . (etykieta leku Naratryptan, Interakcje z innymi lekami)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

…serotonin reuptake inhibitors-SSRIs, serotonin-norepinephrine reuptake inhibitors-SNRIs, tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants) and a non-selective MAOI (e.g., phenelzine, tranylcypromine) or selective MAO-B inhibitors, such as selegiline (ELDEPRYL), rasagiline (AZILECT), and olanzapine (Zydis) selegiline (ZELAPAR). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of Ondansetron Injection and other serotonergic drugs. (etykieta leku Ondansetron, Ostrzeżenia i środki ostrożności)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of POSFREA and other serotonergic drugs. (etykieta leku Palonosetron, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• Concomitant use of dextromethorphan, because of reported episodes of psychosis or bizarre behavior. (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. (etykieta leku Pseudoefedryna, Ostrzeżenia)

…serotonin reuptake inhibitors-SSRIs, serotonin-norepinephrine reuptake inhibitors-SNRIs, tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants) and a non-selective MAOI (e.g., phenelzine, tranylcypromine) or selective MAO-B inhibitors, such as selegiline (ELDEPRYL), rasagiline (AZILECT), and olanzapine (Zydis) selegiline (ZELAPAR). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

Monoamine Oxidase Inhibitors MAXALT is contraindicated in patients taking MAO-A inhibitors and non-selective MAO inhibitors. (etykieta leku Ryzatryptan, Interakcje z innymi lekami)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

SUNOSI is contraindicated in patients receiving concomitant treatment with monoamine oxidase (MAO) inhibitors, or within 14 days following discontinuation of monoamine oxidase inhibitor, because of the risk of hypertensive reaction [see Drug Interactions ( 7.1 )] . (etykieta leku Solriamfetol, Przeciwwskazania)

Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)] . (etykieta leku Sumatryptan, Interakcje z innymi lekami)

Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Clinical Impact: Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.11)] . (etykieta leku Sumatryptan + naproksen, Interakcje z innymi lekami)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

• Taking monoamine oxidase inhibitors (MAOIs). (etykieta leku Tetrabenazyna, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

ZELAPAR is contraindicated in patients with: • Concomitant use of opioid drugs (e.g., meperidine, tramadol, or methadone). (etykieta leku Selegilina, Przeciwwskazania)

…serotonin reuptake inhibitors-SSRIs, serotonin-norepinephrine reuptake inhibitors-SNRIs, tricyclic antidepressants, tetracyclic antidepressants, triazolopyridine antidepressants) and a non-selective MAOI (e.g., phenelzine, tranylcypromine) or selective MAO-B inhibitors, such as selegiline (ELDEPRYL), rasagiline (AZILECT), and olanzapine (Zydis) selegiline (ZELAPAR). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

John’s wort or cyclobenzaprine (a tricyclic muscle relaxant). (etykieta leku Selegilina, Przeciwwskazania)

Dose adjustments due to drug interactions ( 2.4 , 7.1 ): Factors Dose Adjustments for INGREZZA and INGREZZA SPRINKLE Use of MAOIs with INGREZZA or INGREZZA SPRINKLE Avoid concomitant use with MAOIs. (etykieta leku Walbenazyna, Interakcje z innymi lekami)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Qelbree is contraindicated in patients: receiving concomitant treatment with monoamine oxidase inhibitors (MAOI), or within 14 days following discontinuing an MAOI, because of an increased risk of hypertensive crisis [see Drug Interactions (7.1) ] . receiving concomitant administration of sensitive CYP1A2 substrates or CYP1A2 substrates with a narrow therapeutic… (etykieta leku Wiloksazyna, Przeciwwskazania)

• May cause serotonin syndrome when used with antidepressants (5.2) (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

• Concomitant use of monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs. (etykieta leku Zyprazydon, Przeciwwskazania)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Monoamine oxidase inhibitors may result in increased hypotension. (etykieta leku Brymonidyna, Interakcje z innymi lekami)

Monoamine oxidase inhibitors may result in increased hypotension. (etykieta leku Brymonidyna + tymolol, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

…of Adverse Reactions Due to Drug Interactions with MARCAINE WITH EPINEPHRINE Risk of Severe, Persistent Hypertension Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving monoamine oxidase inhibitors… (etykieta leku Bupiwakaina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drug Interactions The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors. (etykieta leku Butalbital + paracetamol, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. (etykieta leku Chloroprokaina, Środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

…be given to the pharmacology of the agents employed particularly with compounds that may potentiate or be potentiated by the action of Valium, such as phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, sedative antihistamines, narcotics, barbiturates, MAO inhibitors and other antidepressants. (etykieta leku Diazepam, Interakcje z innymi lekami)

…drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (etykieta leku Dicykloweryna, Interakcje z innymi lekami)

MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. (etykieta leku Difenhydramina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

…1) clinically significant bradycardia (less than 50 bpm), 2) any clinically significant cardiac disease, 3) treatment with Class I and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval (see PRECAUTIONS, Drug Interactions ), and 6) electrolyte imbalance,… (etykieta leku Droperydol, Ostrzeżenia)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

The action of the benzodiazepines may be potentiated by anticonvulsants, antihistamines, alcohol, barbiturates, monoamine oxidase inhibitors, narcotics, phenothiazines, psychotropic medications, or other drugs that produce CNS depression. (etykieta leku Estazolam, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

…Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (etykieta leku Glibenklamid, Interakcje z innymi lekami)

…steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. (etykieta leku Glimepiryd, Interakcje z innymi lekami)

