تداخلات بيكالوتاميد

These drugs include, but are not limited to, the following: the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin the androgen receptor inhibitor enzalutamide the antimycobacterials rifampin, rifapentine the cytotoxic agent mitotane St. (نشرة دورافيرين، موانع الاستعمال)

Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant female who receives finasteride. (نشرة فيناستيريد، موانع الاستعمال)

CONTRAINDICATIONS: Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (نشرة موجهة الغدد التناسلية المشيمائية، موانع الاستعمال)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (نشرة إستراديول ونوريثيستيرون، التحذيرات والاحتياطات)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (نشرة إستروجينات مقترنة، الاحتياطات)

Free hormone concentrations, such as testosterone and estradiol, may be decreased. (نشرة إستروجينات مقترنة وبازيدوكسيفين، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

…anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (نشرة بيوغليتازون وغليميبيريد، التداخلات الدوائية)

Hypercalcemia in Patients with Metastatic Breast Cancer As with other additive hormonal therapy (estrogens and androgens), hypercalcemia has been reported in some breast cancer patients with bone metastases within a few weeks of starting treatment with tamoxifen. (نشرة تاموكسيفين، التحذيرات والاحتياطات)

Tumor Flare: Transient increase in serum testosterone levels can occur within the first few weeks of treatment. (نشرة تريبتوريلين، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Reproductive effects: Include decreased testosterone and increased prolactin levels. (نشرة راميلتيون، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Abiraterone: Spironolactone binds to the androgen receptor and may increase prostate‑specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. (نشرة سبيرونولاكتون وهيدروكلوروثيازيد، التداخلات الدوائية)

…medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (نشرة غليميبيريد، التداخلات الدوائية)

Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval. (نشرة غوسيريلين، التحذيرات والاحتياطات)

Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. (نشرة فلودروكورتيزون، التداخلات الدوائية)

For Men : Clinical monitoring for spermatogenesis utilizes the following indirect or direct measures: Serum testosterone level Semen analysis 5.11 FOLLISTIM Pen The FOLLISTIM Pen is intended only for use with FOLLISTIM AQ Cartridge. (نشرة فوليتروبين، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

PRECAUTIONS General Induction of androgen secretion by hCG may cause fluid retention. (نشرة كوريوغونادوتروبين ألفا، الاحتياطات)

However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. (نشرة لوفاستاتين، التداخلات الدوائية)

Weak CYP3A4 Inhibitors Weak CYP3A4 inhibitors (such as alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, zileuton) can increase lomitapide exposure approximately 2-fold [see Clinical Pharmacology… (نشرة لوميتابيد، التداخلات الدوائية)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nictonic Acid These drugs may decrease serum TBG concentration. (نشرة ليفوثيروكسين، التداخلات الدوائية)

Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT. (نشرة ليوبروليد، التحذيرات والاحتياطات)

Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration. (نشرة ليوثيرونين، التداخلات الدوائية)

Clinical studies have shown that with co-administration of bicalutamide, mean midazolam (a CYP 3A4 substrate) levels may be increased 1.5-fold (for C max ) and 1.9-fold (for AUC). (نشرة بيكالوتاميد، التداخلات الدوائية)

The following laboratory tests may be affected by progestins including MPA Injectable Suspension, USP: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (نشرة ميدروكسي بروجستيرون، التداخلات الدوائية)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (نشرة بيكالوتاميد، التحذيرات والاحتياطات)