Wechselwirkungen von Bicalutamid

CONTRAINDICATIONS: Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (Fachinformation zu Choriongonadotropin, Gegenanzeigen)

These drugs include, but are not limited to, the following: the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin the androgen receptor inhibitor enzalutamide the antimycobacterials rifampin, rifapentine the cytotoxic agent mitotane St. (Fachinformation zu Doravirin, Gegenanzeigen)

Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant female who receives finasteride. (Fachinformation zu Finasterid, Gegenanzeigen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

PRECAUTIONS General Induction of androgen secretion by hCG may cause fluid retention. (Fachinformation zu Choriogonadotropin alfa, Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Fachinformation zu Estradiol und Norethisteron, Warnhinweise und Vorsichtsmaßnahmen)

Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (Fachinformation zu Fludrocortison, Arzneimittelwechselwirkungen)

For Men : Clinical monitoring for spermatogenesis utilizes the following indirect or direct measures: Serum testosterone level Semen analysis 5.11 FOLLISTIM Pen The FOLLISTIM Pen is intended only for use with FOLLISTIM AQ Cartridge. (Fachinformation zu Follitropin, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

…medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (Fachinformation zu Glimepirid, Arzneimittelwechselwirkungen)

Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval. (Fachinformation zu Goserelin, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Fachinformation zu Konjugierte Estrogene, Vorsichtsmaßnahmen)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Fachinformation zu Konjugierte Estrogene und Bazedoxifen, Warnhinweise und Vorsichtsmaßnahmen)

Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT. (Fachinformation zu Leuprorelin, Warnhinweise und Vorsichtsmaßnahmen)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nictonic Acid These drugs may decrease serum TBG concentration. (Fachinformation zu Levothyroxin, Arzneimittelwechselwirkungen)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration. (Fachinformation zu Liothyronin, Arzneimittelwechselwirkungen)

Weak CYP3A4 Inhibitors Weak CYP3A4 inhibitors (such as alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, zileuton) can increase lomitapide exposure approximately 2-fold [see Clinical Pharmacology… (Fachinformation zu Lomitapid, Arzneimittelwechselwirkungen)

However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. (Fachinformation zu Lovastatin, Arzneimittelwechselwirkungen)

The following laboratory tests may be affected by progestins including MPA Injectable Suspension, USP: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (Fachinformation zu Medroxyprogesteron, Arzneimittelwechselwirkungen)

Clinical studies have shown that with co-administration of bicalutamide, mean midazolam (a CYP 3A4 substrate) levels may be increased 1.5-fold (for C max ) and 1.9-fold (for AUC). (Fachinformation zu Bicalutamid, Arzneimittelwechselwirkungen)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

…anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (Fachinformation zu Pioglitazon und Glimepirid, Arzneimittelwechselwirkungen)

Reproductive effects: Include decreased testosterone and increased prolactin levels. (Fachinformation zu Ramelteon, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Abiraterone: Spironolactone binds to the androgen receptor and may increase prostate‑specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. (Fachinformation zu Spironolacton und Hydrochlorothiazid, Arzneimittelwechselwirkungen)

Hypercalcemia in Patients with Metastatic Breast Cancer As with other additive hormonal therapy (estrogens and androgens), hypercalcemia has been reported in some breast cancer patients with bone metastases within a few weeks of starting treatment with tamoxifen. (Fachinformation zu Tamoxifen, Warnhinweise und Vorsichtsmaßnahmen)

Tumor Flare: Transient increase in serum testosterone levels can occur within the first few weeks of treatment. (Fachinformation zu Triptorelin, Warnhinweise und Vorsichtsmaßnahmen)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (Fachinformation zu Bicalutamid, Warnhinweise und Vorsichtsmaßnahmen)