Atowakwon + proguanil: interakcje

Atovaquone/ proguanil ↓ atovaquone ↓ proguanil Concomitant administration is not recommended. (etykieta leku Efawirenz + lamiwudyna + tenofowir, Interakcje z innymi lekami)

Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (etykieta leku Penicylamina, Środki ostrożności)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase… (etykieta leku Artykaina + adrenalina, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etykieta leku Bupiwakaina, Interakcje z innymi lekami)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etykieta leku Bupiwakaina + adrenalina, Interakcje z innymi lekami)

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (etykieta leku Chlorochina, Ostrzeżenia)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etykieta leku Chloroprokaina, Środki ostrożności)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Antimalarial : artemether/lumefantrine ↓ artemether ↓ dihydroartemisinin ↑ lumefantrine ↔ darunavir The combination of PREZISTA/ritonavir and artemether/lumefantrine can be used without dose adjustments. (etykieta leku Darunawir, Interakcje z innymi lekami)

Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation. (etykieta leku Darunawir + kobicystat, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. (etykieta leku Droperydol, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation. (etykieta leku Efawirenz, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Antimalarial : artemether/lumefantrine ↔ etravirine ↓ artemether ↓ dihydroartemisinin ↓ lumefantrine Caution is warranted when co-administering Etravirine and artemether/lumefantrine as it is unknown whether the decrease in exposure of artemether or its active metabolite, dihydroartemisinin, could result in decreased antimalarial efficacy. (etykieta leku Etrawiryna, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (etykieta leku Hydroksychlorochina, Interakcje z innymi lekami)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (etykieta leku Lidokaina + adrenalina, Interakcje z innymi lekami)

…prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etykieta leku Lidokaina + prylokaina, Interakcje z innymi lekami)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone doses may be needed. (etykieta leku Lopinawir + rytonawir, Interakcje z innymi lekami)

Other Antimalarial Drugs Concomitant administration of mefloquine and other related antimalarial compounds (e.g., quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions (see WARNINGS ). (etykieta leku Meflochina, Interakcje z innymi lekami)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (etykieta leku Mepiwakaina, Interakcje z innymi lekami)

Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim- sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrexate), while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. (etykieta leku Pirymetamina, Interakcje z innymi lekami)

…ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (etykieta leku Prylokaina + adrenalina, Interakcje z innymi lekami)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN should be… (etykieta leku Ropiwakaina, Interakcje z innymi lekami)

…quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol… (etykieta leku Ryfapentyna, Interakcje z innymi lekami)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (etykieta leku Rytonawir, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (etykieta leku Atowakwon + proguanil, Interakcje z innymi lekami)

Pediatric use In antimalarial trials, quinidine was as safe and effective in pediatric patients as in adults. (etykieta leku Chinidyna, Środki ostrożności)

Other antimalarials (e.g., halofantrine, mefloquine). (etykieta leku Chinina, Interakcje z innymi lekami)