Wechselwirkungen von Bexaroten

Bexaroten (Targretin), ein Retinoid, hat in den von uns erfassten FDA-Fachinformationen und Faktenblättern 58 dokumentierte Wechselwirkungen: 5 schwerwiegende, 27 mittelschwere, 26 geringfügige und 0, bei denen eine Fachinformation keine relevante Wechselwirkung berichtet. Jeder Eintrag unten zitiert den Satz, auf dem er beruht. Diese Medikamentenseite ist ein Ausgangspunkt, kein Urteil über Ihre persönliche Situation.

Wechselwirkungen laut Fachinformation

Schwerwiegende Wechselwirkungen (5)

  • AcitretinRetinoidSchwerwiegend

    Acitretin is contraindicated in cases of hypersensitivity (e.g., angioedema, urticaria) to the preparation (acitretin or excipients) or to other retinoids . (Fachinformation zu Acitretin, Gegenanzeigen)

  • GemfibrozilFibratSchwerwiegend

    Because of a potential drug-drug interaction, avoid gemfibrozil use with TARGRETIN [ see Drug Interactions (7) ]. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • MinocyclinTetracyclin-AntibiotikumSchwerwiegend

    Avoid concomitant use of isotretinoin and EMROSI because isotretinoin, a systemic retinoid, is also known to cause idiopathic intracranial hypertension. (Fachinformation zu Minocyclin, Warnhinweise und Vorsichtsmaßnahmen)

  • TetracyclinTetracyclin-AntibiotikumSchwerwiegend

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Fachinformation zu Tetracyclin, Warnhinweise)

  • TretinoinRetinoidSchwerwiegend

    Tretinoin capsules are contraindicated in patients with a known hypersensitivity to tretinoin capsules, any of its components, or other retinoids. (Fachinformation zu Tretinoin, Gegenanzeigen)

Mittelschwere Wechselwirkungen (27)

  • AlkoholAlkoholMittelschwer

    Patients with CTCL who have risk factors for pancreatitis (e.g., prior pancreatitis, uncontrolled hyperlipidemia, excessive alcohol consumption, uncontrolled diabetes mellitus, biliary tract disease, and medications known to increase triglyceride levels or to be associated with pancreatic toxicity) may be at greater risk for pancreatitis associated with TARGRETIN… (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • CalciumchloridMittelschwer

    Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (Fachinformation zu Calciumchlorid, Arzneimittelwechselwirkungen)

  • Patients with elevated vitamin A levels may be at increased risk. (Fachinformation zu Elexacaftor, Tezacaftor und Ivacaftor, Warnhinweise und Vorsichtsmaßnahmen)

  • GlibenclamidSulfonylharnstoffMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Glibenclamid und MetforminSulfonylharnstoffMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • GlimepiridSulfonylharnstoffMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • GlipizidSulfonylharnstoffMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Glipizid und MetforminSulfonylharnstoffMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Humaninsulin (Normalinsulin)InsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Insulin aspartInsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Insulin degludecInsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Insulin detemirInsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Insulin glarginInsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Insulin lisproInsulinMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • IvacaftorCYP3A4-HemmerMittelschwer

    Patients with elevated vitamin A levels may be at increased risk. (Fachinformation zu Ivacaftor, Warnhinweise und Vorsichtsmaßnahmen)

  • LevothyroxinSchilddrüsenhormonMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Levothyroxin und LiothyroninSchilddrüsenhormonMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • LiothyroninSchilddrüsenhormonMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • MethotrexatImmunsuppressivumMittelschwer

    Monitor patients receiving XATMEP with other potential hepatotoxins (e.g., azathioprine, retinoids, and sulfasalazine) for possible signs of hepatotoxicity. (Fachinformation zu Methotrexat, Arzneimittelwechselwirkungen)

  • OrlistatMittelschwer

    The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (Fachinformation zu Orlistat, Arzneimittelwechselwirkungen)

  • PioglitazonThiazolidindion (Glitazon)Mittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Pioglitazon und GlimepiridThiazolidindion (Glitazon)Mittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • Pioglitazon und MetforminThiazolidindion (Glitazon)Mittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • PropylthiouracilThyreostatikumMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • TeriparatidSchilddrüsenhormonMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • ThiamazolThyreostatikumMittelschwer

    Monitor and replace thyroid hormone if needed. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • TirzepatidGLP-1-RezeptoragonistMittelschwer

    Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

Geringfügige Erwähnungen (26)

  • Amlodipin und AtorvastatinDihydropyridin-CalciumkanalblockerGeringfügig

    Atorvastatin was used in 48% (73/152) of patients with CTCL. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • AtorvastatinStatinGeringfügig

    Atorvastatin was used in 48% (73/152) of patients with CTCL. (Fachinformation zu Bexaroten, Warnhinweise und Vorsichtsmaßnahmen)

  • CalciumgluconatGeringfügig

    Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (Fachinformation zu Calciumgluconat, Arzneimittelwechselwirkungen)

  • Desogestrel und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Drospirenon und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • EstradiolEstrogenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Estradiol und Dienogestorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Estradiol und NorethisteronEstrogenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Etynodioldiacetat und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • FluconazolAzol-AntimykotikumGeringfügig

    Vitamin A Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of fluconazole treatment. (Fachinformation zu Fluconazol, Arzneimittelwechselwirkungen)

  • FulvestrantEstrogenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Konjugierte EstrogeneEstrogenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • LevonorgestrelGestagenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Levonorgestrel und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • MedroxyprogesteronGestagenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • MegestrolGestagenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • MifepristonCYP3A4-HemmerGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • NorethisteronGestagenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Norethisteron und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Norgestimat und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Norgestrel und Ethinylestradiolorales KontrazeptivumGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • ProgesteronGestagenGeringfügig

    Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

  • Drug products which may be affected include oral or other systemic hormonal contraceptives. (Fachinformation zu Bexaroten, Arzneimittelwechselwirkungen)

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Im Wechselwirkungscheck öffnen

Keine medizinische Beratung. Der Schweregrad gibt die Formulierung der Fachinformation wieder, nicht Ihre persönlichen Umstände. Eine als „schwerwiegend“ eingestufte Wechselwirkung kann unter Aufsicht Routine sein, und eine „geringfügige“ kann bei hohen Dosen von Bedeutung sein. Fragen Sie in einer Apotheke nach.