Wechselwirkungen von Phentolamin

Phentolamin (OraVerse, Regitine), ein Alphablocker, hat in den von uns erfassten FDA-Fachinformationen und Faktenblättern 47 dokumentierte Wechselwirkungen: 8 schwerwiegende, 28 mittelschwere, 10 geringfügige und 1, bei denen eine Fachinformation keine relevante Wechselwirkung berichtet. Jeder Eintrag unten zitiert den Satz, auf dem er beruht. Diese Medikamentenseite ist ein Ausgangspunkt, kein Urteil über Ihre persönliche Situation.

Wechselwirkungen laut Fachinformation

Schwerwiegende Wechselwirkungen (8)

  • AlfuzosinAlphablockerSchwerwiegend

    Should not be used in combination with other alpha adrenergic antagonists ( 5.4 , 7.2 ) (Fachinformation zu Alfuzosin, Warnhinweise und Vorsichtsmaßnahmen)

  • Dutasterid und Tamsulosin5-Alpha-ReduktasehemmerSchwerwiegend

    Do not use JALYN with other alpha-adrenergic antagonists, as this may increase the risk of hypotension. (Fachinformation zu Dutasterid und Tamsulosin, Warnhinweise und Vorsichtsmaßnahmen)

  • IloperidonAntipsychotikumSchwerwiegend

    Avoid coadministration of FANAPT with alpha-adrenergic blocking agents and adjust medications that affect blood pressure as needed [see Warnings and Precautions (5.7) ] . (Fachinformation zu Iloperidon, Arzneimittelwechselwirkungen)

  • ItraconazolAzol-AntimykotikumSchwerwiegend

    …that Affect Concomitant Drug Concentrations Concomitant Drug Within Class Prevention or Management Drug Interactions with TOLSURA that Increase Concomitant Drug Concentrations and May Increase Risk of Adverse Reactions Associated with the Concomitant Drug Alpha Blockers Alfuzosin Silodosin Tamsulosin Not recommended during and 2 weeks after TOLSURA treatment. (Fachinformation zu Itraconazol, Arzneimittelwechselwirkungen)

  • PhenelzinMAO-HemmerSchwerwiegend

    (The dosage reported for phentolamine is 5 mg intravenously.) Care should be taken to administer this drug slowly in order to avoid producing an excessive hypotensive effect. (Fachinformation zu Phenelzin, Warnhinweise)

  • SilodosinAlphablockerSchwerwiegend

    Silodosin capsules should not be used in combination with other alpha-blockers. (Fachinformation zu Silodosin, Warnhinweise und Vorsichtsmaßnahmen)

  • TadalafilPDE-5-HemmerSchwerwiegend

    CIALIS is not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. (Fachinformation zu Tadalafil, Warnhinweise und Vorsichtsmaßnahmen)

  • TamsulosinAlphablockerSchwerwiegend

    • Should not be used in combination with other alpha adrenergic blocking agents ( 5.2 , 7.2 , 12.3 ) (Fachinformation zu Tamsulosin, Warnhinweise und Vorsichtsmaßnahmen)

Mittelschwere Wechselwirkungen (28)

  • AdrenalinSympathomimetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • Articain und AdrenalinLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • AvanafilPDE-5-HemmerMittelschwer

    • Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (Fachinformation zu Avanafil, Warnhinweise und Vorsichtsmaßnahmen)

  • BupivacainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • Bupivacain und AdrenalinLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • ChloroprocainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • DesfluranAllgemeinanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • DoxazosinAlphablockerMittelschwer

    As with other alpha-blockers, there is a potential for syncope, especially after the initial dose or after an increase in dosage strength. (Fachinformation zu Doxazosin, Warnhinweise und Vorsichtsmaßnahmen)

  • EtomidatAllgemeinanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • GlucagonMittelschwer

    If the patient develops a substantial increase in blood pressure and a previously undiagnosed pheochromocytoma is suspected, 5 to 10 mg of phentolamine mesylate, administered intravenously, has been shown to be effective in lowering blood pressure. (Fachinformation zu Glucagon, Warnhinweise und Vorsichtsmaßnahmen)

  • IsofluranAllgemeinanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • KetaminZNS-dämpfendes ArzneimittelMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • KetoconazolAzol-AntimykotikumMittelschwer

    Alpha Blockers tamsulosin Analgesics methadone alfentanil, buprenorphine IV and sublingual, fentanyl, oxycodone, sufentanil Methadone: The potential increase in plasma concentrations of methadone when coadministered with ketoconazole tablets may increase the risk of serious cardiovascular events including QT prolongation and torsade de pointes, or respiratory… (Fachinformation zu Ketoconazol, Arzneimittelwechselwirkungen)

  • KokainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • LidocainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • Lidocain und AdrenalinLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • Lidocain und PrilocainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • MepivacainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • MethohexitalBarbituratMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • MetirosinMittelschwer

