Greyfurt etkileşimleri

Grapefruit or grapefruit juice may also increase axitinib plasma concentrations and should be avoided. (Aksitinib etiketi, İlaç etkileşimleri)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking amlodipine and atorvastatin tablets [see Drug Interactions (7.3) ]. (Amlodipin ve atorvastatin etiketi, Uyarılar ve önlemler)

Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking LIPITOR [see Drug Interactions (7.1) ] . (Atorvastatin etiketi, Uyarılar ve önlemler)

Patients receiving buspirone should be advised to avoid drinking such large amounts of grapefruit juice. (Buspiron etiketi, İlaç etkileşimleri)

• Grapefruit juice: Avoid concomitant use. (Dronedaron etiketi, İlaç etkileşimleri)

Avoid food or drink containing grapefruit. (Eleksakaftor, tezakaftor ve ivakaftor etiketi, İlaç etkileşimleri)

Avoid co-administering erlotinib with strong CYP3A4 inhibitors (e.g., boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole, grapefruit or grapefruit juice) or a combined CYP3A4 and CYP1A2 inhibitor (e.g., ciprofloxacin). (Erlotinib etiketi, İlaç etkileşimleri)

Intervention: Avoid grapefruit juice when taking VYTORIN. (Ezetimib ve simvastatin etiketi, İlaç etkileşimleri)

Grapefruit juice may also increase plasma concentrations of imatinib; avoid grapefruit juice [see Clinical Pharmacology (12.3)] . (İmatinib etiketi, İlaç etkileşimleri)

Avoid food or drink containing grapefruit. (İvakaftor etiketi, İlaç etkileşimleri)

Avoid ingestion of foods (e.g., grapefruit, grapefruit juice) or nutritional supplements that are known to inhibit cytochrome P450 while taking COMETRIQ. (Kabozantinib etiketi, İlaç etkileşimleri)

Although the clinical significance of this interaction is unknown, grapefruit juice should be avoided. (Kinidin etiketi, İlaç etkileşimleri)

CYP3A4 The concomitant use of colchicine capsules and CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil, etc.) should be avoided due to the potential for serious and life-threatening toxicity [see Warnings and Precautions (5.3) and Clinical Pharmacology (12) ] . (Kolşisin etiketi, İlaç etkileşimleri)

Avoid coadministration of VITRAKVI with strong CYP3A4 inhibitors, including grapefruit or grapefruit juice. (Larotrektinib etiketi, İlaç etkileşimleri)

Patients must avoid grapefruit juice ( 4 , 5.6 , 7.1 ). (Lomitapid etiketi, İlaç etkileşimleri)

…products Gemfibrozil Avoid with lovastatin Cyclosporine Danazol Do not exceed 20 mg lovastatin daily Diltiazem Dronedarone Verapamil Amiodarone Do not exceed 40 mg lovastatin daily Grapefruit juice Avoid grapefruit juice Immune-Mediated Necrotizing Myopathy There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated… (Lovastatin etiketi, Uyarılar)

•Avoid consumption of grapefruit or grapefruit juice during treatment with MOVANTIK [see Dosage and Administration (2.1) ] . (Naloksegol etiketi, İlaç etkileşimleri)

Grapefruit juice should be avoided by patients on nifedipine. (Nifedipin etiketi, Önlemler)

Avoid grapefruit juice. (Nimodipin etiketi, İlaç etkileşimleri)

Avoid grapefruit or grapefruit juice during IBRANCE treatment. (Palbosiklib etiketi, İlaç etkileşimleri)

Interaction with Food Patients should avoid grapefruit juice because it may inhibit the metabolism of pimozide by CYP 3A4. (Pimozid etiketi, İlaç etkileşimleri)

Grapefruit Juice Grapefruit and grapefruit juice affect metabolism, increasing blood concentrations of cyclosporine, thus should be avoided. (Siklosporin etiketi, İlaç etkileşimleri)

Intervention: Avoid grapefruit juice when taking ZOCOR. (Simvastatin etiketi, İlaç etkileşimleri)

Grapefruit Juice Because grapefruit juice inhibits the CYP3A4-mediated metabolism of sirolimus, it must not be taken with sirolimus [ see Clinical Pharmacology (12.3) ]. (Sirolimus etiketi, İlaç etkileşimleri)

Avoid food or drink containing grapefruit. (Suzetrijin etiketi, İlaç etkileşimleri)

Avoid grapefruit or grapefruit juice. (Takrolimus etiketi, İlaç etkileşimleri)

Patients should avoid grapefruit juice beverages while taking SAMSCA [see Clinical Pharmacology (12.3) ] . (Tolvaptan etiketi, İlaç etkileşimleri)

