Wechselwirkungen von Isosorbiddinitrat

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Hypersensitivity to Nitroglycerin Lingual Spray or to other nitrates or nitrites or any excipient. (Fachinformation zu Glyceroltrinitrat (Nitroglycerin), Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. (Fachinformation zu Isosorbiddinitrat, Gegenanzeigen)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (Fachinformation zu Adenosin, Warnhinweise und Vorsichtsmaßnahmen)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (Fachinformation zu Alfuzosin, Warnhinweise und Vorsichtsmaßnahmen)

Alcohol, in particular, has been found to exhibit additive effects of this variety. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (Fachinformation zu Amlodipin und Valsartan, Warnhinweise und Vorsichtsmaßnahmen)

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics… (Fachinformation zu Articain und Adrenalin, Arzneimittelwechselwirkungen)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Bupivacain, Arzneimittelwechselwirkungen)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Bupivacain und Adrenalin, Arzneimittelwechselwirkungen)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (Fachinformation zu Captopril, Vorsichtsmaßnahmen)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (Fachinformation zu Chloroprocain, Vorsichtsmaßnahmen)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (Fachinformation zu Dexmedetomidin, Warnhinweise und Vorsichtsmaßnahmen)

…drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (Fachinformation zu Dicycloverin, Arzneimittelwechselwirkungen)

…oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular organic cation transport, and QTc-prolonging drugs. (Fachinformation zu Dofetilid, Arzneimittelwechselwirkungen)

Most cases reported product application with use under occlusion, genital application, or application to a large body surface area which may increase the systemic absorption of econazole nitrate. (Fachinformation zu Econazol, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Co-administration of vaginal miconazole nitrate and Etonogestrel/Ethinyl Estradiol Vaginal Ring increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40% [see Clinical Pharmacology (12.3) ] . (Fachinformation zu Etonogestrel und Ethinylestradiol, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Lidocain und Adrenalin, Arzneimittelwechselwirkungen)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (Fachinformation zu Lidocain und Prilocain, Arzneimittelwechselwirkungen)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitroglycerin, nitroprusside, nitric oxide, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (Fachinformation zu Mepivacain, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Caution should also be used when niacin extended-release tablets are used in patients with unstable angina or in the acute phase of an MI, particularly when such patients are also receiving vasoactive drugs such as nitrates, calcium channel blockers, or adrenergic blocking agents. (Fachinformation zu Nicotinsäure (Niacin), Warnhinweise und Vorsichtsmaßnahmen)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (Fachinformation zu Nifedipin, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

…methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: EXAMPLES OF DRUGS ASSOCIATED WITH METHEMOGLOBINEMIA: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (Fachinformation zu Prilocain und Adrenalin, Arzneimittelwechselwirkungen)

…exposed to the following drugs, which could include other local anesthetics [see Warnings and Precautions ( 5.4 )] : Examples of Drugs Associated with Methemoglobinemia Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine,… (Fachinformation zu Ropivacain, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (Fachinformation zu Verapamil, Arzneimittelwechselwirkungen)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Fachinformation zu Isosorbiddinitrat, Arzneimittelwechselwirkungen)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (Fachinformation zu Adrenalin, Arzneimittelwechselwirkungen)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (Fachinformation zu Dobutamin, Arzneimittelwechselwirkungen)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (Fachinformation zu Dutasterid und Tamsulosin, Warnhinweise und Vorsichtsmaßnahmen)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (Fachinformation zu Enalapril und Hydrochlorothiazid, Arzneimittelwechselwirkungen)

Other Cardiovascular Agents Enalaprilat injection, USP has been used concomitantly with digitalis, beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (Fachinformation zu Enalaprilat, Arzneimittelwechselwirkungen)

…acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H 2 antagonists and quinolone anti-infectives without evidence of clinically… (Fachinformation zu Finasterid, Arzneimittelwechselwirkungen)

Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant adverse interactions. (Fachinformation zu Lisinopril und Hydrochlorothiazid, Arzneimittelwechselwirkungen)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (Fachinformation zu Methohexital, Warnhinweise)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (Fachinformation zu Silodosin, Warnhinweise und Vorsichtsmaßnahmen)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (Fachinformation zu Tamsulosin, Warnhinweise und Vorsichtsmaßnahmen)

Drug Interactions with Amlodipine In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. (Fachinformation zu Telmisartan und Amlodipin, Arzneimittelwechselwirkungen)