Interaksi Atovakuon dan proguanil

Atovaquone/ proguanil ↓ atovaquone ↓ proguanil Concomitant administration is not recommended. (label Efavirenz, lamivudin, dan tenofovir, Interaksi obat)

Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (label Penisilamin, Perhatian)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (label Atovakuon dan proguanil, Interaksi obat)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (label Atovakuon dan proguanil, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase… (label Artikain dan epinefrin, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (label Bupivakain, Interaksi obat)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (label Bupivakain dan epinefrin, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

Antimalarial : artemether/lumefantrine ↓ artemether ↓ dihydroartemisinin ↑ lumefantrine ↔ darunavir The combination of PREZISTA/ritonavir and artemether/lumefantrine can be used without dose adjustments. (label Darunavir, Interaksi obat)

Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation. (label Darunavir dan kobisistat, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. (label Droperidol, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation. (label Efavirenz, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

Antimalarial : artemether/lumefantrine ↔ etravirine ↓ artemether ↓ dihydroartemisinin ↓ lumefantrine Caution is warranted when co-administering Etravirine and artemether/lumefantrine as it is unknown whether the decrease in exposure of artemether or its active metabolite, dihydroartemisinin, could result in decreased antimalarial efficacy. (label Etravirin, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (label Hidroksiklorokuin, Interaksi obat)

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (label Klorokuin, Peringatan)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (label Kloroprokain, Perhatian)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (label Lidokain dan epinefrin, Interaksi obat)

…prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (label Lidokain dan prilokain, Interaksi obat)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone doses may be needed. (label Lopinavir dan ritonavir, Interaksi obat)

Other Antimalarial Drugs Concomitant administration of mefloquine and other related antimalarial compounds (e.g., quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions (see WARNINGS ). (label Meflokuin, Interaksi obat)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (label Mepivakain, Interaksi obat)

Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (label Atovakuon dan proguanil, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim- sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrexate), while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. (label Pirimetamin, Interaksi obat)

…ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (label Prilokain dan epinefrin, Interaksi obat)

…quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol… (label Rifapentin, Interaksi obat)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (label Ritonavir, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN should be… (label Ropivakain, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (label Atovakuon dan proguanil, Interaksi obat)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (label Atovakuon dan proguanil, Interaksi obat)

Pediatric use In antimalarial trials, quinidine was as safe and effective in pediatric patients as in adults. (label Kuinidin, Perhatian)

Other antimalarials (e.g., halofantrine, mefloquine). (label Kuinin, Interaksi obat)