    Intraoperative Effects While the preoperative use of metyrosine capsules in patients with pheochromocytoma is thought to decrease intraoperative problems with blood pressure control, metyrosine does not eliminate the danger of hypertensive crises or arrhythmias during manipulation of the tumor, and the alpha-adrenergic blocking drug, phentolamine, may be needed. (Fachinformation zu Metirosin, Warnhinweise)

  • NifedipinDihydropyridin-CalciumkanalblockerMittelschwer

    Central Alpha1-Blockers Doxazosin: Healthy volunteers participating in a multiple dose doxazosin-nifedipine interaction study received 2 mg doxazosin q.d. alone or combined with 20 mg nifedipine ER b.i.d. Co-administration of nifedipine resulted in a decrease in AUC and C max of doxazosin to 83% and 86% of the values in the absence of nifedipine, respectively. (Fachinformation zu Nifedipin, Arzneimittelwechselwirkungen)

  • Prilocain und AdrenalinLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • PropofolZNS-dämpfendes ArzneimittelMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • PropranololBetablockerMittelschwer

    Alpha Blockers: Co-administration of beta-blockers with alpha-blocker (e.g., prazosin) has been associated with prolongation of first dose hypotension and syncope. (Fachinformation zu Propranolol, Arzneimittelwechselwirkungen)

  • RopivacainLokalanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • SevofluranAllgemeinanästhetikumMittelschwer

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (Fachinformation zu Phentolamin, Arzneimittelwechselwirkungen)

  • SildenafilPDE-5-HemmerMittelschwer

    Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (Fachinformation zu Sildenafil, Warnhinweise und Vorsichtsmaßnahmen)

  • VardenafilPDE-5-HemmerMittelschwer

    Alpha-Blockers : Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. (Fachinformation zu Vardenafil, Warnhinweise und Vorsichtsmaßnahmen)

Geringfügige Erwähnungen (10)

  • CarvedilolBetablockerGeringfügig

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (Fachinformation zu Phentolamin, Warnhinweise und Vorsichtsmaßnahmen)

  • ClonidinAlpha-Adrenozeptor-AgonistGeringfügig

    If rebound hypertension occurs, reverse hypertensive crisis with oral clonidine or IV phentolamine. (Fachinformation zu Clonidin, Warnhinweise und Vorsichtsmaßnahmen)

  • EsmololBetablockerGeringfügig

    Use in Patients with Pheochromocytoma If BREVIBLOC injection is used in the setting of pheochromocytoma, give it in combination with an alpha-blocker, and only after the alpha-blocker has been initiated. (Fachinformation zu Esmolol, Warnhinweise und Vorsichtsmaßnahmen)

  • LabetalolBetablockerGeringfügig

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (Fachinformation zu Phentolamin, Warnhinweise und Vorsichtsmaßnahmen)

  • MetoprololBetablockerGeringfügig

    Pheochromocytoma: Initiate therapy with an alpha blocker. (Fachinformation zu Metoprolol, Warnhinweise und Vorsichtsmaßnahmen)

  • Metoprolol und HydrochlorothiazidBetablockerGeringfügig

    Pheochromocytoma: First initiate therapy with an alpha blocker. (Fachinformation zu Metoprolol und Hydrochlorothiazid, Warnhinweise und Vorsichtsmaßnahmen)

  • MidodrinAlpha-Adrenozeptor-AgonistGeringfügig

    Alpha-adrenergic blocking agents, such as prazosin, terazosin, and doxazosin, can antagonize the effects of midodrine hydrochloride. (Fachinformation zu Midodrin, Arzneimittelwechselwirkungen)

  • PhenoxybenzaminAlphablockerGeringfügig

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (Fachinformation zu Phentolamin, Warnhinweise und Vorsichtsmaßnahmen)

  • PrazosinAlphablockerGeringfügig

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (Fachinformation zu Phentolamin, Warnhinweise und Vorsichtsmaßnahmen)

  • TerazosinAlphablockerGeringfügig

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (Fachinformation zu Phentolamin, Warnhinweise und Vorsichtsmaßnahmen)

Keine relevante Wechselwirkung berichtet (1)

  • Dutasterid5-Alpha-ReduktasehemmerKeine Wechselwirkung

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (Fachinformation zu Dutasterid, Arzneimittelwechselwirkungen)

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Im Wechselwirkungscheck öffnen

Keine medizinische Beratung. Der Schweregrad gibt die Formulierung der Fachinformation wieder, nicht Ihre persönlichen Umstände. Eine als „schwerwiegend“ eingestufte Wechselwirkung kann unter Aufsicht Routine sein, und eine „geringfügige“ kann bei hohen Dosen von Bedeutung sein. Fragen Sie in einer Apotheke nach.