Interações de Sertralina

Sertralina (Zoloft), ISRS, tem 351 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 149; moderadas: 164; leves: 31; casos em que uma bula relata não haver interação significativa: 7). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

A sertralina é um antidepressivo ISRS vendido como Zoloft e amplamente como genérico. Ela aumenta a quantidade de serotonina disponível no cérebro. É aprovada para depressão maior, transtorno obsessivo-compulsivo, transtorno do pânico, transtorno de estresse pós-traumático, transtorno de ansiedade social e transtorno disfórico pré-menstrual. É apresentada em comprimido ou em concentrado oral que é diluído antes do uso, e geralmente é tomada uma vez ao dia, de manhã ou à noite, com ou sem alimentos.

Interações segundo a bula

Interações graves (149)

  • AlfuzosinaalfabloqueadorGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • AlmotriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • AmiodaronaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Amitriptilinaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Amoxapinaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Anagrelidamedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Anfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Anfetamina, Advertências e precauções)

  • Anfetamina + dextroanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans), but also during overdosage situations. (bula de Anfetamina + dextroanfetamina, Advertências e precauções)

  • AsenapinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Azitromicinaantibiótico macrolídeoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Azul de metilenoinibidor da MAOGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • Beladona + ópioopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Beladona + ópio, Interações medicamentosas)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • BuprenorfinaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Buprenorfina, Interações medicamentosas)

  • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Buprenorfina + naloxona, Interações medicamentosas)

  • Buspironamedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Intervention: Avoid concomitant use Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Butalbital + ácido acetilsalicílico + cafeína + codeína, Interações medicamentosas)

  • • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Butalbital + paracetamol + cafeína + codeína, Interações medicamentosas)

  • ButorfanolopioideGrave

    …medical attention if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see WARNINGS ; ADVERSE REACTIONS ].‎ Serotonin Syndrome Inform patients that butorphanol tartrate could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Butorfanol, Precauções)

  • CarbamazepinaanticonvulsivanteGrave

    Known hypersensitivity to tricyclic antidepressants ( 4 ) (bula de Carbamazepina, Contraindicações)

  • Cetoconazolantifúngico azólicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Ciclobenzaprinarelaxante muscularGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • CiprofloxacinofluoroquinolonaGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • CitalopramISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Claritromicinaantibiótico macrolídeoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Clomipraminaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • CloroquinaantimaláricoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • ClorpromazinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • ClozapinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • CodeínaopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Codeína, Interações medicamentosas)

  • Desipraminaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Deutetrabenazinainibidor do VMAT2Grave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Dextroanfetaminaestimulante do SNCGrave

    Serotonergic Drugs The concomitant use of dextroamphetamine sulfate and serotonergic drugs increases the risk of serotonin syndrome. (bula de Dextroanfetamina, Interações medicamentosas)

  • Dextrometorfanomedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Dextrometorfano + quinidinamedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Di-hidroergotaminaalcaloide do ergotGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • DisopiramidaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • DofetilidaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Doxepinaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • DronedaronaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Droperidolantagonista da dopaminaGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • DuloxetinaIRSNGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • EdoxabanaanticoagulanteGrave

    Anticoagulants, Antiplatelets, Thrombolytics, and Selective Serotonin Reuptake Inhibitors (SSRIs)/Serotonin Norepinephrine Reuptake Inhibitors (SNRIs): Avoid concomitant use due to increased risk of bleeding. (bula de Edoxabana, Interações medicamentosas)

  • EletriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Eritromicinaantibiótico macrolídeoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Erva-de-são-joão (hipérico)Fitoterápicos e suplementosGrave

    Combinar a erva-de-são-joão (hipérico) com antidepressivos e outros medicamentos serotoninérgicos aumenta o risco de síndrome serotoninérgica. (NCCIH, St. John's Wort)

  • EscitalopramISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Fenelzinainibidor da MAOGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • FentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Fentanila, Advertências e precauções)

  • FingolimodeimunossupressorGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • FlecainidaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Flibanserinadepressor do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Fluconazolantifúngico azólicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • FlumazenilbenzodiazepínicoGrave

    THESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE. (bula de Flumazenil, Advertência em caixa preta)

  • FluoxetinaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • FluvoxaminaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • FrovatriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Granisetronamedicamento que prolonga o intervalo QTGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • HaloperidolantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • HidrocodonaopioideGrave

    Example: lactulose Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona, Interações medicamentosas)

  • Serotonergic drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + clorfeniramina, Interações medicamentosas)

  • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidrocodona + homatropina, Interações medicamentosas)

  • S er otonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Hidrocodona + ibuprofeno, Precauções)

  • Serotonin Syndrome Inform patients that hydrocodone bitartrate and acetaminophen tablets could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Hidrocodona + paracetamol, Precauções)

  • HidromorfonaopioideGrave

    • Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Hidromorfona, Interações medicamentosas)

  • Hidroxicloroquinamedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Hidroxizinaanti-histamínicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • IbutilidaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • IloperidonaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Imipraminaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • IsoniazidaantibióticoGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • LevofloxacinofluoroquinolonaGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • LevorfanolopioideGrave

    Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Levorfanol, Precauções)

  • LinezolidaantibióticoGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • Lisdexanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Lisdexanfetamina, Advertências e precauções)

  • Lítiomedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Loperamidamedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • LorazepambenzodiazepínicoGrave

    LOREEV XR should not be used in such patients without adequate antidepressant therapy. (bula de Lorazepam, Advertências e precauções)

  • MetadonaopioideGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Metanfetaminaestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when coadministered with serotonergic agents (e.g., SSRIs, SNRIs, triptans), but also during overdosage situations. (bula de Metanfetamina, Advertências e precauções)

  • Metaxalonarelaxante muscularGrave

    Serotonin syndrome has resulted from concomitant use of metaxalone (within the recommended dosage range) and other serotonergic drugs [see Warnings and Precautions (5.1) ]. (bula de Metaxalona, Interações medicamentosas)

  • MilnacipranaIRSNGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • MirtazapinaantidepressivoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • MorfinaopioideGrave

    • Serotonergic Drugs: Concomitant use may result in serotonin syndrome. (bula de Morfina, Interações medicamentosas)

  • MoxifloxacinofluoroquinolonaGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • NaratriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • NefazodonaantidepressivoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Nilotinibemedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Nortriptilinaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • OfloxacinofluoroquinolonaGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Olanzapina + fluoxetinaantipsicóticoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • OliceridinaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Oliceridina, Interações medicamentosas)

  • Ondansetronamedicamento que prolonga o intervalo QTGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • OxicodonaopioideGrave

    Serotonergic Drug s: Concomitant use may result in serotonin syndrome. (bula de Oxicodona, Interações medicamentosas)

  • OximorfonaopioideGrave

    Serotonergic Drugs : Concomitant use may result in serotonin syndrome. (bula de Oximorfona, Interações medicamentosas)

  • PaliperidonaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Palonosetronamedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Paracetamol + codeína, Precauções)

  • ParoxetinaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Pentamidinamedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. (bula de Pentazocina + naloxona, Precauções)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • PimavanserinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • PimozidaantipsicóticoGrave

    Taking pimozide [see Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • Pitolisantomedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Posaconazolantifúngico azólicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • ProcainamidaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Prometazinaanti-histamínicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Prometazina + dextrometorfanoanti-histamínicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Protriptilinaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Prucalopridamedicamento serotoninérgicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • QuetiapinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • QuinidinaantiarrítmicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • QuininaantimaláricoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Ranolazinamedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Rasagilinainibidor da MAOGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • RemifentanilaopioideGrave

    • Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. (bula de Remifentanila, Advertências e precauções)

  • RisperidonaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • RizatriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Selegilinainibidor da MAOGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • SolifenacinaanticolinérgicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Solriamfetolestimulante do SNCGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • SotalolbetabloqueadorGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • SumatriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • TacrolimoimunossupressorGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Tamoxifenomodulador seletivo do receptor de estrogênioGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • TapentadolopioideGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Tetrabenazinainibidor do VMAT2Grave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • TioridazinaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • TolterodinaanticolinérgicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Toremifenomodulador seletivo do receptor de estrogênioGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • TramadolopioideGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Tranilciprominainibidor da MAOGrave

    Sertraline hydrochloride capsules are contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [see Warnings and Precautions ( 5.2 ), Drug Interactions ( 7.1 )] . (bula de Sertralina, Contraindicações)

  • TrazodonaantidepressivoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Trimipraminaantidepressivo tricíclicoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Trióxido de arsêniomedicamento que prolonga o intervalo QTGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Valbenazinainibidor do VMAT2Grave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • Vardenafilainibidor da PDE5Grave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • VenlafaxinaIRSNGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • VilazodonaISRSGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • Voriconazolantifúngico azólicoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • VortioxetinaantidepressivoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

  • ZiprasidonaantipsicóticoGrave

    Avoid the concomitant use of drugs known to prolong the QTc interval. (bula de Sertralina, Interações medicamentosas)

  • ZolmitriptanatriptanoGrave

    Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. (bula de Sertralina, Advertências e precauções)

Interações moderadas (164)

  • Acetazolamidainibidor da anidrase carbônicaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Ácido acetilsalicílico + dipiridamolantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Ácido etacrínicodiurético de alçaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Ácido mefenâmicoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Amiloridadiurético poupador de potássioModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Anfepramona (dietilpropiona)estimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • ApixabanaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Arformoterolagonista beta-adrenérgicoModerada

    MAO inhibitors, tricyclic antidepressants and drugs that prolong the QTc interval may potentiate effect on the cardiovascular system. (bula de Arformoterol, Interações medicamentosas)

  • ArgatrobanaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Armodafinilaestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Articaína + epinefrinaanestésico localModerada

