Wechselwirkungen von Atovaquon und Proguanil

Atovaquone/ proguanil ↓ atovaquone ↓ proguanil Concomitant administration is not recommended. (Fachinformation zu Efavirenz, Lamivudin und Tenofovir, Arzneimittelwechselwirkungen)

Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Fachinformation zu Penicillamin, Vorsichtsmaßnahmen)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase… (Fachinformation zu Articain und Adrenalin, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Bupivacain, Arzneimittelwechselwirkungen)

• Drugs Associated with Methemoglobinemia : Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Bupivacain und Adrenalin, Arzneimittelwechselwirkungen)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (Fachinformation zu Chloroprocain, Vorsichtsmaßnahmen)

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy. (Fachinformation zu Chloroquin, Warnhinweise)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Antimalarial : artemether/lumefantrine ↓ artemether ↓ dihydroartemisinin ↑ lumefantrine ↔ darunavir The combination of PREZISTA/ritonavir and artemether/lumefantrine can be used without dose adjustments. (Fachinformation zu Darunavir, Arzneimittelwechselwirkungen)

Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation. (Fachinformation zu Darunavir und Cobicistat, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. (Fachinformation zu Droperidol, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation. (Fachinformation zu Efavirenz, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Antimalarial : artemether/lumefantrine ↔ etravirine ↓ artemether ↓ dihydroartemisinin ↓ lumefantrine Caution is warranted when co-administering Etravirine and artemether/lumefantrine as it is unknown whether the decrease in exposure of artemether or its active metabolite, dihydroartemisinin, could result in decreased antimalarial efficacy. (Fachinformation zu Etravirin, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Co-administration of PLAQUENIL with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures. (Fachinformation zu Hydroxychloroquin, Arzneimittelwechselwirkungen)

Drugs Associated with Methemoglobinemia: Patients are at increased risk of developing methemoglobinemia when concurrently exposed to nitrates, nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, and other drugs. (Fachinformation zu Lidocain und Adrenalin, Arzneimittelwechselwirkungen)

…prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (Fachinformation zu Lidocain und Prilocain, Arzneimittelwechselwirkungen)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone doses may be needed. (Fachinformation zu Lopinavir und Ritonavir, Arzneimittelwechselwirkungen)

Other Antimalarial Drugs Concomitant administration of mefloquine and other related antimalarial compounds (e.g., quinine, quinidine and chloroquine) may produce electrocardiographic abnormalities and increase the risk of convulsions (see WARNINGS ). (Fachinformation zu Mefloquin, Arzneimittelwechselwirkungen)

…procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (Fachinformation zu Mepivacain, Arzneimittelwechselwirkungen)

Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] . (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

…ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (Fachinformation zu Prilocain und Adrenalin, Arzneimittelwechselwirkungen)

However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim- sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrexate), while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. (Fachinformation zu Pyrimethamin, Arzneimittelwechselwirkungen)

…quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital Benzodiazepines Diazepam Beta-Blockers Propranolol… (Fachinformation zu Rifapentin, Arzneimittelwechselwirkungen)

Antiparasitic: atovaquone ↓ atovaquone Clinical significance is unknown; however, increase in atovaquone dose may be needed. (Fachinformation zu Ritonavir, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

…ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN should be… (Fachinformation zu Ropivacain, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (Fachinformation zu Atovaquon und Proguanil, Arzneimittelwechselwirkungen)

Pediatric use In antimalarial trials, quinidine was as safe and effective in pediatric patients as in adults. (Fachinformation zu Chinidin, Vorsichtsmaßnahmen)

Other antimalarials (e.g., halofantrine, mefloquine). (Fachinformation zu Chinin, Arzneimittelwechselwirkungen)