Interaksi Grapefruit dan Nifedipin

Grapefruit juice should be avoided by patients on nifedipine.

…as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.

Dietary Supplements Grapefruit Juice: In healthy volunteers, a single dose co-administration of 250 mL double strength grapefruit juice with 10 mg nifedipine increased AUC and C max by factors of 1.35 and 1.13, respectively.

Ingestion of repeated doses of grapefruit juice (5 × 200 mL in 12 hours) after administration of 20 mg nifedipine ER increased AUC and C max of nifedipine by a factor of 2.

The intake of grapefruit juice should be stopped at least 3 days prior to initiating patients on nifedipine.

Jus grapefruit dapat menaikkan kadar dalam darah beberapa penghambat kanal kalsium yang digunakan untuk tekanan darah, yang mungkin menyebabkan penurunan tekanan darah yang berlebihan.

Teks asli label (bahasa Inggris) Grapefruit juice can raise blood levels of some calcium channel blockers used for blood pressure, which may cause excessive lowering of blood pressure.