    The administration of local anesthetic solutions containing epinephrine to patients receiving monoamine oxidase inhibitors, nonselective beta-adrenergic antagonists, or tricyclic antidepressants may produce severe, prolonged hypertension. (bula de Articaína + epinefrina, Interações medicamentosas)

  • Atenolol + clortalidonabetabloqueadorModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Benazepril + hidroclorotiazidainibidor da ECAModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Benzfetaminaestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Bisoprolol + hidroclorotiazidabetabloqueadorModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • BivalirudinaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Brimonidinaagonista alfa-adrenérgicoModerada

    Caution is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. (bula de Brimonidina, Interações medicamentosas)

  • Brimonidina + timololagonista alfa-adrenérgicoModerada

    CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol. (bula de Brimonidina + timolol, Interações medicamentosas)

  • Budesonida + formoterolcorticosteroideModerada

    Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. (bula de Budesonida + formoterol, Interações medicamentosas)

  • Bumetanidadiurético de alçaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Bupivacaínaanestésico localModerada

    …Interactions with MARCAINE WITH EPINEPHRINE Risk of Severe, Persistent Hypertension Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving monoamine oxidase inhibitors (MAOI) or tricyclic antidepressants may… (bula de Bupivacaína, Advertências e precauções)

  • Bupivacaína + epinefrinaanestésico localModerada

    …Interactions with MARCAINE WITH EPINEPHRINE Risk of Severe, Persistent Hypertension Due to Drug Interactions Between MARCAINE WITH EPINEPHRINE and Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Administration of MARCAINE WITH EPINEPHRINE (containing a vasoconstrictor) in patients receiving monoamine oxidase inhibitors (MAOI) or tricyclic antidepressants may… (bula de Bupivacaína + epinefrina, Advertências e precauções)

  • BupropionaantidepressivoModerada

    Drugs Metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). (bula de Bupropiona, Interações medicamentosas)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Candesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Cangrelorantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Carbidopa + levodopa + entacaponamedicamento dopaminérgicoModerada

    • Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) (bula de Carbidopa + levodopa + entacapona, Interações medicamentosas)

  • Carisoprodolrelaxante muscularModerada

    Since the sedative effects of carisoprodol and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive, appropriate caution should be exercised with patients who take more than one of these CNS depressants simultaneously. (bula de Carisoprodol, Advertências e precauções)

  • CelecoxibeAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • CetoprofenoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • CetorolacoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Cilostazolantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Cimetidinabloqueador H2Moderada

    …apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these drugs. (bula de Cimetidina, Interações medicamentosas)

  • Cinacalceteinibidor da CYP2D6Moderada

    Dose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6 (e.g., desipramine, metoprolol, and carvedilol) and particularly those with a narrow therapeutic index (e.g., flecainide and most tricyclic antidepressants) [see Clinical Pharmacology ( 12.3 )] . (bula de Cinacalcete, Interações medicamentosas)

  • ClonazepambenzodiazepínicoModerada

    …Interactions The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. (bula de Clonazepam, Interações medicamentosas)

  • Clonidinaagonista alfa-adrenérgicoModerada

    Tricyclic antidepressants Clinical Implication Concomitant use of tricyclic antidepressants with clonidine can increase blood pressure and may counteract the hypotensive effects of clonidine. (bula de Clonidina, Interações medicamentosas)

  • Clopidogrelantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • ClorazepatobenzodiazepínicoModerada

    The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants. (bula de Clorazepato, Interações medicamentosas)

  • Cloroprocaínaanestésico localModerada

    Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. (bula de Cloroprocaína, Precauções)

  • Clorotiazidadiurético tiazídicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Clortalidonadiurético tiazídicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Cocaínaanestésico localModerada

    Sympathomimetics, postganglionic blocking agents, and tricyclic antidepressants: Concomitant administration may increase the risk of cardiovascular adverse reactions. (bula de Cocaína, Interações medicamentosas)

  • DabigatranaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Daridorexantosedativo-hipnóticoModerada

    Co-administration with other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants, alcohol) increases the risk of CNS depression, which can cause daytime impairment. (bula de Daridorexanto, Advertências e precauções)

  • DarifenacinaanticolinérgicoModerada

    Caution should be taken when darifenacin extended-release tablets is used concomitantly with medications that are predominantly metabolized by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine and tricyclic antidepressants ( 7.2 ) (bula de Darifenacina, Interações medicamentosas)

  • DarunavirantirretroviralModerada

    Antidepressants : Selective Serotonin Reuptake Inhibitors (SSRIs): paroxetine, sertraline ↓ paroxetine ↓ sertraline If either sertraline or paroxetine is initiated in patients receiving PREZISTA/ritonavir, dose titrating the SSRI based on a clinical assessment of antidepressant response is recommended. (bula de Darunavir, Interações medicamentosas)

