Grejpfrut: interakcje

Grapefruit or grapefruit juice may also increase axitinib plasma concentrations and should be avoided. (etykieta leku Aksytynib, Interakcje z innymi lekami)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking amlodipine and atorvastatin tablets [see Drug Interactions (7.3) ]. (etykieta leku Amlodypina + atorwastatyna, Ostrzeżenia i środki ostrożności)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking LIPITOR [see Drug Interactions (7.1) ] . (etykieta leku Atorwastatyna, Ostrzeżenia i środki ostrożności)

Patients receiving buspirone should be advised to avoid drinking such large amounts of grapefruit juice. (etykieta leku Buspiron, Interakcje z innymi lekami)

Although the clinical significance of this interaction is unknown, grapefruit juice should be avoided. (etykieta leku Chinidyna, Interakcje z innymi lekami)

Grapefruit Juice Grapefruit and grapefruit juice affect metabolism, increasing blood concentrations of cyclosporine, thus should be avoided. (etykieta leku Cyklosporyna, Interakcje z innymi lekami)

• Grapefruit juice: Avoid concomitant use. (etykieta leku Dronedaron, Interakcje z innymi lekami)

Avoid food or drink containing grapefruit. (etykieta leku Eleksakaftor + tezakaftor + iwakaftor, Interakcje z innymi lekami)

Avoid co-administering erlotinib with strong CYP3A4 inhibitors (e.g., boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole, grapefruit or grapefruit juice) or a combined CYP3A4 and CYP1A2 inhibitor (e.g., ciprofloxacin). (etykieta leku Erlotynib, Interakcje z innymi lekami)

Intervention: Avoid grapefruit juice when taking VYTORIN. (etykieta leku Ezetymib + symwastatyna, Interakcje z innymi lekami)

Grapefruit juice may also increase plasma concentrations of imatinib; avoid grapefruit juice [see Clinical Pharmacology (12.3)] . (etykieta leku Imatynib, Interakcje z innymi lekami)

Avoid food or drink containing grapefruit. (etykieta leku Iwakaftor, Interakcje z innymi lekami)

Avoid ingestion of foods (e.g., grapefruit, grapefruit juice) or nutritional supplements that are known to inhibit cytochrome P450 while taking COMETRIQ. (etykieta leku Kabozantynib, Interakcje z innymi lekami)

CYP3A4 The concomitant use of colchicine capsules and CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil, etc.) should be avoided due to the potential for serious and life-threatening toxicity [see Warnings and Precautions (5.3) and Clinical Pharmacology (12) ] . (etykieta leku Kolchicyna, Interakcje z innymi lekami)

Avoid coadministration of VITRAKVI with strong CYP3A4 inhibitors, including grapefruit or grapefruit juice. (etykieta leku Larotrektynib, Interakcje z innymi lekami)

Patients must avoid grapefruit juice ( 4 , 5.6 , 7.1 ). (etykieta leku Lomitapid, Interakcje z innymi lekami)

…products Gemfibrozil Avoid with lovastatin Cyclosporine Danazol Do not exceed 20 mg lovastatin daily Diltiazem Dronedarone Verapamil Amiodarone Do not exceed 40 mg lovastatin daily Grapefruit juice Avoid grapefruit juice Immune-Mediated Necrotizing Myopathy There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated… (etykieta leku Lowastatyna, Ostrzeżenia)

•Avoid consumption of grapefruit or grapefruit juice during treatment with MOVANTIK [see Dosage and Administration (2.1) ] . (etykieta leku Naloksegol, Interakcje z innymi lekami)

Grapefruit juice should be avoided by patients on nifedipine. (etykieta leku Nifedypina, Środki ostrożności)

Avoid grapefruit juice. (etykieta leku Nimodypina, Interakcje z innymi lekami)

Avoid grapefruit or grapefruit juice during IBRANCE treatment. (etykieta leku Palbocyklib, Interakcje z innymi lekami)

Interaction with Food Patients should avoid grapefruit juice because it may inhibit the metabolism of pimozide by CYP 3A4. (etykieta leku Pimozyd, Interakcje z innymi lekami)

Avoid food or drink containing grapefruit. (etykieta leku Suzetrygina, Interakcje z innymi lekami)

Intervention: Avoid grapefruit juice when taking ZOCOR. (etykieta leku Symwastatyna, Interakcje z innymi lekami)

Grapefruit Juice Because grapefruit juice inhibits the CYP3A4-mediated metabolism of sirolimus, it must not be taken with sirolimus [ see Clinical Pharmacology (12.3) ]. (etykieta leku Syrolimus, Interakcje z innymi lekami)

Avoid grapefruit or grapefruit juice. (etykieta leku Takrolimus, Interakcje z innymi lekami)

