Bikalutamid: interakcje

These drugs include, but are not limited to, the following: the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin the androgen receptor inhibitor enzalutamide the antimycobacterials rifampin, rifapentine the cytotoxic agent mitotane St. (etykieta leku Dorawiryna, Przeciwwskazania)

Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant female who receives finasteride. (etykieta leku Finasteryd, Przeciwwskazania)

CONTRAINDICATIONS: Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (etykieta leku Gonadotropina kosmówkowa, Przeciwwskazania)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

PRECAUTIONS General Induction of androgen secretion by hCG may cause fluid retention. (etykieta leku Choriogonadotropina alfa, Środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (etykieta leku Estradiol + noretysteron, Ostrzeżenia i środki ostrożności)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (etykieta leku Estrogeny skoniugowane, Środki ostrożności)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (etykieta leku Estrogeny skoniugowane + bazedoksyfen, Ostrzeżenia i środki ostrożności)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (etykieta leku Fludrokortyzon, Interakcje z innymi lekami)

For Men : Clinical monitoring for spermatogenesis utilizes the following indirect or direct measures: Serum testosterone level Semen analysis 5.11 FOLLISTIM Pen The FOLLISTIM Pen is intended only for use with FOLLISTIM AQ Cartridge. (etykieta leku Folitropina, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

…medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (etykieta leku Glimepiryd, Interakcje z innymi lekami)

Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval. (etykieta leku Goserelina, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT. (etykieta leku Leuprorelina, Ostrzeżenia i środki ostrożności)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nictonic Acid These drugs may decrease serum TBG concentration. (etykieta leku Lewotyroksyna, Interakcje z innymi lekami)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration. (etykieta leku Liotyronina, Interakcje z innymi lekami)

Weak CYP3A4 Inhibitors Weak CYP3A4 inhibitors (such as alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, zileuton) can increase lomitapide exposure approximately 2-fold [see Clinical Pharmacology… (etykieta leku Lomitapid, Interakcje z innymi lekami)

However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. (etykieta leku Lowastatyna, Interakcje z innymi lekami)

The following laboratory tests may be affected by progestins including MPA Injectable Suspension, USP: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (etykieta leku Medroksyprogesteron, Interakcje z innymi lekami)

Clinical studies have shown that with co-administration of bicalutamide, mean midazolam (a CYP 3A4 substrate) levels may be increased 1.5-fold (for C max ) and 1.9-fold (for AUC). (etykieta leku Bikalutamid, Interakcje z innymi lekami)

…anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (etykieta leku Pioglitazon + glimepiryd, Interakcje z innymi lekami)

Reproductive effects: Include decreased testosterone and increased prolactin levels. (etykieta leku Ramelteon, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Abiraterone: Spironolactone binds to the androgen receptor and may increase prostate‑specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. (etykieta leku Spironolakton + hydrochlorotiazyd, Interakcje z innymi lekami)

Hypercalcemia in Patients with Metastatic Breast Cancer As with other additive hormonal therapy (estrogens and androgens), hypercalcemia has been reported in some breast cancer patients with bone metastases within a few weeks of starting treatment with tamoxifen. (etykieta leku Tamoksyfen, Ostrzeżenia i środki ostrożności)

Tumor Flare: Transient increase in serum testosterone levels can occur within the first few weeks of treatment. (etykieta leku Tryptorelina, Ostrzeżenia i środki ostrożności)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)