  • Darunavir + cobicistateantirretroviralModerada

    Antidepressants: Selective Serotonin Reuptake Inhibitors (SSRIs): e.g. paroxetine, sertraline SSRIs: effects unknown When co-administering with SSRIs, TCAs, or trazodone, careful dose titration of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant response are recommended. (bula de Darunavir + cobicistate, Interações medicamentosas)

  • …that may Increase Risk of Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin… (bula de Desmopressina, Interações medicamentosas)

  • Dexmetilfenidatoestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • DiazepambenzodiazepínicoModerada

    …be given to the pharmacology of the agents employed particularly with compounds that may potentiate or be potentiated by the action of Valium, such as phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, sedative antihistamines, narcotics, barbiturates, MAO inhibitors and other antidepressants. (bula de Diazepam, Interações medicamentosas)

  • DicicloverinaanticolinérgicoModerada

    …drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (bula de Dicicloverina, Interações medicamentosas)

  • DiclofenacoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • DiflunisalAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Dipiridamolantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Dorzolamida + timololinibidor da anidrase carbônicaModerada

    CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol. (bula de Dorzolamida + timolol, Interações medicamentosas)

  • DronabinolcanabinoideModerada

    Concomitant use of other drugs that cause dizziness, confusion, sedation, or somnolence such as CNS depressants may increase this effect (e.g., barbiturates, benzodiazepines, lithium, opioids, buspirone, scopolamine, antihistamines, tricyclic antidepressants, other anticholinergic agents, and muscle relaxants). (bula de Dronabinol, Advertências e precauções)

  • EfavirenzantirretroviralModerada

    Increases in sertraline dosage should be guided by clinical response. (bula de Efavirenz, Interações medicamentosas)

  • Efavirenz + lamivudina + tenofovirantirretroviralModerada

    Sertraline ↓ sertraline Increases in sertraline dosage should be guided by clinical response. (bula de Efavirenz + lamivudina + tenofovir, Interações medicamentosas)

  • Antidepressants: Selective Serotonin Reuptake Inhibitors (SSRIs) e.g., paroxetine Tricyclic Antidepressants (TCAs) e.g., amitriptyline desipramine imipramine nortriptyline bupropion trazodone ↑ SSRIs (except sertraline) ↑ TCAs ↑ trazodone Careful dosage titration of the antidepressant and monitoring for antidepressant response are recommended when coadministered… (bula de Elvitegravir + cobicistate + entricitabina + tenofovir, Interações medicamentosas)

  • Enalapril + hidroclorotiazidainibidor da ECAModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • EnoxaparinaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Epinefrina (adrenalina)simpaticomiméticoModerada

    • Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. (bula de Epinefrina (adrenalina), Interações medicamentosas)

  • Eplerenonaantagonista da aldosteronaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Eptifibatidaantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Ergotamina + cafeínaalcaloide do ergotModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • EscopolaminaanticolinérgicoModerada

    Concomitant use of other drugs that cause central nervous system (CNS) adverse reactions (e.g., alcohol, sedatives, hypnotics, opiates, and anxiolytics) or have anticholinergic properties (e.g., other belladonna alkaloids, sedating antihistamines, meclizine, tricyclic antidepressants, and muscle relaxants) may increase this effect [see Drug Interactions ( 7.1 )] . (bula de Escopolamina, Advertências e precauções)

  • Espironolactonaantagonista da aldosteronaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Espironolactona + hidroclorotiazidaantagonista da aldosteronaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Eszopiclonasedativo-hipnóticoModerada

    Additive effects occur with concomitant use of other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants, alcohol), including daytime use. (bula de Eszopiclona, Advertências e precauções)

  • EtodolacoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Fendimetrazinaestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • FenilefrinadescongestionanteModerada

    Agonistic Effects (increase in BIORPHEN blood pressure effect) can occur with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids. (bula de Fenilefrina, Interações medicamentosas)

  • FenitoínaanticonvulsivanteModerada

    Sertraline hydrochloride capsules may increase phenytoin concentrations. (bula de Sertralina, Interações medicamentosas)

  • FenoprofenoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Fenterminaestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Fentermina + topiramatoestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Fisostigminainibidor da colinesteraseModerada

    Acute cardiac arrest may be possible during treatment with tricyclic antidepressants; therefore, Anticholium should only be considered as an antidote for this indication while the patient has continuous ECG monitoring. (bula de Fisostigmina, Advertências e precauções)

  • FlurbiprofenoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Fluticasona + salmeterolcorticosteroideModerada

    Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. (bula de Fluticasona + salmeterol, Interações medicamentosas)

  • FondaparinuxanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Formoterolagonista beta-adrenérgicoModerada

    • MAO inhibitors, tricyclic antidepressants and drugs that prolong QTc interval may potentiate effect on the cardiovascular system. (bula de Formoterol, Interações medicamentosas)

  • FosamprenavirantirretroviralModerada

    Antidepressant: Paroxetine, trazodone ↓ Paroxetine Any paroxetine dose adjustment should be guided by clinical effect (tolerability and efficacy). ↑ Trazodone Adverse events of nausea, dizziness, hypotension, and syncope have been observed following coadministration of trazodone and ritonavir. (bula de Fosamprenavir, Interações medicamentosas)