Patients should avoid grapefruit juice beverages while taking SAMSCA [see Clinical Pharmacology (12.3) ] . (etykieta leku Tolwaptan, Interakcje z innymi lekami)

Grapefruit juice may also increase plasma concentrations of toremifene and should be avoided. (etykieta leku Toremifen, Interakcje z innymi lekami)

Food or drink containing grapefruit should be avoided during treatment with RINVOQ/RINVOQ LQ. (etykieta leku Upadacytynib, Interakcje z innymi lekami)

CYP450 Inhibitors Grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine Increased exposure of amiodarone. (etykieta leku Amiodaron, Interakcje z innymi lekami)

Sok grejpfrutowy może podnosić stężenie we krwi niektórych blokerów kanału wapniowego stosowanych w leczeniu nadciśnienia, co może powodować nadmierne obniżenie ciśnienia tętniczego. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice are likely to increase avanafil exposure. (etykieta leku Awanafil, Interakcje z innymi lekami)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice CYP3A4 Inducers Clinical Impact: The concomitant use of Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules and CYP3A4 inducers can result in lower codeine levels, greater norcodeine levels,… (etykieta leku Butalbital + paracetamol + kofeina + kodeina, Interakcje z innymi lekami)

Inhibitors of CYP3A4 or CYP2C19 Inhibitors of CYP3A4 Coadministration of strong (e.g., ketoconazole) and moderate (e.g., erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to cilostazol. (etykieta leku Cylostazol, Interakcje z innymi lekami)

Therefore, give one third the recommended dosage of EMFLAZA when moderate or strong CYP3A4 inhibitors (e.g., clarithromycin, fluconazole, diltiazem, verapamil, grapefruit juice) are used concomitantly with EMFLAZA [see Dosage and Administration ( 2.5 ) and Clinical Pharmacology ( 12.3 )] . (etykieta leku Deflazakort, Interakcje z innymi lekami)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (etykieta leku Dezogestrel + etynyloestradiol, Interakcje z innymi lekami)

Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously co-administered with dofetilide as they can potentially increase dofetilide levels. (etykieta leku Dofetylid, Interakcje z innymi lekami)

Monitor for increased dronabinol-related adverse reactions when dronabinol oral solution is co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice). (etykieta leku Dronabinol, Interakcje z innymi lekami)

Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (e.g., ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the progestin or both. (etykieta leku Drospirenon + etynyloestradiol, Interakcje z innymi lekami)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in side effects. (etykieta leku Estradiol, Interakcje z innymi lekami)

…Systemic Exposure of COCs (enzyme inhibitors): Concomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest. (etykieta leku Estradiol + dienogest, Interakcje z innymi lekami)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and result in adverse reactions. (etykieta leku Estradiol + noretysteron, Interakcje z innymi lekami)

Concomitant administration of strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma estrogen and/or progestin concentrations. (etykieta leku Etonogestrel + etynyloestradiol, Interakcje z innymi lekami)

Sok grejpfrutowy podnosi stężenie we krwi leków zapobiegających odrzuceniu przeszczepu. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Sok grejpfrutowy zmienia ilość tych leków, która dociera do krwiobiegu (w przypadku większości ją zwiększa, ale w przypadku feksofenadyny zmniejsza). (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Coadministration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism. (etykieta leku Felodypina, Interakcje z innymi lekami)

No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem, verapamil and grapefruit juice). (etykieta leku Fezoterodyna, Interakcje z innymi lekami)

…telaprevir, telithromycin and conivaptan Examples of moderate CYP3A4 inhibitors Amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, and grapefruit juice Clinical Implications The concomitant use of ADDYI with moderate or strong CYP3A4 inhibitors increases flibanserin exposure compared to the use of ADDYI alone. (etykieta leku Flibanseryna, Interakcje z innymi lekami)

Sok grejpfrutowy może podnosić stężenie we krwi niektórych blokerów kanału wapniowego stosowanych w leczeniu nadciśnienia, co może powodować nadmierne obniżenie ciśnienia tętniczego. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Examples of moderate CYP3A4 inhibitors include diltiazem, verapamil, and grapefruit juice [ s ee Warnings and Precautions ( 5.3 ) and Clinical Pharmacology ( 12.3 )] . (etykieta leku Iwabradyna, Interakcje z innymi lekami)

CYP3A inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice The effect of grapefruit juice on CYP3A4 enzymes (e.g., strong vs. moderate inhibition) depends on its brand, concentration, and preparation. , or ketoconazole may increase systemic exposure of the estrogen and/or progestin component of CHCs. (etykieta leku Lewonorgestrel + etynyloestradiol, Interakcje z innymi lekami)