…increase the susceptibility to and/or intensity of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, nonsteroidal anti-inflammatory… (etykieta leku Glipizyd, Interakcje z innymi lekami)

Glipizide: The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents. (etykieta leku Glipizyd + metformina, Środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drug Interactions MAO inhibitors should be used with caution in patients receiving hydralazine. (etykieta leku Hydralazyna, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. (etykieta leku Insulina aspart, Interakcje z innymi lekami)

…Degludec Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (etykieta leku Insulina degludec, Interakcje z innymi lekami)

…with LEVEMIR Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (etykieta leku Insulina detemir, Interakcje z innymi lekami)

…Glargine-yfgn Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors,… (etykieta leku Insulina glargine, Interakcje z innymi lekami)

Clinically Significant Drug Interactions with LYUMJEV Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (etykieta leku Insulina lispro, Interakcje z innymi lekami)

…Significant Drug Interactions with AFREZZA Antidiabetic agents, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blocking Agents, Disopyramide, Fibrates, Fluoxetine, Monoamine Oxidase Inhibitors, Pentoxifylline, Pramlintide, Salicylates, Somatostatin Analogs (e.g., octreotide), and Sulfonamide Antibiotics Prevention or Management Monitor blood glucose… (etykieta leku Insulina ludzka krótko działająca, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Concomitant Use with MAO Inhibitors Concomitant use of MAO inhibitors and inhalational anesthetics may increase the risk of hemodynamic instability during surgery or medical procedures. (etykieta leku Izofluran, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. (etykieta leku Karwedilol, Interakcje z innymi lekami)

Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of antihistamines. (etykieta leku Klemastyna, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

…Interactions The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. (etykieta leku Klonazepam, Interakcje z innymi lekami)

The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants. (etykieta leku Klorazepan, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Monoamine-oxidase inhibitors: Concomitant administration may potentiate the effects and toxicity of monoamine-oxidase inhibitors. (etykieta leku Kokaina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Clinically Significant Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. (etykieta leku Lidokaina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Likewise, solutions of mepivacaine containing a vasoconstrictor, such as epinephrine, should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types, because severe prolonged hypertension may result. (etykieta leku Mepiwakaina, Ostrzeżenia)

Catecholamine depleting drugs (e.g., reserpine, monoamine oxidase (MAO) inhibitors) may have an additive effect when given with beta-blocking agents. (etykieta leku Metoprolol, Interakcje z innymi lekami)

Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

…Nateglinide Drugs That May Increase the Blood-Glucose-Lowering Effect of Nateglinide and Susceptibility to Hypoglycemia Drugs: Nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, monoamine oxidase inhibitors, non-selective beta-adrenergic-blocking agents, anabolic hormones (e.g., methandrostenolone), guanethidine, gymnema sylvestre, glucomannan, thioctic acid,… (etykieta leku Nateglinid, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

…steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. (etykieta leku Pioglitazon + glimepiryd, Interakcje z innymi lekami)

Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Monoamine Oxidase Inhibitors (MAOI) Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. (etykieta leku Prometazyna, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Non-selective MAO-inhibitors Concomitant use of MAO inhibitors and inhalational anesthetics may increase the risk of hemodynamic instability during surgery or medical procedures. (etykieta leku Sewofluran, Interakcje z innymi lekami)

The neuromuscular blocking effect of succinylcholine may be enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives, glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma cholinesterase [see Warnings and Precautions (5.9) ]. (etykieta leku Suksametonium, Interakcje z innymi lekami)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Baseline treatment with dopamine agonists or selegiline did not appear to increase the likelihood of experiencing orthostatic hypotension when treated with Tolcapone tablets. (etykieta leku Tolkapon, Środki ostrożności)

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution. (etykieta leku Selegilina, Interakcje z innymi lekami)

Withdrawal Emergent Hyperpyrexia and Confusion Although not reported with ZELAPAR in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with… (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Uncontrolled hypertension has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication (ephedrine). (etykieta leku Selegilina, Ostrzeżenia i środki ostrożności)

Drug Interactions Since the chemical structure of difenoxin hydrochloride is similar to meperidine hydrochloride, the concurrent use of MOTOFEN ® with monoamine oxidase inhibitors may, in theory, precipitate a hypertensive crisis. (etykieta leku Difenoksyna + atropina, Interakcje z innymi lekami)

Entacapone can be taken concomitantly with a selective MAO-B inhibitor (e.g., selegiline). (etykieta leku Entakapon, Ostrzeżenia)

Examples: Nonsteroidal anti-inflammatory agents and other highly protein-boind drugs, salicylcates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, beta-adrenergic blocking agents; potentially with ciprofloxacin, micronazole. (etykieta leku Glibenklamid + metformina, Interakcje z innymi lekami)

Antidepressants: The hypotensive effect of MAO inhibitors or tricyclic antidepressants may be exacerbated when administered with beta-blockers. (etykieta leku Propranolol, Interakcje z innymi lekami)

Examples: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, nonsteroidal anti-inflammatory agents (NSAIDs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (etykieta leku Repaglinid, Interakcje z innymi lekami)

Drugs predominantly metabolized by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Type B. (etykieta leku Terbinafina, Interakcje z innymi lekami)

Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. (etykieta leku Triheksyfenidyl, Interakcje z innymi lekami)

Serotonin Syndrome Serotonin syndrome may occur with triptans, including zolmitriptan, particularly during co-administration with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and MAO inhibitors [see Drug Interactions ( 7.5 )] . (etykieta leku Zolmitryptan, Ostrzeżenia i środki ostrożności)