Wechselwirkungen von Atracurium

Atracurium, ein neuromuskulärer Blocker, hat in den von uns erfassten FDA-Fachinformationen und Faktenblättern 64 dokumentierte Wechselwirkungen: 8 schwerwiegende, 33 mittelschwere, 21 geringfügige und 2, bei denen eine Fachinformation keine relevante Wechselwirkung berichtet. Jeder Eintrag unten zitiert den Satz, auf dem er beruht. Diese Medikamentenseite ist ein Ausgangspunkt, kein Urteil über Ihre persönliche Situation.

Wechselwirkungen laut Fachinformation

Schwerwiegende Wechselwirkungen (8)

  • AlkoholAlkoholSchwerwiegend

    Use of atracurium besylate from multiple dose vials containing benzyl alcohol as a preservative is contraindicated in patients with a known hypersensitivity to benzyl alcohol. (Fachinformation zu Atracurium, Gegenanzeigen)

  • ChininMalariamittelSchwerwiegend

    Avoid concomitant use with neuromuscular blocking agents. (Fachinformation zu Chinin, Warnhinweise und Vorsichtsmaßnahmen)

  • NeomycinAminoglykosidSchwerwiegend

    The possibility of the occurrence of neuromuscular blockage and respiratory paralysis should be considered if neomycin is administered, especially to patients receiving anesthetics, neuromuscular blocking agents such as tubocurarine, succinylcholine, decamethonium, or in patients receiving massive transfusions of citrate anticoagulated blood. (Fachinformation zu Neomycin, Boxed Warning (umrahmter Warnhinweis))

  • PlazomicinAminoglykosidSchwerwiegend

    During therapy with ZEMDRI, monitor for adverse reactions associated with neuromuscular blockade, particularly in high-risk patients, such as patients with underlying neuromuscular disorders (including myasthenia gravis) or in patients concomitantly receiving neuromuscular blocking agents [see Warning and Precautions (5.3) ] . (Fachinformation zu Plazomicin, Boxed Warning (umrahmter Warnhinweis))

  • RemifentanilOpioidSchwerwiegend

    In the case of life-threatening muscle rigidity, a rapid onset neuromuscular blocker or naloxone may be administered. (Fachinformation zu Remifentanil, Warnhinweise und Vorsichtsmaßnahmen)

  • Rocuroniumneuromuskulärer BlockerSchwerwiegend

    Rocuronium Bromide Injection is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents [see Warnings and Precautions ( 5.2 )] . (Fachinformation zu Rocuronium, Gegenanzeigen)

  • SugammadexSchwerwiegend

    Reversal of Neuromuscular Blocking Agents Other Than Rocuronium or Vecuronium Do not use BRIDION to reverse blockade induced by nonsteroidal neuromuscular blocking agents such as succinylcholine or benzylisoquinolinium compounds. (Fachinformation zu Sugammadex, Warnhinweise und Vorsichtsmaßnahmen)

  • Suxamethoniumneuromuskulärer BlockerSchwerwiegend

    Atracurium should not be administered until a patient has recovered from succinylcholine-induced neuromuscular block. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

Mittelschwere Wechselwirkungen (33)

  • AmikacinAminoglykosidMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • BaclofenMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • Botulinumtoxin Typ Aneuromuskulärer BlockerMittelschwer

    Precautions should also be taken in those individuals who have had previous anaphylactic reactions to other neuromuscular blocking agents since cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported in this class of drugs. (Fachinformation zu Atracurium, Warnhinweise)

  • CarisoprodolMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • ChinidinAntiarrhythmikumMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • ChlorzoxazonMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • Cisatracuriumneuromuskulärer BlockerMittelschwer

    Precautions should also be taken in those individuals who have had previous anaphylactic reactions to other neuromuscular blocking agents since cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported in this class of drugs. (Fachinformation zu Atracurium, Warnhinweise)

  • ClindamycinAntibiotikumMittelschwer

    • Neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. (Fachinformation zu Clindamycin, Arzneimittelwechselwirkungen)

  • CyclobenzaprinMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • DantrolenMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • DeflazacortKortikosteroidMittelschwer

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (Fachinformation zu Deflazacort, Warnhinweise und Vorsichtsmaßnahmen)

  • DesfluranAllgemeinanästhetikumMittelschwer

    Neuromuscular Blocking Agents Anesthetic concentrations of desflurane at equilibrium (administered for 15 or more minutes before testing) reduced the ED 95 of succinylcholine by approximately 30% and that of atracurium and pancuronium by approximately 50% compared to N 2 O/opioid anesthesia (see Table 4). (Fachinformation zu Desfluran, Arzneimittelwechselwirkungen)

  • Dextromethorphan und Chinidinserotonerges ArzneimittelMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • FentanylOpioidMittelschwer

    • Risks of Skeletal Muscle Rigidity and Skeletal Muscle Movement : Manage with neuromuscular blocking agent. (Fachinformation zu Fentanyl, Warnhinweise und Vorsichtsmaßnahmen)

  • GentamicinAminoglykosidMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • IncobotulinumtoxinAneuromuskulärer BlockerMittelschwer

    Precautions should also be taken in those individuals who have had previous anaphylactic reactions to other neuromuscular blocking agents since cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported in this class of drugs. (Fachinformation zu Atracurium, Warnhinweise)

  • IsofluranAllgemeinanästhetikumMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • LincomycinAntibiotikumMittelschwer

    Drug Interactions Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents; therefore, it should be used with caution in patients receiving such agents. (Fachinformation zu Lincomycin, Arzneimittelwechselwirkungen)

