ग्रेपफ्रूट (चकोतरा) के इंटरैक्शन

Avoid food or drink containing grapefruit. (आइवाकैफ्टर लेबल, दवाओं के इंटरैक्शन)

Grapefruit juice may also increase plasma concentrations of imatinib; avoid grapefruit juice [see Clinical Pharmacology (12.3)] . (इमैटिनिब लेबल, दवाओं के इंटरैक्शन)

Food or drink containing grapefruit should be avoided during treatment with RINVOQ/RINVOQ LQ. (उपाडासिटिनिब लेबल, दवाओं के इंटरैक्शन)

Grapefruit or grapefruit juice may also increase axitinib plasma concentrations and should be avoided. (एक्सिटिनिब लेबल, दवाओं के इंटरैक्शन)

Intervention: Avoid grapefruit juice when taking VYTORIN. (एज़ेटिमाइब और सिमवास्टेटिन लेबल, दवाओं के इंटरैक्शन)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking LIPITOR [see Drug Interactions (7.1) ] . (एटोरवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking amlodipine and atorvastatin tablets [see Drug Interactions (7.3) ]. (एम्लोडिपिन और एटोरवास्टेटिन लेबल, चेतावनियां और सावधानियां)

Avoid co-administering erlotinib with strong CYP3A4 inhibitors (e.g., boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole, grapefruit or grapefruit juice) or a combined CYP3A4 and CYP1A2 inhibitor (e.g., ciprofloxacin). (एर्लोटिनिब लेबल, दवाओं के इंटरैक्शन)

Avoid food or drink containing grapefruit. (एलेक्साकैफ्टर, टेज़ाकैफ्टर और आइवाकैफ्टर लेबल, दवाओं के इंटरैक्शन)

Avoid ingestion of foods (e.g., grapefruit, grapefruit juice) or nutritional supplements that are known to inhibit cytochrome P450 while taking COMETRIQ. (कैबोज़ैंटिनिब लेबल, दवाओं के इंटरैक्शन)

CYP3A4 The concomitant use of colchicine capsules and CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil, etc.) should be avoided due to the potential for serious and life-threatening toxicity [see Warnings and Precautions (5.3) and Clinical Pharmacology (12) ] . (कोल्चिसिन लेबल, दवाओं के इंटरैक्शन)

Although the clinical significance of this interaction is unknown, grapefruit juice should be avoided. (क्विनिडिन लेबल, दवाओं के इंटरैक्शन)

Avoid grapefruit or grapefruit juice. (टैक्रोलिमस लेबल, दवाओं के इंटरैक्शन)

Grapefruit juice may also increase plasma concentrations of toremifene and should be avoided. (टोरेमिफेन लेबल, दवाओं के इंटरैक्शन)

Patients should avoid grapefruit juice beverages while taking SAMSCA [see Clinical Pharmacology (12.3) ] . (टोल्वैप्टन लेबल, दवाओं के इंटरैक्शन)

• Grapefruit juice: Avoid concomitant use. (ड्रोनेडेरोन लेबल, दवाओं के इंटरैक्शन)

•Avoid consumption of grapefruit or grapefruit juice during treatment with MOVANTIK [see Dosage and Administration (2.1) ] . (नालोक्सेगोल लेबल, दवाओं के इंटरैक्शन)

Grapefruit juice should be avoided by patients on nifedipine. (निफेडिपिन लेबल, सावधानियां)

Avoid grapefruit juice. (निमोडिपिन लेबल, दवाओं के इंटरैक्शन)

Avoid grapefruit or grapefruit juice during IBRANCE treatment. (पाल्बोसिक्लिब लेबल, दवाओं के इंटरैक्शन)

Interaction with Food Patients should avoid grapefruit juice because it may inhibit the metabolism of pimozide by CYP 3A4. (पिमोज़ाइड लेबल, दवाओं के इंटरैक्शन)