  • FoscarneteantiviralModerada

    …prolongation and the potential for torsades de pointes, the use of FOSCAVIR should be avoided in combination with agents known to prolong the QT interval including Class IA (e.g., quinidine or procainamide) or Class III (e.g., dofetilide, amiodarone, sotalol) antiarrhythmic agents, phenothiazines, tricyclic antidepressants, and certain macrolides and fluoroquinolones. (bula de Foscarnete, Interações medicamentosas)

  • FosfenitoínaanticonvulsivanteModerada

    Other Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D Drugs whose level is decreased by phenytoin Anticoagulants Apixaban, dabigatran, edoxaban, rivaroxaban Antiepileptic drugs The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels… (bula de Fosfenitoína, Interações medicamentosas)

  • FosfomicinaantibióticoModerada

    Avoid co-administration of CONTEPO with drugs known to prolong the QT interval, such as class IA or class III antiarrhythmic medications, tricyclic antidepressants, macrolides, and antipsychotics [see Warnings and Precautions ( 5.2 )] . (bula de Fosfomicina, Interações medicamentosas)

  • Fosinopril + hidroclorotiazidainibidor da ECAModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Furosemidadiurético de alçaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • GefitinibeModerada

    Increase IRESSA to 500 mg daily in patients receiving a strong CYP3A4 inducer (e.g., rifampicin, phenytoin, or tricyclic antidepressant) and resume IRESSA at 250 mg 7 days after discontinuation of the strong inducer [see Dosage and Administration (2.4) , Clinical Pharmacology (12.3) ] . (bula de Gefitinibe, Interações medicamentosas)

  • GlicopirrônioanticolinérgicoModerada

    Other Anticholinergic Drugs There is potential for an additive interaction between glycopyrrolate and concomitantly used anticholinergic drugs (e.g., tricyclic antidepressants, anti-epileptics, class I antiarrhythmics, anti­-spasmodics, amantadine) resulting in increased anticholinergic adverse reactions. (bula de Glicopirrônio, Interações medicamentosas)

  • HeparinaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Hidroclorotiazidadiurético tiazídicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • IbuprofenoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Indapamidadiurético tiazídicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • IndometacinaAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Ipratrópio + salbutamolanticolinérgicoModerada

    Monoamine Oxidase Inhibitors or Tricyclic Antidepressants Ipratropium Bromide and Albuterol Sulfate Inhalation Solution should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents because the action of albuterol sulfate on the cardiovascular… (bula de Ipratrópio + salbutamol, Interações medicamentosas)

  • Irbesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Isoprenalina (isoproterenol)agonista beta-adrenérgicoModerada

    Drugs that may potentiate clinical response of Isoproterenol Clinical Impact The effects of isoproterenol may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine. (bula de Isoprenalina (isoproterenol), Interações medicamentosas)

  • Itraconazolantifúngico azólicoModerada

    SSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions. (bula de Itraconazol, Interações medicamentosas)

  • Lemborexantosedativo-hipnóticoModerada

    Co-administration with other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants, alcohol) increases the risk of CNS depression, which can cause daytime impairment. (bula de Lemborexanto, Advertências e precauções)

  • Levossalbutamolagonista beta-adrenérgicoModerada

    Monoamine oxidase inhibitors (MAOs) or tricyclic antidepressants : May potentiate effect of albuterol on the cardiovascular system. (bula de Levossalbutamol, Interações medicamentosas)

  • Levotiroxinahormônio tireoidianoModerada

    Administration of sertraline in patients stabilized on levothyroxine may result in increased levothyroxine requirements. (bula de Levotiroxina, Interações medicamentosas)

  • Lidocaínaanestésico localModerada

    Clinically Significant Drug Interactions The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. (bula de Lidocaína, Interações medicamentosas)

  • Lidocaína + epinefrinaanestésico localModerada

    …Adverse Reactions Due to Drug Interactions with FLAVALTA Risk of Severe, Persistent Hypertension Due to Drug Interactions Between FLAVALTA and Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Administration of FLAVALTA (containing a vasoconstrictor, epinephrine) in patients receiving monoamine oxidase inhibitors (MAOI), or tricyclic antidepressants may result… (bula de Lidocaína + epinefrina, Advertências e precauções)

  • Liotironinahormônio tireoidianoModerada

    Administration of sertraline in patients stabilized on liothyronine sodium may result in increased liothyronine sodium requirements. (bula de Liotironina, Interações medicamentosas)

  • Lisinopril + hidroclorotiazidainibidor da ECAModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Lopinavir + ritonavirantirretroviralModerada

    Antidepressant: bupropion ↓ bupropion ↓ active metabolite, hydroxybupropion Patients receiving KALETRA and bupropion concurrently should be monitored for an adequate clinical response to bupropion. (bula de Lopinavir + ritonavir, Interações medicamentosas)

  • Losartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • LumateperonaantipsicóticoModerada

    Monitor all antidepressant-treated patients, especially during the initial few months of anti-depressant drug therapy, and at times of dosage changes. (bula de Lumateperona, Advertências e precauções)

  • LurasidonaantipsicóticoModerada

    Activation of Mania/Hypomania Antidepressant treatment can increase the risk of developing a manic or hypomanic episode, particularly in patients with bipolar disorder. (bula de Lurasidona, Advertências e precauções)

  • MefloquinaantimaláricoModerada

    Other Drugs that Prolong the QTc Interval Coadministration of other drugs known to alter cardiac conduction (e.g., anti-arrhythmic or beta-adrenergic blocking agents, calcium channel blockers, antihistamines or H 1 -blocking agents, tricyclic antidepressants and phenothiazines) might also contribute to a prolongation of the QTc interval. (bula de Mefloquina, Interações medicamentosas)

  • MeloxicamAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Mepivacaínaanestésico localModerada

    Likewise, solutions of mepivacaine containing a vasoconstrictor, such as epinephrine, should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types, because severe prolonged hypertension may result. (bula de Mepivacaína, Advertências)

  • MetilescopolaminaanticolinérgicoModerada

    Drug interactions Additive anticholinergic effects may result from concomitant use with antipsychotics, tricyclic antidepressants, and other drugs with anticholinergic effects. (bula de Metilescopolamina, Interações medicamentosas)

  • Metilfenidatoestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • Metolazonadiurético tiazídicoModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Metoprolol + hidroclorotiazidabetabloqueadorModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Modafinilaestimulante do SNCModerada

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (bula de Sertralina, Advertências e precauções)

  • NabumetonaAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • NalbufinaopioideModerada

    Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system… (bula de Nalbufina, Interações medicamentosas)

  • Naltrexona + bupropionaantagonista opioideModerada

    Drugs Metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of antidepressants, (e.g., selective serotonin reuptake inhibitors and many tricyclics), antipsychotics (e.g., haloperidol, risperidone and thioridazine), beta-blockers (e.g., metoprolol) and Type 1C antiarrhythmics (e.g., propafenone and flecainide). (bula de Naltrexona + bupropiona, Interações medicamentosas)

  • NaproxenoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Nirmatrelvir + ritonavirantiviralModerada

    Antidepressants bupropion ↓ bupropion and active metabolite hydroxy-bupropion Monitor for an adequate clinical response to bupropion. trazodone ↑ trazodone Adverse reactions of nausea, dizziness, hypotension, and syncope have been observed following co-administration of trazodone and ritonavir. (bula de Nirmatrelvir + ritonavir, Interações medicamentosas)

  • Olmesartana + anlodipino + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Olmesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • OxaprozinaAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Oxibato de sódiodepressor do SNCModerada

    The concurrent use of Xyrem with other CNS depressants, including but not limited to opioid analgesics, benzodiazepines, sedating antidepressants or antipsychotics, sedating anti-epileptic drugs, general anesthetics, muscle relaxants, and/or illicit CNS depressants, may increase the risk of respiratory depression, hypotension, profound sedation, syncope, and… (bula de Oxibato de sódio, Advertências e precauções)

  • Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • PiroxicamAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Prasugrelantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Prilocaína + epinefrinaanestésico localModerada

    …Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration of local anesthetic injections containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. (bula de Prilocaína + epinefrina, Interações medicamentosas)

  • PropafenonaantiarrítmicoModerada

    Drugs that inhibit these CYP pathways (such as desipramine, paroxetine, ritonavir, sertraline for CYP2D6; ketoconazole, erythromycin, saquinavir, and grapefruit juice for CYP3A4; and amiodarone and tobacco smoke for CYP1A2) can be expected to cause increased plasma levels of propafenone. (bula de Propafenona, Advertências e precauções)

  • Quinapril + hidroclorotiazidainibidor da ECAModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • RifampicinaantibióticoModerada

    …5-HT 3 Receptor Antagonists Ondansetron Decrease exposure Statins Metabolized by CYP3A4 Simvastatin Decrease exposure Thiazolidinediones Rosiglitazone Decrease AUC by 66% Tricyclic Antidepressants Nortriptyline A tuberculosis treatment regimen including rifampin (600 mg/day), isoniazid (300 mg/day), pyrazinamide (500 mg 3× per day), and pyridoxine (25 mg) was… (bula de Rifampicina, Interações medicamentosas)

  • RifapentinaantibióticoModerada

    …levonorgestrel Immunosuppressants Cyclosporine, tacrolimus Methylxanthines Theophylline Narcotic analgesics Methadone Phosphodiesterase-5 (PDE-5) Inhibitors Sildenafil Thyroid preparations Levothyroxine Tricyclic antidepressants Amitriptyline, nortriptyline 7.5 Other Interactions The conversion of PRIFTIN to 25-desacetyl rifapentine is mediated by an esterase enzyme. (bula de Rifapentina, Interações medicamentosas)