Grapefruit juice may also increase plasma concentrations of toremifene and should be avoided. (Toremifen etiketi, İlaç etkileşimleri)

Food or drink containing grapefruit should be avoided during treatment with RINVOQ/RINVOQ LQ. (Upadasitinib etiketi, İlaç etkileşimleri)

CYP450 Inhibitors Grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine Increased exposure of amiodarone. (Amiodaron etiketi, İlaç etkileşimleri)

Greyfurt suyu, tansiyon için kullanılan bazı kalsiyum kanal blokerlerinin kan düzeylerini yükseltebilir; bu da kan basıncının aşırı düşmesine neden olabilir. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice are likely to increase avanafil exposure. (Avanafil etiketi, İlaç etkileşimleri)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice CYP3A4 Inducers Clinical Impact: The concomitant use of Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules and CYP3A4 inducers can result in lower codeine levels, greater norcodeine levels,… (Butalbital, parasetamol, kafein ve kodein etiketi, İlaç etkileşimleri)

Therefore, give one third the recommended dosage of EMFLAZA when moderate or strong CYP3A4 inhibitors (e.g., clarithromycin, fluconazole, diltiazem, verapamil, grapefruit juice) are used concomitantly with EMFLAZA [see Dosage and Administration ( 2.5 ) and Clinical Pharmacology ( 12.3 )] . (Deflazakort etiketi, İlaç etkileşimleri)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (Desogestrel ve etinilestradiol etiketi, İlaç etkileşimleri)

Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, zafirlukast) should be cautiously co-administered with dofetilide as they can potentially increase dofetilide levels. (Dofetilid etiketi, İlaç etkileşimleri)

Monitor for increased dronabinol-related adverse reactions when dronabinol oral solution is co-administered with inhibitors of CYP2C9 (e.g., amiodarone, fluconazole) and inhibitors of CYP3A4 enzymes (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, erythromycin, grapefruit juice). (Dronabinol etiketi, İlaç etkileşimleri)

Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (e.g., ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the progestin or both. (Drospirenon ve etinilestradiol etiketi, İlaç etkileşimleri)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in side effects. (Estradiol etiketi, İlaç etkileşimleri)

…Systemic Exposure of COCs (enzyme inhibitors): Concomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest. (Estradiol ve dienogest etiketi, İlaç etkileşimleri)

Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and result in adverse reactions. (Estradiol ve noretisteron etiketi, İlaç etkileşimleri)

Concomitant administration of strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma estrogen and/or progestin concentrations. (Etonogestrel ve etinilestradiol etiketi, İlaç etkileşimleri)

Greyfurt suyu, nakil sonrası organ reddini önleyen ilaçların kan düzeylerini yükseltir. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Greyfurt suyu, bu ilaçların kan dolaşımına ulaşan miktarını değiştirir (çoğununkini artırır, feksofenadininkini ise azaltır). (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Coadministration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism. (Felodipin etiketi, İlaç etkileşimleri)

No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem, verapamil and grapefruit juice). (Fesoterodin etiketi, İlaç etkileşimleri)

…telaprevir, telithromycin and conivaptan Examples of moderate CYP3A4 inhibitors Amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, and grapefruit juice Clinical Implications The concomitant use of ADDYI with moderate or strong CYP3A4 inhibitors increases flibanserin exposure compared to the use of ADDYI alone. (Flibanserin etiketi, İlaç etkileşimleri)

Greyfurt suyu, tansiyon için kullanılan bazı kalsiyum kanal blokerlerinin kan düzeylerini yükseltebilir; bu da kan basıncının aşırı düşmesine neden olabilir. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Examples of moderate CYP3A4 inhibitors include diltiazem, verapamil, and grapefruit juice [ s ee Warnings and Precautions ( 5.3 ) and Clinical Pharmacology ( 12.3 )] . (İvabradin etiketi, İlaç etkileşimleri)

CYP3A inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice The effect of grapefruit juice on CYP3A4 enzymes (e.g., strong vs. moderate inhibition) depends on its brand, concentration, and preparation. , or ketoconazole may increase systemic exposure of the estrogen and/or progestin component of CHCs. (Levonorgestrel ve etinilestradiol etiketi, İlaç etkileşimleri)

Greyfurt suyu, tansiyon için kullanılan bazı kalsiyum kanal blokerlerinin kan düzeylerini yükseltebilir; bu da kan basıncının aşırı düşmesine neden olabilir. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

Greyfurt suyu, tansiyon için kullanılan bazı kalsiyum kanal blokerlerinin kan düzeylerini yükseltebilir; bu da kan basıncının aşırı düşmesine neden olabilir. (FDA, Grapefruit Juice and Some Drugs Don't Mix)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (Norelgestromin ve etinilestradiol etiketi, İlaç etkileşimleri)

