Dinitrate d'isosorbide : interactions médicamenteuses

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Hypersensitivity to Nitroglycerin Lingual Spray or to other nitrates or nitrites or any excipient. (notice Trinitrine, Contre-indications)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (notice Dinitrate d'isosorbide, Contre-indications)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (notice Adénosine, Mises en garde et précautions)

Alcohol, in particular, has been found to exhibit additive effects of this variety. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (notice Alfuzosine, Mises en garde et précautions)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (notice Amlodipine et valsartan, Mises en garde et précautions)

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics… (notice Articaïne et adrénaline, Interactions médicamenteuses)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (notice Bupivacaïne, Interactions médicamenteuses)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (notice Bupivacaïne et adrénaline, Interactions médicamenteuses)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (notice Captopril, Précautions)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (notice Chloroprocaïne, Précautions)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (notice Dexmédétomidine, Mises en garde et précautions)

…drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (notice Dicyclovérine, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

…oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular organic cation transport, and QTc-prolonging drugs. (notice Dofétilide, Interactions médicamenteuses)

Most cases reported product application with use under occlusion, genital application, or application to a large body surface area which may increase the systemic absorption of econazole nitrate. (notice Éconazole, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Co-administration of vaginal miconazole nitrate and Etonogestrel/Ethinyl Estradiol Vaginal Ring increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40% [see Clinical Pharmacology (12.3) ] . (notice Étonogestrel et éthinylestradiol, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (notice Lidocaïne et adrénaline, Interactions médicamenteuses)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (notice Lidocaïne et prilocaïne, Interactions médicamenteuses)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitroglycerin, nitroprusside, nitric oxide, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (notice Mépivacaïne, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Caution should also be used when niacin extended-release tablets are used in patients with unstable angina or in the acute phase of an MI, particularly when such patients are also receiving vasoactive drugs such as nitrates, calcium channel blockers, or adrenergic blocking agents. (notice Niacine, Mises en garde et précautions)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (notice Nifédipine, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: EXAMPLES OF DRUGS ASSOCIATED WITH METHEMOGLOBINEMIA: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (notice Prilocaïne et adrénaline, Interactions médicamenteuses)

…exposed to the following drugs, which could include other local anesthetics [see Warnings and Precautions ( 5.4 )] : Examples of Drugs Associated with Methemoglobinemia Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (notice Ropivacaïne, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (notice Vérapamil, Interactions médicamenteuses)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (notice Dinitrate d'isosorbide, Interactions médicamenteuses)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (notice Adrénaline, Interactions médicamenteuses)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (notice Dobutamine, Interactions médicamenteuses)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (notice Dutastéride et tamsulosine, Mises en garde et précautions)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (notice Énalapril et hydrochlorothiazide, Interactions médicamenteuses)

Other Cardiovascular Agents Enalaprilat injection, USP has been used concomitantly with digitalis, beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (notice Énalaprilate, Interactions médicamenteuses)

…acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives without evidence of clinically… (notice Finastéride, Interactions médicamenteuses)

Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant adverse interactions. (notice Lisinopril et hydrochlorothiazide, Interactions médicamenteuses)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (notice Méthohexital, Mises en garde)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (notice Silodosine, Mises en garde et précautions)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (notice Tamsulosine, Mises en garde et précautions)

Drug Interactions with Amlodipine In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. (notice Telmisartan et amlodipine, Interactions médicamenteuses)