Patients receiving buspirone should be advised to avoid drinking such large amounts of grapefruit juice. (बस्पिरोन लेबल, दवाओं के इंटरैक्शन)

Avoid coadministration of VITRAKVI with strong CYP3A4 inhibitors, including grapefruit or grapefruit juice. (लैरोट्रेक्टिनिब लेबल, दवाओं के इंटरैक्शन)

Patients must avoid grapefruit juice ( 4 , 5.6 , 7.1 ). (लोमिटापाइड लेबल, दवाओं के इंटरैक्शन)

…products Gemfibrozil Avoid with lovastatin Cyclosporine Danazol Do not exceed 20 mg lovastatin daily Diltiazem Dronedarone Verapamil Amiodarone Do not exceed 40 mg lovastatin daily Grapefruit juice Avoid grapefruit juice Immune-Mediated Necrotizing Myopathy There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated… (लोवास्टेटिन लेबल, चेतावनियां)

Grapefruit Juice Grapefruit and grapefruit juice affect metabolism, increasing blood concentrations of cyclosporine, thus should be avoided. (साइक्लोस्पोरिन लेबल, दवाओं के इंटरैक्शन)

Intervention: Avoid grapefruit juice when taking ZOCOR. (सिमवास्टेटिन लेबल, दवाओं के इंटरैक्शन)

Grapefruit Juice Because grapefruit juice inhibits the CYP3A4-mediated metabolism of sirolimus, it must not be taken with sirolimus [ see Clinical Pharmacology (12.3) ]. (सिरोलिमस लेबल, दवाओं के इंटरैक्शन)

Avoid food or drink containing grapefruit. (सुज़ेट्रिजिन लेबल, दवाओं के इंटरैक्शन)

Examples of moderate CYP3A4 inhibitors include diltiazem, verapamil, and grapefruit juice [ s ee Warnings and Precautions ( 5.3 ) and Clinical Pharmacology ( 12.3 )] . (आइवाब्राडिन लेबल, दवाओं के इंटरैक्शन)

ग्रेपफ्रूट का जूस ब्लड प्रेशर के लिए इस्तेमाल होने वाले कुछ कैल्शियम चैनल ब्लॉकर का खून में स्तर बढ़ा सकता है, जिससे ब्लड प्रेशर ज़रूरत से ज़्यादा गिर सकता है। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Dose adjustment is recommended with concomitant use of UBRELVY and moderate CYP3A4 inhibitors (e.g., cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, grapefruit juice) [see Dosage and Administration ( 2.2 )] . (उब्रोजेपेंट लेबल, दवाओं के इंटरैक्शन)

Concomitant administration of strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma estrogen and/or progestin concentrations. (एटोनोजेस्ट्रेल और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

CYP450 Inhibitors Grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine Increased exposure of amiodarone. (एमियोडेरोन लेबल, दवाओं के इंटरैक्शन)

ग्रेपफ्रूट का जूस ब्लड प्रेशर के लिए इस्तेमाल होने वाले कुछ कैल्शियम चैनल ब्लॉकर का खून में स्तर बढ़ा सकता है, जिससे ब्लड प्रेशर ज़रूरत से ज़्यादा गिर सकता है। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

ग्रेपफ्रूट का जूस ट्रांसप्लांट के बाद अंग की अस्वीकृति (रिजेक्शन) रोकने वाली दवाओं का खून में स्तर बढ़ाता है। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice are likely to increase avanafil exposure. (एवानाफिल लेबल, दवाओं के इंटरैक्शन)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in side effects. (एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

…Systemic Exposure of COCs (enzyme inhibitors): Concomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest. (एस्ट्राडियोल और डायनोजेस्ट लेबल, दवाओं के इंटरैक्शन)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and result in adverse reactions. (एस्ट्राडियोल और नॉरएथिस्टेरोन लेबल, दवाओं के इंटरैक्शन)

Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. (टैडालाफिल लेबल, दवाओं के इंटरैक्शन)

Therefore, give one third the recommended dosage of EMFLAZA when moderate or strong CYP3A4 inhibitors (e.g., clarithromycin, fluconazole, diltiazem, verapamil, grapefruit juice) are used concomitantly with EMFLAZA [see Dosage and Administration ( 2.5 ) and Clinical Pharmacology ( 12.3 )] . (डेफ्लाज़ाकॉर्ट लेबल, दवाओं के इंटरैक्शन)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (डेसोजेस्ट्रेल और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously co-administered with dofetilide as they can potentially increase dofetilide levels. (डोफेटिलाइड लेबल, दवाओं के इंटरैक्शन)

Monitor for increased dronabinol-related adverse reactions when dronabinol oral solution is co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice). (ड्रोनाबिनोल लेबल, दवाओं के इंटरैक्शन)

Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (e.g., ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the progestin or both. (ड्रोस्पिरेनोन और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

ग्रेपफ्रूट का जूस ब्लड प्रेशर के लिए इस्तेमाल होने वाले कुछ कैल्शियम चैनल ब्लॉकर का खून में स्तर बढ़ा सकता है, जिससे ब्लड प्रेशर ज़रूरत से ज़्यादा गिर सकता है। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

ग्रेपफ्रूट का जूस ब्लड प्रेशर के लिए इस्तेमाल होने वाले कुछ कैल्शियम चैनल ब्लॉकर का खून में स्तर बढ़ा सकता है, जिससे ब्लड प्रेशर ज़रूरत से ज़्यादा गिर सकता है। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Substances increasing the systemic concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the systemic concentrations of progestins, including norethindrone. (नॉरएथिस्टेरोन लेबल, दवाओं के इंटरैक्शन)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (नॉरएल्जेस्ट्रोमिन और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (नॉरजेस्टिमेट और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

Concomitant administration of CYP3A4 inhibitors such as itraconazole, fluconazole, grapefruit juice or ketoconazole may increase plasma hormone concentrations. (नॉरजेस्ट्रेल और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

Examples Clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, and voriconazole Intervention If a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor, dose adjustment of Paricalcitol Injection may be necessary. (पैरिकैल्सिटोल लेबल, दवाओं के इंटरैक्शन)

In addition, grapefruit juice was also reported to produce a 1.6-fold increase in the C max and a 1.9-fold increase in the AUC of praziquantel. (प्राज़िक्वांटेल लेबल, दवाओं के इंटरैक्शन)

Drugs that inhibit these CYP pathways (such as desipramine, paroxetine, ritonavir, sertraline for CYP2D6; ketoconazole, erythromycin, saquinavir, and grapefruit juice for CYP3A4; and amiodarone and tobacco smoke for CYP1A2) can be expected to cause increased plasma levels of propafenone. (प्रोपाफेनोन लेबल, चेतावनियां और सावधानियां)

ग्रेपफ्रूट का जूस इन दवाओं की उस मात्रा को बदल देता है जो खून तक पहुंचती है (ज़्यादातर की मात्रा बढ़ाता है, पर फेक्सोफेनाडीन की घटाता है)। (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Coadministration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism. (फेलोडिपिन लेबल, दवाओं के इंटरैक्शन)

No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem, verapamil and grapefruit juice). (फेसोटेरोडिन लेबल, दवाओं के इंटरैक्शन)

…telaprevir, telithromycin and conivaptan Examples of moderate CYP3A4 inhibitors Amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, and grapefruit juice Clinical Implications The concomitant use of ADDYI with moderate or strong CYP3A4 inhibitors increases flibanserin exposure compared to the use of ADDYI alone. (फ्लिबैनसेरिन लेबल, दवाओं के इंटरैक्शन)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice CYP3A4 Inducers Clinical Impact: The concomitant use of Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules and CYP3A4 inducers can result in lower codeine levels, greater norcodeine levels,… (ब्यूटाल्बिटल, पैरासिटामोल, कैफीन और कोडीन लेबल, दवाओं के इंटरैक्शन)

