Interaction Checker

Atovaquone and proguanil interactions

Atovaquone and proguanil (Malarone), an antimalarial has 17 documented interactions across the FDA labels and fact sheets we index: 1 major, 16 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (1)

  • RifampinantibioticMajor

    • Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (Atovaquone and proguanil label, Drug interactions)

Moderate interactions (16)

  • ApixabananticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • ChloroquineantimalarialModerate

    Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (Chloroquine label, Warnings)

  • DabigatrananticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • Doxycyclinetetracycline antibioticModerate

    • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • EdoxabananticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • HeparinanticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • HydroxychloroquineQT-prolonging drugModerate

    Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (Hydroxychloroquine label, Drug interactions)

  • Lidocaine and prilocainelocal anestheticModerate

    …prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (Lidocaine and prilocaine label, Drug interactions)

  • Metoclopramidedopamine antagonistModerate

    Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (Atovaquone and proguanil label, Drug interactions)

  • Minocyclinetetracycline antibioticModerate

    • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • RitonavirantiretroviralModerate

    Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (Ritonavir label, Drug interactions)

  • RivaroxabananticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

  • Tetracyclinetetracycline antibioticModerate

    • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • WarfarinanticoagulantModerate

    • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Atovaquone and proguanil label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.