تداخلات إيزوسوربيد ثنائي النترات

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (نشرة إيزوسوربيد ثنائي النترات، موانع الاستعمال)

Hypersensitivity to Nitroglycerin Lingual Spray or to other nitrates or nitrites or any excipient. (نشرة نيتروغليسرين، موانع الاستعمال)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (نشرة أدينوزين، التحذيرات والاحتياطات)

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics… (نشرة أرتيكايين وأدرينالين، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (نشرة ألفوزوسين، التحذيرات والاحتياطات)

Alcohol, in particular, has been found to exhibit additive effects of this variety. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (نشرة أملوديبين وفالسارتان، التحذيرات والاحتياطات)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Co-administration of vaginal miconazole nitrate and Etonogestrel/Ethinyl Estradiol Vaginal Ring increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40% [see Clinical Pharmacology (12.3) ] . (نشرة إيتونوجيستريل وإيثينيل إستراديول، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Most cases reported product application with use under occlusion, genital application, or application to a large body surface area which may increase the systemic absorption of econazole nitrate. (نشرة إيكونازول، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: EXAMPLES OF DRUGS ASSOCIATED WITH METHEMOGLOBINEMIA: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (نشرة بريلوكايين وأدرينالين، التداخلات الدوائية)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (نشرة بوبيفاكايين، التداخلات الدوائية)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (نشرة بوبيفاكايين وأدرينالين، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

…oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular organic cation transport, and QTc-prolonging drugs. (نشرة دوفيتيليد، التداخلات الدوائية)

…drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (نشرة ديسيكلومين، التداخلات الدوائية)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (نشرة ديكسميديتوميدين، التحذيرات والاحتياطات)

…exposed to the following drugs, which could include other local anesthetics [see Warnings and Precautions ( 5.4 )] : Examples of Drugs Associated with Methemoglobinemia Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (نشرة روبيفاكايين، التداخلات الدوائية)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (نشرة فيراباميل، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (نشرة كابتوبريل، الاحتياطات)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (نشرة كلوروبروكايين، الاحتياطات)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (نشرة ليدوكايين وأدرينالين، التداخلات الدوائية)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (نشرة ليدوكايين وبريلوكايين، التداخلات الدوائية)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitroglycerin, nitroprusside, nitric oxide, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (نشرة ميبيفاكايين، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Caution should also be used when niacin extended-release tablets are used in patients with unstable angina or in the acute phase of an MI, particularly when such patients are also receiving vasoactive drugs such as nitrates, calcium channel blockers, or adrenergic blocking agents. (نشرة نياسين، التحذيرات والاحتياطات)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (نشرة نيفيديبين، التداخلات الدوائية)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (نشرة إيزوسوربيد ثنائي النترات، التداخلات الدوائية)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (نشرة أدرينالين، التداخلات الدوائية)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Other Cardiovascular Agents Enalaprilat injection, USP has been used concomitantly with digitalis, beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريلات، التداخلات الدوائية)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (نشرة تامسولوسين، التحذيرات والاحتياطات)

Drug Interactions with Amlodipine In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. (نشرة تيلميسارتان وأملوديبين، التداخلات الدوائية)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (نشرة دوبوتامين، التداخلات الدوائية)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (نشرة دوتاستيريد وتامسولوسين، التحذيرات والاحتياطات)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (نشرة سيلودوسين، التحذيرات والاحتياطات)

…acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives without evidence of clinically… (نشرة فيناستيريد، التداخلات الدوائية)

Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant adverse interactions. (نشرة ليزينوبريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (نشرة ميثوهيكسيتال، التحذيرات)