Moderate CYP3A Inhibitors Limit the dose of ASPRUZYO Sprinkle to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2), Clinical Pharmacology (12.3)]. (रैनोलाज़िन लेबल, दवाओं के इंटरैक्शन)

CYP3A inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice The effect of grapefruit juice on CYP3A4 enzymes (e.g., strong vs. moderate inhibition) depends on its brand, concentration, and preparation. , or ketoconazole may increase systemic exposure of the estrogen and/or progestin component of CHCs. (लेवोनॉरजेस्ट्रेल और एथिनिल एस्ट्राडियोल लेबल, दवाओं के इंटरैक्शन)

…recommended not to exceed a single 5 mg dose of vardenafil hydrochloride tablets in a 24-hour period when used in combination with erythromycin. [See Dosage and Administration (2.4) and Warnings and Precautions (5) .] Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice would likely increase vardenafil exposure. (वार्डेनाफिल लेबल, दवाओं के इंटरैक्शन)

Grapefruit juice may significantly increase verapamil levels ( 7.3 ) (वेरापामिल लेबल, दवाओं के इंटरैक्शन)

Inhibitors of CYP3A4 or CYP2C19 Inhibitors of CYP3A4 Coadministration of strong (e.g., ketoconazole) and moderate (e.g., erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to cilostazol. (सिलोस्टाज़ोल लेबल, दवाओं के इंटरैक्शन)

The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil). (सुवोरेक्सेंट लेबल, दवाओं के इंटरैक्शन)

Examples of less potent CYP 3A4 inhibitors include: saquinavir, nefazodone, fluconazole, fluoxetine, grapefruit juice, fluvoxamine, zileuton, metronidazole, and clotrimazole. (एर्गोटामिन और कैफीन लेबल, चेतावनियां)

…itraconazole, fluconazole, voriconazole ) , cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine, diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, quinine, quinupristin, ticlopidine, troleandomycin, valproate,… (कार्बामाज़ेपिन लेबल, दवाओं के इंटरैक्शन)

Quinine sulfate may be taken with grapefruit juice. (क्विनीन लेबल, दवाओं के इंटरैक्शन)

Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole. (डाइहाइड्रोएर्गोटामिन लेबल, चेतावनियां)

Strong and moderate CYP3A inhibitors include, but are not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil. (डेक्सट्रोमेथॉर्फन और क्विनिडिन लेबल, चेतावनियां और सावधानियां)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice. (फेंटानिल लेबल, दवाओं के इंटरैक्शन)

Examples of some of the strong CYP 3A4 inhibitors include saquinavir, grapefruit juice, nefazodone, macrolide antibiotics (e.g., troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). (मिथाइलएर्गोमेट्रिन लेबल, दवाओं के इंटरैक्शन)

Some botanicals and foods can interact with warfarin sodium through CYP450 interactions (e.g., echinacea, grapefruit juice, ginkgo, goldenseal, St. (वारफेरिन लेबल, दवाओं के इंटरैक्शन)

Examples: Anti-fungals: itraconazole, posaconazole, voriconazole Antibiotics: erythromycin and clarithromycin Antiretrovirals: ritonavir Grapefruit juice CYP3A4 Inducers Clinical Impact: Hydrocortisone is metabolized by cytochrome P450 3A4 (CYP3A4). (हाइड्रोकॉर्टिसोन लेबल, दवाओं के इंटरैक्शन)

The following have no clinically relevant effects on the pharmacokinetics of amlodipine: cimetidine, grapefruit juice, magnesium and aluminum hydroxide antacid, sildenafil. (टेल्मिसार्टन और एम्लोडिपिन लेबल, दवाओं के इंटरैक्शन)