ग्रेपफ्रूट (चकोतरा) और निफेडिपिन का इंटरैक्शन

Grapefruit juice should be avoided by patients on nifedipine.

…as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.

Dietary Supplements Grapefruit Juice: In healthy volunteers, a single dose co-administration of 250 mL double strength grapefruit juice with 10 mg nifedipine increased AUC and C max by factors of 1.35 and 1.13, respectively.

Ingestion of repeated doses of grapefruit juice (5 × 200 mL in 12 hours) after administration of 20 mg nifedipine ER increased AUC and C max of nifedipine by a factor of 2.

The intake of grapefruit juice should be stopped at least 3 days prior to initiating patients on nifedipine.

ग्रेपफ्रूट का जूस ब्लड प्रेशर के लिए इस्तेमाल होने वाले कुछ कैल्शियम चैनल ब्लॉकर का खून में स्तर बढ़ा सकता है, जिससे ब्लड प्रेशर ज़रूरत से ज़्यादा गिर सकता है।

लेबल का मूल पाठ (अंग्रेज़ी) Grapefruit juice can raise blood levels of some calcium channel blockers used for blood pressure, which may cause excessive lowering of blood pressure.