Substances increasing the systemic concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the systemic concentrations of progestins, including norethindrone. (Noretisteron etiketi, İlaç etkileşimleri)

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations. (Norgestimat ve etinilestradiol etiketi, İlaç etkileşimleri)

Concomitant administration of CYP3A4 inhibitors such as itraconazole, fluconazole, grapefruit juice or ketoconazole may increase plasma hormone concentrations. (Norgestrel ve etinilestradiol etiketi, İlaç etkileşimleri)

Examples Clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, and voriconazole Intervention If a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor, dose adjustment of Paricalcitol Injection may be necessary. (Parikalsitol etiketi, İlaç etkileşimleri)

In addition, grapefruit juice was also reported to produce a 1.6-fold increase in the C max and a 1.9-fold increase in the AUC of praziquantel. (Prazikuantel etiketi, İlaç etkileşimleri)

Drugs that inhibit these CYP pathways (such as desipramine, paroxetine, ritonavir, sertraline for CYP2D6; ketoconazole, erythromycin, saquinavir, and grapefruit juice for CYP3A4; and amiodarone and tobacco smoke for CYP1A2) can be expected to cause increased plasma levels of propafenone. (Propafenon etiketi, Uyarılar ve önlemler)

Moderate CYP3A Inhibitors Limit the dose of ASPRUZYO Sprinkle to 500 mg twice daily in patients on moderate CYP3A inhibitors, including diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice or grapefruit-containing products [see Dosage and Administration (2.2), Clinical Pharmacology (12.3)]. (Ranolazin etiketi, İlaç etkileşimleri)

Inhibitors of CYP3A4 or CYP2C19 Inhibitors of CYP3A4 Coadministration of strong (e.g., ketoconazole) and moderate (e.g., erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to cilostazol. (Silostazol etiketi, İlaç etkileşimleri)

The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil). (Suvoreksant etiketi, İlaç etkileşimleri)

Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. (Tadalafil etiketi, İlaç etkileşimleri)

Dose adjustment is recommended with concomitant use of UBRELVY and moderate CYP3A4 inhibitors (e.g., cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, grapefruit juice) [see Dosage and Administration ( 2.2 )] . (Ubrogepant etiketi, İlaç etkileşimleri)

…recommended not to exceed a single 5 mg dose of vardenafil hydrochloride tablets in a 24-hour period when used in combination with erythromycin. [See Dosage and Administration (2.4) and Warnings and Precautions (5) .] Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice would likely increase vardenafil exposure. (Vardenafil etiketi, İlaç etkileşimleri)

Grapefruit juice may significantly increase verapamil levels ( 7.3 ) (Verapamil etiketi, İlaç etkileşimleri)

Strong and moderate CYP3A inhibitors include, but are not limited to, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil. (Dekstrometorfan ve kinidin etiketi, Uyarılar ve önlemler)

Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole. (Dihidroergotamin etiketi, Uyarılar)

Examples of less potent CYP 3A4 inhibitors include: saquinavir, nefazodone, fluconazole, fluoxetine, grapefruit juice, fluvoxamine, zileuton, metronidazole, and clotrimazole. (Ergotamin ve kafein etiketi, Uyarılar)

Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), protease inhibitors (e.g., ritonavir), grapefruit juice. (Fentanil etiketi, İlaç etkileşimleri)

Examples: Anti-fungals: itraconazole, posaconazole, voriconazole Antibiotics: erythromycin and clarithromycin Antiretrovirals: ritonavir Grapefruit juice CYP3A4 Inducers Clinical Impact: Hydrocortisone is metabolized by cytochrome P450 3A4 (CYP3A4). (Hidrokortizon etiketi, İlaç etkileşimleri)

…itraconazole, fluconazole, voriconazole ) , cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine, diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, quinine, quinupristin, ticlopidine, troleandomycin, valproate,… (Karbamazepin etiketi, İlaç etkileşimleri)

Quinine sulfate may be taken with grapefruit juice. (Kinin etiketi, İlaç etkileşimleri)

Examples of some of the strong CYP 3A4 inhibitors include saquinavir, grapefruit juice, nefazodone, macrolide antibiotics (e.g., troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). (Metilergometrin etiketi, İlaç etkileşimleri)

Some botanicals and foods can interact with warfarin sodium through CYP450 interactions (e.g., echinacea, grapefruit juice, ginkgo, goldenseal, St. (Varfarin etiketi, İlaç etkileşimleri)

The following have no clinically relevant effects on the pharmacokinetics of amlodipine: cimetidine, grapefruit juice, magnesium and aluminum hydroxide antacid, sildenafil. (Telmisartan ve amlodipin etiketi, İlaç etkileşimleri)