Sok grejpfrutowy może podnosić stężenie we krwi niektórych blokerów kanału wapniowego stosowanych w leczeniu nadciśnienia, co może powodować nadmierne obniżenie ciśnienia tętniczego. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Sok grejpfrutowy może podnosić stężenie we krwi niektórych blokerów kanału wapniowego stosowanych w leczeniu nadciśnienia, co może powodować nadmierne obniżenie ciśnienia tętniczego. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (etykieta leku Norelgestromin + etynyloestradiol, Interakcje z innymi lekami)

Substances increasing the systemic concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the systemic concentrations of progestins, including norethindrone. (etykieta leku Noretysteron, Interakcje z innymi lekami)

Concomitant administration of CYP3A4 inhibitors such as itraconazole, fluconazole, grapefruit juice or ketoconazole may increase plasma hormone concentrations. (etykieta leku Norgestrel + etynyloestradiol, Interakcje z innymi lekami)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (etykieta leku Norgestymat + etynyloestradiol, Interakcje z innymi lekami)

Examples Clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, and voriconazole Intervention If a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor, dose adjustment of Paricalcitol Injection may be necessary. (etykieta leku Parykalcytol, Interakcje z innymi lekami)

In addition, grapefruit juice was also reported to produce a 1.6-fold increase in the C max and a 1.9-fold increase in the AUC of praziquantel. (etykieta leku Prazykwantel, Interakcje z innymi lekami)

Drugs that inhibit these CYP pathways (such as desipramine, paroxetine, ritonavir, sertraline for CYP2D6; ketoconazole, erythromycin, saquinavir, and grapefruit juice for CYP3A4; and amiodarone and tobacco smoke for CYP1A2) can be expected to cause increased plasma levels of propafenone. (etykieta leku Propafenon, Ostrzeżenia i środki ostrożności)

Moderate CYP3A Inhibitors Limit the dose of ASPRUZYO Sprinkle to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2), Clinical Pharmacology (12.3)]. (etykieta leku Ranolazyna, Interakcje z innymi lekami)

The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil). (etykieta leku Suworeksant, Interakcje z innymi lekami)

Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. (etykieta leku Tadalafil, Interakcje z innymi lekami)

Dose adjustment is recommended with concomitant use of UBRELVY and moderate CYP3A4 inhibitors (e.g., cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, grapefruit juice) [see Dosage and Administration ( 2.2 )] . (etykieta leku Ubrogepant, Interakcje z innymi lekami)

…recommended not to exceed a single 5 mg dose of vardenafil hydrochloride tablets in a 24-hour period when used in combination with erythromycin. [See Dosage and Administration (2.4) and Warnings and Precautions (5) .] Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice would likely increase vardenafil exposure. (etykieta leku Wardenafil, Interakcje z innymi lekami)

Grapefruit juice may significantly increase verapamil levels ( 7.3 ) (etykieta leku Werapamil, Interakcje z innymi lekami)

Quinine sulfate may be taken with grapefruit juice. (etykieta leku Chinina, Interakcje z innymi lekami)

Strong and moderate CYP3A inhibitors include, but are not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil. (etykieta leku Dekstrometorfan + chinidyna, Ostrzeżenia i środki ostrożności)

Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole. (etykieta leku Dihydroergotamina, Ostrzeżenia)

Examples of less potent CYP 3A4 inhibitors include: saquinavir, nefazodone, fluconazole, fluoxetine, grapefruit juice, fluvoxamine, zileuton, metronidazole, and clotrimazole. (etykieta leku Ergotamina + kofeina, Ostrzeżenia)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice. (etykieta leku Fentanyl, Interakcje z innymi lekami)

Examples: Anti-fungals: itraconazole, posaconazole, voriconazole Antibiotics: erythromycin and clarithromycin Antiretrovirals: ritonavir Grapefruit juice CYP3A4 Inducers Clinical Impact: Hydrocortisone is metabolized by cytochrome P450 3A4 (CYP3A4). (etykieta leku Hydrokortyzon, Interakcje z innymi lekami)

…itraconazole, fluconazole, voriconazole ) , cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine, diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, quinine, quinupristin, ticlopidine, troleandomycin, valproate,… (etykieta leku Karbamazepina, Interakcje z innymi lekami)

Examples of some of the strong CYP 3A4 inhibitors include saquinavir, grapefruit juice, nefazodone, macrolide antibiotics (e.g., troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). (etykieta leku Metyloergometryna, Interakcje z innymi lekami)

Some botanicals and foods can interact with warfarin sodium through CYP450 interactions (e.g., echinacea, grapefruit juice, ginkgo, goldenseal, St. (etykieta leku Warfaryna, Interakcje z innymi lekami)

The following have no clinically relevant effects on the pharmacokinetics of amlodipine: cimetidine, grapefruit juice, magnesium and aluminum hydroxide antacid, sildenafil. (etykieta leku Telmisartan + amlodypina, Interakcje z innymi lekami)