Interações de Fentolamina

Fentolamina (OraVerse, Regitine), alfabloqueador, tem 47 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 8; moderadas: 28; leves: 10; casos em que uma bula relata não haver interação significativa: 1). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (8)

  • AlfuzosinaalfabloqueadorGrave

    Should not be used in combination with other alpha adrenergic antagonists ( 5.4 , 7.2 ) (bula de Alfuzosina, Advertências e precauções)

  • Dutasterida + tansulosinainibidor da 5-alfa-redutaseGrave

    Do not use JALYN with other alpha-adrenergic antagonists, as this may increase the risk of hypotension. (bula de Dutasterida + tansulosina, Advertências e precauções)

  • Fenelzinainibidor da MAOGrave

    (The dosage reported for phentolamine is 5 mg intravenously.) Care should be taken to administer this drug slowly in order to avoid producing an excessive hypotensive effect. (bula de Fenelzina, Advertências)

  • IloperidonaantipsicóticoGrave

    Avoid coadministration of FANAPT with alpha-adrenergic blocking agents and adjust medications that affect blood pressure as needed [see Warnings and Precautions (5.7) ] . (bula de Iloperidona, Interações medicamentosas)

  • Itraconazolantifúngico azólicoGrave

    …that Affect Concomitant Drug Concentrations Concomitant Drug Within Class Prevention or Management Drug Interactions with TOLSURA that Increase Concomitant Drug Concentrations and May Increase Risk of Adverse Reactions Associated with the Concomitant Drug Alpha Blockers Alfuzosin Silodosin Tamsulosin Not recommended during and 2 weeks after TOLSURA treatment. (bula de Itraconazol, Interações medicamentosas)

  • SilodosinaalfabloqueadorGrave

    Silodosin capsules should not be used in combination with other alpha-blockers. (bula de Silodosina, Advertências e precauções)

  • Tadalafilainibidor da PDE5Grave

    CIALIS is not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. (bula de Tadalafila, Advertências e precauções)

  • TansulosinaalfabloqueadorGrave

    • Should not be used in combination with other alpha adrenergic blocking agents ( 5.2 , 7.2 , 12.3 ) (bula de Tansulosina, Advertências e precauções)

Interações moderadas (28)

  • Articaína + epinefrinaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Avanafilainibidor da PDE5Moderada

    • Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (bula de Avanafila, Advertências e precauções)

  • Bupivacaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Bupivacaína + epinefrinaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Cetaminadepressor do SNCModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Cetoconazolantifúngico azólicoModerada

    Alpha Blockers tamsulosin Analgesics methadone alfentanil, buprenorphine IV and sublingual, fentanyl, oxycodone, sufentanil Methadone: The potential increase in plasma concentrations of methadone when coadministered with ketoconazole tablets may increase the risk of serious cardiovascular events including QT prolongation and torsade de pointes, or respiratory… (bula de Cetoconazol, Interações medicamentosas)

  • Cloroprocaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Cocaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Desfluranoanestésico geralModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • DoxazosinaalfabloqueadorModerada

    As with other alpha-blockers, there is a potential for syncope, especially after the initial dose or after an increase in dosage strength. (bula de Doxazosina, Advertências e precauções)

  • Epinefrina (adrenalina)simpaticomiméticoModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Etomidatoanestésico geralModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • GlucagonModerada

    If the patient develops a substantial increase in blood pressure and a previously undiagnosed pheochromocytoma is suspected, 5 to 10 mg of phentolamine mesylate, administered intravenously, has been shown to be effective in lowering blood pressure. (bula de Glucagon, Advertências e precauções)

  • Isofluranoanestésico geralModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Lidocaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Lidocaína + epinefrinaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Lidocaína + prilocaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Mepivacaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • MetirosinaModerada

    Intraoperative Effects While the preoperative use of metyrosine capsules in patients with pheochromocytoma is thought to decrease intraoperative problems with blood pressure control, metyrosine does not eliminate the danger of hypertensive crises or arrhythmias during manipulation of the tumor, and the alpha-adrenergic blocking drug, phentolamine, may be needed. (bula de Metirosina, Advertências)

  • MetoexitalbarbitúricoModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Nifedipinobloqueador dos canais de cálcio di-hidropiridínicoModerada

    Central Alpha1-Blockers Doxazosin: Healthy volunteers participating in a multiple dose doxazosin-nifedipine interaction study received 2 mg doxazosin q.d. alone or combined with 20 mg nifedipine ER b.i.d. Co-administration of nifedipine resulted in a decrease in AUC and C max of doxazosin to 83% and 86% of the values in the absence of nifedipine, respectively. (bula de Nifedipino, Interações medicamentosas)

  • Prilocaína + epinefrinaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Propofoldepressor do SNCModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • PropranololbetabloqueadorModerada

    Alpha Blockers: Co-administration of beta-blockers with alpha-blocker (e.g., prazosin) has been associated with prolongation of first dose hypotension and syncope. (bula de Propranolol, Interações medicamentosas)

  • Ropivacaínaanestésico localModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Sevofluranoanestésico geralModerada

    Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection. (bula de Fentolamina, Interações medicamentosas)

  • Sildenafilainibidor da PDE5Moderada

    Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (bula de Sildenafila, Advertências e precauções)

  • Vardenafilainibidor da PDE5Moderada

    Alpha-Blockers : Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. (bula de Vardenafila, Advertências e precauções)

Menções leves (10)

  • CarvedilolbetabloqueadorLeve

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (bula de Fentolamina, Advertências e precauções)

  • Clonidinaagonista alfa-adrenérgicoLeve

    If rebound hypertension occurs, reverse hypertensive crisis with oral clonidine or IV phentolamine. (bula de Clonidina, Advertências e precauções)

  • EsmololbetabloqueadorLeve

    Use in Patients with Pheochromocytoma If BREVIBLOC injection is used in the setting of pheochromocytoma, give it in combination with an alpha-blocker, and only after the alpha-blocker has been initiated. (bula de Esmolol, Advertências e precauções)

  • FenoxibenzaminaalfabloqueadorLeve

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (bula de Fentolamina, Advertências e precauções)

  • LabetalolbetabloqueadorLeve

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (bula de Fentolamina, Advertências e precauções)

  • MetoprololbetabloqueadorLeve

    Pheochromocytoma: Initiate therapy with an alpha blocker. (bula de Metoprolol, Advertências e precauções)

  • Pheochromocytoma: First initiate therapy with an alpha blocker. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)

  • Midodrinaagonista alfa-adrenérgicoLeve

    Alpha-adrenergic blocking agents, such as prazosin, terazosin, and doxazosin, can antagonize the effects of midodrine hydrochloride. (bula de Midodrina, Interações medicamentosas)

  • PrazosinaalfabloqueadorLeve

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (bula de Fentolamina, Advertências e precauções)

  • TerazosinaalfabloqueadorLeve

    Tachycardia and cardiac arrhythmiasmay occur with the use of phentolamine or other alpha-adrenergic blocking agents. (bula de Fentolamina, Advertências e precauções)

Nenhuma interação significativa relatada (1)

  • Dutasteridainibidor da 5-alfa-redutaseSem interação

    Alpha-adrenergic Antagonists The administration of dutasteride capsules in combination with tamsulosin or terazosin has no effect on the steady-state pharmacokinetics of either alpha-adrenergic antagonist. (bula de Dutasterida, Interações medicamentosas)

Verifique Fentolamina com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.