  • Lithiumserotonerges ArzneimittelMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • MagnesiumVitamine und MineralstoffeMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • MetaxalonMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • MethocarbamolMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • OnabotulinumtoxinAneuromuskulärer BlockerMittelschwer

    Precautions should also be taken in those individuals who have had previous anaphylactic reactions to other neuromuscular blocking agents since cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported in this class of drugs. (Fachinformation zu Atracurium, Warnhinweise)

  • OrphenadrinMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • Piperacillin und TazobactamPenicillin-AntibiotikumMittelschwer

    Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers. (Fachinformation zu Piperacillin und Tazobactam, Arzneimittelwechselwirkungen)

  • ProcainamidAntiarrhythmikumMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • PyridostigminCholinesterasehemmerMittelschwer

    Depolarizing neuromuscular blocking agents: Increased effect. (Fachinformation zu Pyridostigmin, Arzneimittelwechselwirkungen)

  • SevofluranAllgemeinanästhetikumMittelschwer

    When used to supplement alfentanil-N 2 O anesthesia, sevoflurane and isoflurane equally potentiate neuromuscular block induced with pancuronium, vecuronium or atracurium. (Fachinformation zu Sevofluran, Arzneimittelwechselwirkungen)

  • TizanidinMuskelrelaxansMittelschwer

    If other muscle relaxants are used during the same procedure, the possibility of a synergistic or antagonist effect should be considered. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • TobramycinAminoglykosidMittelschwer

    Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. (Fachinformation zu Atracurium, Arzneimittelwechselwirkungen)

  • Vecuroniumneuromuskulärer BlockerMittelschwer

    Precautions should also be taken in those individuals who have had previous anaphylactic reactions to other neuromuscular blocking agents since cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported in this class of drugs. (Fachinformation zu Atracurium, Warnhinweise)

  • VerapamilCalciumkanalblockerMittelschwer

    Neuromuscular Blocking Agents Clinical data and animal studies suggest that verapamil may potentiate the activity of neuromuscular blocking agents (curare-like and depolarizing). (Fachinformation zu Verapamil, Arzneimittelwechselwirkungen)

Geringfügige Erwähnungen (21)

  • Butalbital und ParacetamolBarbituratGeringfügig

    Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • CarbamazepinAntiepileptikumGeringfügig

    N e uromuscular Blocking Agents Resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuronium, vecuronium, rocuronium and cisatracurium has occurred in patients chronically administered carbamazepine. (Fachinformation zu Carbamazepin, Arzneimittelwechselwirkungen)

  • DigoxinDigitalisglykosidGeringfügig

    Norepinephrine Dopamine Neuromuscular Blocking Agents Succinylcholine May cause sudden extrusion of potassium from muscle cells causing arrhythmias in patients taking digoxin. (Fachinformation zu Digoxin, Arzneimittelwechselwirkungen)

  • DonepezilCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

  • DoxapramGeringfügig

    In patients who have received neuromuscular blocking agents, doxapram may temporarily mask the residual effects of these drugs. (Fachinformation zu Doxapram, Arzneimittelwechselwirkungen)

  • FosphenytoinAntiepileptikumGeringfügig

    Neuromuscular blocking agents Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents has occurred in patients chronically administered phenytoin. (Fachinformation zu Fosphenytoin, Arzneimittelwechselwirkungen)

  • GalantaminCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

  • Memantin und DonepezilCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

  • MethohexitalBarbituratGeringfügig

    Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • NeostigminCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

  • PhenobarbitalBarbituratGeringfügig

    Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • PhenytoinAntiepileptikumGeringfügig

    Neuromuscular blocking agents Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents has occurred in patients chronically administered phenytoin. (Fachinformation zu Phenytoin, Arzneimittelwechselwirkungen)

  • PhysostigminCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

  • PrimidonAntiepileptikumGeringfügig

    Atracurium besylate injection, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle. (Fachinformation zu Atracurium, Warnhinweise)

  • PropofolZNS-dämpfendes ArzneimittelGeringfügig

    Common Neuromuscular Blocking Agents DIPRIVAN does not cause a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents (e.g., succinylcholine and nondepolarizing muscle relaxants). (Fachinformation zu Propofol, Arzneimittelwechselwirkungen)

  • RivastigminCholinesterasehemmerGeringfügig

    ANTICHOLINESTERASE REVERSAL AGENTS SHOULD BE IMMEDIATELY AVAILABLE. (Fachinformation zu Atracurium, Warnhinweise)

Keine relevante Wechselwirkung berichtet (2)

  • DexmedetomidinAlpha-Adrenozeptor-AgonistKeine Wechselwirkung

    Neuromuscular Blockers In one study of 10 healthy adult volunteers, administration of PRECEDEX for 45 minutes at a plasma concentration of one ng/mL resulted in no clinically meaningful increases in the magnitude of neuromuscular blockade associated with rocuronium administration. (Fachinformation zu Dexmedetomidin, Arzneimittelwechselwirkungen)

  • OndansetronQT-verlängerndes ArzneimittelKeine Wechselwirkung

    Alfentanil and Atracurium Ondansetron does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracurium. (Fachinformation zu Ondansetron, Arzneimittelwechselwirkungen)

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Im Wechselwirkungscheck öffnen

Keine medizinische Beratung. Der Schweregrad gibt die Formulierung der Fachinformation wieder, nicht Ihre persönlichen Umstände. Eine als „schwerwiegend“ eingestufte Wechselwirkung kann unter Aufsicht Routine sein, und eine „geringfügige“ kann bei hohen Dosen von Bedeutung sein. Fragen Sie in einer Apotheke nach.