Interações de Bicalutamida
Bicalutamida (Casodex), androgênio, tem 35 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 3; moderadas: 32; leves: 0; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.
Interações segundo a bula
Interações graves (3)
These drugs include, but are not limited to, the following: the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin the androgen receptor inhibitor enzalutamide the antimycobacterials rifampin, rifapentine the cytotoxic agent mitotane St. (bula de Doravirina, Contraindicações)
Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant female who receives finasteride. (bula de Finasterida, Contraindicações)
CONTRAINDICATIONS: Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (bula de Gonadotrofina coriônica, Contraindicações)
Interações moderadas (32)
- AlfacoriogonadotropinaModerada
PRECAUTIONS General Induction of androgen secretion by hCG may cause fluid retention. (bula de Alfacoriogonadotropina, Precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Abiraterone: Spironolactone binds to the androgen receptor and may increase prostate‑specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. (bula de Espironolactona + hidroclorotiazida, Interações medicamentosas)
Free hormone concentrations, such as testosterone and estradiol, may be decreased. (bula de Estradiol + noretisterona, Advertências e precauções)
Free hormone concentrations, such as testosterone and estradiol, may be decreased. (bula de Estrogênios conjugados, Precauções)
Free hormone concentrations, such as testosterone and estradiol, may be decreased. (bula de Estrogênios conjugados + bazedoxifeno, Advertências e precauções)
Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (bula de Bicalutamida, Advertências e precauções)
Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (bula de Fludrocortisona, Interações medicamentosas)
- FolitropinaModerada
For Men : Clinical monitoring for spermatogenesis utilizes the following indirect or direct measures: Serum testosterone level Semen analysis 5.11 FOLLISTIM Pen The FOLLISTIM Pen is intended only for use with FOLLISTIM AQ Cartridge. (bula de Folitropina, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
…medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (bula de Glimepirida, Interações medicamentosas)
- GosserrelinaModerada
Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval. (bula de Gosserrelina, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
- LeuprorrelinaModerada
Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT. (bula de Leuprorrelina, Advertências e precauções)
Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nictonic Acid These drugs may decrease serum TBG concentration. (bula de Levotiroxina, Interações medicamentosas)
Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration. (bula de Liotironina, Interações medicamentosas)
- LomitapidaModerada
Weak CYP3A4 Inhibitors Weak CYP3A4 inhibitors (such as alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, zileuton) can increase lomitapide exposure approximately 2-fold [see Clinical Pharmacology… (bula de Lomitapida, Interações medicamentosas)
However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. (bula de Lovastatina, Interações medicamentosas)
The following laboratory tests may be affected by progestins including MPA Injectable Suspension, USP: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (bula de Medroxiprogesterona, Interações medicamentosas)
Clinical studies have shown that with co-administration of bicalutamide, mean midazolam (a CYP 3A4 substrate) levels may be increased 1.5-fold (for C max ) and 1.9-fold (for AUC). (bula de Bicalutamida, Interações medicamentosas)
…anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (bula de Pioglitazona + glimepirida, Interações medicamentosas)
Reproductive effects: Include decreased testosterone and increased prolactin levels. (bula de Ramelteona, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Hypercalcemia in Patients with Metastatic Breast Cancer As with other additive hormonal therapy (estrogens and androgens), hypercalcemia has been reported in some breast cancer patients with bone metastases within a few weeks of starting treatment with tamoxifen. (bula de Tamoxifeno, Advertências e precauções)
- TriptorrelinaModerada
Tumor Flare: Transient increase in serum testosterone levels can occur within the first few weeks of treatment. (bula de Triptorrelina, Advertências e precauções)
Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (bula de Bicalutamida, Advertências e precauções)
Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (bula de Bicalutamida, Advertências e precauções)
Verifique Bicalutamida com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.
Abrir no verificadorNão é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.