Interações de Atovaquona + proguanil

Atovaquone/ proguanil ↓ atovaquone ↓ proguanil Concomitant administration is not recommended. (bula de Efavirenz + lamivudina + tenofovir, Interações medicamentosas)

Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (bula de Penicilamina, Precauções)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase… (bula de Articaína + epinefrina, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (bula de Bupivacaína, Interações medicamentosas)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (bula de Bupivacaína + epinefrina, Interações medicamentosas)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (bula de Cloroprocaína, Precauções)

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (bula de Cloroquina, Advertências)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

Antimalarial : artemether/lumefantrine ↓ artemether ↓ dihydroartemisinin ↑ lumefantrine ↔ darunavir The combination of PREZISTA/ritonavir and artemether/lumefantrine can be used without dose adjustments. (bula de Darunavir, Interações medicamentosas)

Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation. (bula de Darunavir + cobicistate, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. (bula de Droperidol, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation. (bula de Efavirenz, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

Antimalarial : artemether/lumefantrine ↔ etravirine ↓ artemether ↓ dihydroartemisinin ↓ lumefantrine Caution is warranted when co-administering Etravirine and artemether/lumefantrine as it is unknown whether the decrease in exposure of artemether or its active metabolite, dihydroartemisinin, could result in decreased antimalarial efficacy. (bula de Etravirina, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (bula de Hidroxicloroquina, Interações medicamentosas)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (bula de Lidocaína + epinefrina, Interações medicamentosas)

…prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (bula de Lidocaína + prilocaína, Interações medicamentosas)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone doses may be needed. (bula de Lopinavir + ritonavir, Interações medicamentosas)

Other Antimalarial Drugs Concomitant administration of mefloquine and other related antimalarial compounds (e.g., quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions (see WARNINGS ). (bula de Mefloquina, Interações medicamentosas)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (bula de Mepivacaína, Interações medicamentosas)

Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (bula de Atovaquona + proguanil, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim- sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrexate), while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. (bula de Pirimetamina, Interações medicamentosas)

…ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (bula de Prilocaína + epinefrina, Interações medicamentosas)

…quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol… (bula de Rifapentina, Interações medicamentosas)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (bula de Ritonavir, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN should be… (bula de Ropivacaína, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (bula de Atovaquona + proguanil, Interações medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (bula de Atovaquona + proguanil, Interações medicamentosas)

Pediatric use In antimalarial trials, quinidine was as safe and effective in pediatric patients as in adults. (bula de Quinidina, Precauções)

Other antimalarials (e.g., halofantrine, mefloquine). (bula de Quinina, Interações medicamentosas)