  • RitonavirantirretroviralModerada

    Antidepressants: nefazodone, selective serotonin reuptake inhibitors (SSRIs): e.g. fluoxetine, paroxetine, tricyclics: e.g. amitriptyline, nortriptyline ↑ antidepressants A dose decrease may be needed for these drugs when co-administered with ritonavir. (bula de Ritonavir, Interações medicamentosas)

  • RivaroxabanaanticoagulanteModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Salbutamolagonista beta-adrenérgicoModerada

    Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. (bula de Salbutamol, Interações medicamentosas)

  • Salmeterolagonista beta-adrenérgicoModerada

    • Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. (bula de Salmeterol, Interações medicamentosas)

  • SalsalatoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • The efficacy of tricyclic antidepressants can decrease when coadministered with sulfamethoxazole and trimethoprim. (bula de Sulfametoxazol + trimetoprima, Interações medicamentosas)

  • SulindacoAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Suvorexantosedativo-hipnóticoModerada

    Co-administration with other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants, alcohol) increases the risk of CNS depression. (bula de Suvorexanto, Advertências e precauções)

  • Telmisartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • TemazepambenzodiazepínicoModerada

    The benzodiazepines, including temazepam, produce additive CNS-depressant effects when co-administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics. (bula de Temazepam, Interações medicamentosas)

  • Terbutalinaagonista beta-adrenérgicoModerada

    Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Terbutaline sulfate should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of terbutaline sulfate on the vascular system may be potentiated. (bula de Terbutalina, Precauções)

  • Ticagrelorantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Tirofibanaantiagregante plaquetárioModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Tizanidinarelaxante muscularModerada

    The CNS depressant effects of Zanaflex with alcohol and other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants) may be additive [see Drug Interactions ( 7.4 )] . (bula de Tizanidina, Advertências e precauções)

  • TolmetinaAINEModerada

    Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (bula de Sertralina, Advertências e precauções)

  • Torasemidadiurético de alçaModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Trianterenodiurético poupador de potássioModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Triantereno + hidroclorotiazidadiurético poupador de potássioModerada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • Umeclidínio + vilanterolanticolinérgicoModerada

    • Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. (bula de Umeclidínio + vilanterol, Interações medicamentosas)

  • Valsartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Moderada

    Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (bula de Sertralina, Advertências e precauções)

  • VarfarinaanticoagulanteModerada

    For patients taking warfarin, carefully monitor the international normalized ratio. (bula de Sertralina, Advertências e precauções)

  • VasopressinaModerada

    Drugs Suspected of Causing SIADH Use with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasostrict ® . (bula de Vasopressina, Interações medicamentosas)

  • Zaleplonasedativo-hipnóticoModerada

    Coadministration with other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants, alcohol) increases the risk of CNS depression. (bula de Zaleplona, Advertências)

  • Zolpidemsedativo-hipnóticoModerada

    Sertraline Concomitant administration of zolpidem and sertraline increases exposure to zolpidem [see Clinical Pharmacology (12.3) ] . (bula de Zolpidem, Interações medicamentosas)

Menções leves (31)

  • Abirateronainibidor da CYP2D6Leve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • Ácido valproicoanticonvulsivanteLeve

    In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation. (bula de Ácido valproico, Interações medicamentosas)

  • AlprazolambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • AtazanavirantirretroviralLeve

    Antidepressants: tricyclic antidepressants ↑ tricyclic antidepressants Coadministration with REYATAZ has the potential to produce serious and/or life-threatening adverse events and has not been studied. (bula de Atazanavir, Interações medicamentosas)

  • BenzatropinaanticolinérgicoLeve

    Paralytic ileus, hyperthermia and heat stroke, all of which have sometimes been fatal, have occurred in patients taking anticholinergic-type antiparkinsonism drugs, including benztropine mesylate, in combination with phenothiazines and/or tricyclic antidepressants. (bula de Benzatropina, Advertências)

  • BrexpiprazolantipsicóticoLeve

    However, there is substantial evidence from placebo-controlled maintenance studies in adults with MDD that antidepressants delay the recurrence of depression. (bula de Brexpiprazol, Advertências e precauções)

  • There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa-levodopa preparations. (bula de Carbidopa, Interações medicamentosas)

  • CariprazinaantipsicóticoLeve

    …placebo-controlled trials of adult patients with major depressive disorder, the proportion of patients with shifts in fasting glucose from normal (<100 mg/dL) to high (≥126 mg/dL) was greatest in the VRAYLAR 3 mg per day + antidepressant therapy arm (3.2%) compared with those taking VRAYLAR 1.5 mg per day + antidepressant therapy (2%) or those placebo-treated (1.3%). (bula de Cariprazina, Advertências e precauções)

  • ClobazambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • ClordiazepóxidobenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • Clordiazepóxido + clidíniobenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • Difenidraminaanti-histamínicoLeve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation. (bula de Divalproato de sódio (valproato), Interações medicamentosas)

  • EluxadolinaopioideLeve

    Other Serotonergic Drugs Clinical Impact: Concomitant use of sertraline hydrochloride capsules with other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St. (bula de Sertralina, Interações medicamentosas)

  • EstazolambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • EverolimoimunossupressorLeve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • Imatinibeinibidor da CYP3A4Leve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • These included patients with a history of seizures, epilepsy, cerebrovascular disorders, central nervous system anomalies or tumors, and in patients on concomitant medications that have been associated with convulsions such as bupropion and SSRIs. (bula de Leuprorrelina, Advertências e precauções)

  • LovastatinaestatinaLeve

    These include itraconazole, ketoconazole, posaconazole, voriconazole, the macrolide antibiotics erythromycin and clarithromycin, the ketolide antibiotic telithromycin, HIV protease inhibitors, boceprevir, telaprevir, the antidepressant nefazodone, or cobicistat-containing products. (bula de Lovastatina, Advertências)

  • MidazolambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • Mirabegronaagonista beta-adrenérgicoLeve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • OxazepambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • Other Serotonergic Drugs Clinical Impact: Concomitant use of sertraline hydrochloride capsules with other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St. (bula de Sertralina, Interações medicamentosas)

  • PerfenazinaantipsicóticoLeve

    Drug Interactions Metabolism of a number of medications, including antipsychotics, antidepressants, β-blockers, and antiarrhythmics, occurs through the cytochrome P450 2D6 isoenzyme (debrisoquine hydroxylase). (bula de Perfenazina, Interações medicamentosas)

  • PropranololbetabloqueadorLeve

    Antidepressants: The hypotensive effect of MAO inhibitors or tricyclic antidepressants may be exacerbated when administered with beta-blockers. (bula de Propranolol, Interações medicamentosas)

  • Rolapitantoinibidor da CYP2D6Leve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • TerbinafinaantifúngicoLeve

    Drugs Metabolized by CYP2D6 Clinical Impact: Sertraline hydrochloride capsules are a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • TiagabinaanticonvulsivanteLeve

    In most cases, patients were using concomitant medications (antidepressants, antipsychotics, stimulants, narcotics) that are thought to lower the seizure threshold. (bula de Tiagabina, Advertências)

  • It is difficult to determine if Tolcapone tablets played a role in the pathogenesis of these events because these patients received several concomitant medications affecting the central nervous system such as monoaminergic (i.e., MAO-I, tricyclic and selective serotonin reuptake inhibitors) and anticholinergic agents. (bula de Tolcapona, Precauções)

  • TriazolambenzodiazepínicoLeve

    False-Positive Effects on Screening Tests for Benzodiazepines False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking another sertraline hydrochloride product. (bula de Sertralina, Advertências e precauções)

  • TriexifenidilanticolinérgicoLeve

    Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. (bula de Triexifenidil, Interações medicamentosas)

Nenhuma interação significativa relatada (7)

  • AripiprazolantipsicóticoSem interação

    Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when coadministered with ABILIFY MAINTENA. [See Clinical Pharmacology (12.3) ] . (bula de Aripiprazol, Interações medicamentosas)

  • AtenololbetabloqueadorSem interação

    Additionally, no dosage adjustment is required for diazepam, lithium, atenolol, tolbutamide, digoxin, and drugs metabolized by CYP3A4, when sertraline hydrochloride capsules is administered concomitantly [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • Desloratadinaanti-histamínicoSem interação

    …changes in the safety profile of desloratadine. [See Clinical Pharmacology (12.3) .] 7.2 Fluoxetine In controlled clinical studies co-administration of desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes… (bula de Desloratadina, Interações medicamentosas)

  • Digoxinaglicosídeo digitálicoSem interação

    Additionally, no dosage adjustment is required for diazepam, lithium, atenolol, tolbutamide, digoxin, and drugs metabolized by CYP3A4, when sertraline hydrochloride capsules is administered concomitantly [see Clinical Pharmacology ( 12.3 )] . (bula de Sertralina, Interações medicamentosas)

  • EntacaponaSem interação

    No interaction with the tricyclic antidepressant imipramine was shown in a single-dose study with entacapone without coadministered levodopa and dopa-decarboxylase inhibitor. (bula de Entacapona, Precauções)

  • Entricitabina + tenofovirantirretroviralSem interação

    No clinically significant drug interactions have been either observed or are expected when DESCOVY is combined with the following drugs: buprenorphine, itraconazole, ketoconazole, lorazepam, methadone, midazolam, naloxone, norbuprenorphine, norgestimate/ethinyl estradiol, and sertraline. (bula de Entricitabina + tenofovir, Interações medicamentosas)

  • Ropinirolagonista da dopaminaSem interação

    Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (bula de Ropinirol, Interações medicamentosas)

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