Interacciones de Atovacuona y proguanil

Atovaquone/ proguanil ↓ atovaquone ↓ proguanil Concomitant administration is not recommended. (etiqueta de Efavirenz, lamivudina y tenofovir, Interacciones medicamentosas)

Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (etiqueta de Penicilamina, Precauciones)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase… (etiqueta de Articaína y adrenalina, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etiqueta de Bupivacaína, Interacciones medicamentosas)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etiqueta de Bupivacaína y adrenalina, Interacciones medicamentosas)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etiqueta de Cloroprocaína, Precauciones)

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (etiqueta de Cloroquina, Advertencias)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Antimalarial : artemether/lumefantrine ↓ artemether ↓ dihydroartemisinin ↑ lumefantrine ↔ darunavir The combination of PREZISTA/ritonavir and artemether/lumefantrine can be used without dose adjustments. (etiqueta de Darunavir, Interacciones medicamentosas)

Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation. (etiqueta de Darunavir y cobicistat, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. (etiqueta de Droperidol, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation. (etiqueta de Efavirenz, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Antimalarial : artemether/lumefantrine ↔ etravirine ↓ artemether ↓ dihydroartemisinin ↓ lumefantrine Caution is warranted when co-administering Etravirine and artemether/lumefantrine as it is unknown whether the decrease in exposure of artemether or its active metabolite, dihydroartemisinin, could result in decreased antimalarial efficacy. (etiqueta de Etravirina, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (etiqueta de Hidroxicloroquina, Interacciones medicamentosas)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etiqueta de Lidocaína y adrenalina, Interacciones medicamentosas)

…prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etiqueta de Lidocaína y prilocaína, Interacciones medicamentosas)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone doses may be needed. (etiqueta de Lopinavir y ritonavir, Interacciones medicamentosas)

Other Antimalarial Drugs Concomitant administration of mefloquine and other related antimalarial compounds (e.g., quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions (see WARNINGS ). (etiqueta de Mefloquina, Interacciones medicamentosas)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etiqueta de Mepivacaína, Interacciones medicamentosas)

Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim- sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrexate), while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. (etiqueta de Pirimetamina, Interacciones medicamentosas)

…ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (etiqueta de Prilocaína y adrenalina, Interacciones medicamentosas)

…quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol… (etiqueta de Rifapentina, Interacciones medicamentosas)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (etiqueta de Ritonavir, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN should be… (etiqueta de Ropivacaína, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etiqueta de Atovacuona y proguanil, Interacciones medicamentosas)

Pediatric use In antimalarial trials, quinidine was as safe and effective in pediatric patients as in adults. (etiqueta de Quinidina, Precauciones)

Other antimalarials (e.g., halofantrine, mefloquine). (etiqueta de Quinina, Interacciones medicamentosas)